Chemical Hygiene

Chemical Safety

General Information

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Chemical Compatibility

Information Sources:

The EPA’s Chemical Compatibility Chart provides a summary table of EPA-600/2-80-076 April 1980 A METHOD FOR DETERMINING THE COMPATIBILITY OF CHEMICAL MIXTURES. The chart gives names of chemical classes with which the chosen class is incompatible. Legend indicates "Consequences" that can be expected when mixing chemical wastes.

Another good source for chemical compatibility predictions is Cameo Chemicals: Database of Hazardous Materials. Office of Response and Restoration, National Ocean Service, NOAA. (Accessed 08/04/2011).

This website provides:

  • Database of reactivity information for more than 5,000 chemicals and chemical mixtures. The database includes information about the special hazards of each chemical and about whether a chemical reacts with air, water, or other materials.
  • Permits virtual "mixing" of chemicals to find out what dangers could arise from accidental mixing.
  • Build a temporary list of chemicals and predict reactivity online.

EPA Chemical Compatibility Chart (PDF)



Topics include:  emergency procedures, OSHA Lab Safety Standard, health and physical hazards, routes of exposure, signs and symptoms of exposure, hazard identification, engineering controls, SOPs, PPE, waste management, housekeeping, audits

Laboratory Safety Training Outline

General Lab Safety/Chemical Hygiene

  1. OSHA Requirements
  2. Risk Assessments
  3. Hierarchy of Controls
  4. Hazard and Risk Assessments
  5. Hazard Prevention / Risk Mitigation
  6. Information and Training
  7. Emergency Procedures and Awareness
    1. Campus Phones 911; Cell Phones 937-775-2111
    2. Emergency Action Plan
    3. Emergency Audibles
    4. AED and Fire Extinguishers
    5. Chemical Spills
    6. Accidents and Spills
    7. PPE
    8. Eye Wash and Safety Shower
    9. Accident/Injury Reporting
  8. Lab Safety/OSHA 29CFR 1910.1450)
    1. Guiding Principles
    2. Chemical Hygiene Plan
      1. Basic Rules and Procedures
        1. Avoidance of Routine exposure
        2. Choice of Chemicals
        3. Eating, Drinking, Smoking, etc
        4. Equipment and Glassware
        5. Exiting the Lab
        6. Mouth Suction
        7. Horseplay
        8. Personal Protection
        9. Personal Apparel
        10. Respiratory Protection
        11. General Lab Practices
          1. Personal housekeeping
          2. Planning
          3. Unattended operations
          4. Use of hoods
          5. Working alone
      2. Chemical Procurement, Distribution, and Storage
        1. Segregate by hazard class
        2. Inventory
        3. Secondary Containers for transfer
        4. Storage Guidelines
      3. Environmental Monitoring
      4. Housekeeping, Maintenance and Inspections
      5. Medical Program
      6. Personal Protective Apparel and Equipment
      7. Records
      8. Signs and Labels
      9. Spills and Accidents
      10. Training and Information
      11. Waste Disposal
    3. Classifications of Chemical Laboratory Work
      1. Types of Chemicals
      2. Handling Requirements
      3. Locations
      4. Waste
      5. Access
      6. Approval
      7. Non-contamination or decontamination
      8. Exiting
      9. Medical Surveillance
    4. Particularly Hazardous Substances
      1. Includes:
        1. Select carcinogens
        2. Reproductive Toxins
        3. Acutely Toxic
      2. Provisions
        1. Designated area
        2. Containment devices
        3. Waste procedures
        4. Decontamination procedures
        5. SOP
  9. Special Hazards
    1. Gases under pressure
    2. Flammable materials
    3. Corrosive materials
    4. Reactive Materials
    5. Incompatible Materials
    6. Cryogenic Liquids