Chemistry Seminar: "Radical Chaperone-Mediated Directed C-H Functionalization"

David Nagib, Ph.D.,
Department of Chemistry & Biochemistry, The Ohio State University, Columbus, Ohio
"Radical Chaperone-Mediated Directed C-H Functionalization"

Abstract

Our research is focused on harnessing the untapped reactivity of cheap and abundant chemical feedstocks in organic synthesis to enable the late-stage functionalization of complex natural products and other medicinally-relevant molecules. We have recently developed an approach for the selective beta C-H functionalization of alcohols and amines, using a combination of radical (1e-) and closed shell (2e-) processes that act in concert with one another. This new radical chaperone strategy may offer the opportunity to selectively target and manipulate remote C-H bonds and promote a variety of unprecedented C-H functionalizations within molecules of biological and industrial interest.