The Multi-Scale Cardiovascular Bioengineering Laboratory (MSCBL) was established in August 2008. The lab is hosted by the Department of Mechanical and Materials Engineering at Wright State University (Dayton, OH).
The MSCBL aims at elucidating the complex relationships between cardiovascular tissue biology and hemodynamics at the gene, cell and tissue levels. The knowledge of such relations will guide the development of early medical interventions for the treatment of degenerative and congenital cardiovascular disorders.
The MSCBL applies state-of-the art engineering techniques to solve challenges in cardiovascular medicine. The research conducted in the MSCBL adopts an integrative approach to:
1- understand the complications caused by congenital and degenerative cardiovascular disorders
2- optimize the tissue engineering of functional heart valve substitutes
3- predict cardiovascular tissue remodeling and disease progression from a fluid mechanical perspective.
In this highly interactive research program, the knowledge of the flow characteristics in different cardiovascular disorder configurations and the identification and prediction of the mechanobiological pathways leading to those disorders will guide the development of early medical interventions for the treatment of cardiovascular pathologies.
Our research interests are in the engineering discipline of fluid mechanics, with application to the mechanobiology of cardiovascular structures. Mechanobiology is an emerging field of science, which describes how mechanical forces affect the biology of living systems. It has provided a new way to think about the function of cells, tissues and organs, and is now considered a potential tool to elucidate disease mechanisms. Mechanobiology requires a multidisciplinary approach in which the detailed description of the mechanical environment and the thorough analysis of its effects on tissue biology are addressed in tandem. Historically, such studies have put more emphasis on the biological description of mechano-sensitive processes in simplified biological models than on the implementation of realistic mechanical stimuli due to the limited knowledge of the native mechanical environment and the challenge to replicate it on intact tissue in the laboratory. The lack of realistic laboratory models that duplicate the native tissue mechanical environment has hampered our understanding of mechano-sensitive disease processes and the development of early diagnosis and therapeutic modalities. Therefore, our primary research interests are in the characterization of the native hemodynamics and the elucidation of the mechano-sensitive response in cardiovascular tissue and medical devices, with a particular focus on valvular disease.
Our current research focus is on:
• fluid-structure interactions in the aortic valve and their relationship to valvular calcification
• flow abnormalities in the bicuspid aortic valve and their impact on aortopathy
• left ventricular defects and their hemodynamic effects on discrete subaortic stenosis
• flow in hemodialysis vascular access and its role in vascular access failure
While these disorders have been studied for decades, the causality between hemodynamic abnormalities and pathogenesis has never been rigorously established. The MSCBL has invested in the development of new approaches addressing the fluid mechanical and biological aspects of those disorders at the same level of depth, and is one of the few with such expertise.
Research conducted in the MSCBL has been supported by:
1- the American Heart Association
2- the National Science Foundation
3- the National Institutes of Health
Danielle Massé and Jason Shar publish a paper titled "Discrete Subaortic Stenosis: Perspective Roadmap to a Complex Disease" in Frontiers in Cardiovascular Medicine
[Danielle Massé][Jason Shar]Publication
Janet Liu and Jason Shar publish a paper on "Wall Shear Stress Directional Abnormalities in BAV Aortas: Toward a New Hemodynamic Predictor of Aortopathy?" in Frontiers in Physiology
[Janet Liu][Jason Shar]Publication
The MSCBL is awarded $294,000 by the National Heart, Lung and Blood Institute for studying the hemodynamic mechanisms of discrete subaortic stenosis in a project led by collaborators at Rice University, Texas Children’s Hospital and Baylor College of Medicine
Ashish Madan receives his Masters degree in Mechanical Engineering for his thesis on "In vitro assessment of the effects of valvular stenosis on aorta hemodynamics and left ventricular function"
[Ashish Madan]MS Thesis
Janet Liu receives her Masters degree in Mechanical Engineering for her thesis on "A novel tissue culture system to subject aortic tissue to multidirectional bicuspid aortic valve wall shear stress"
[Janet Liu]MS Thesis
Samantha Atkins receives her Doctoral degree in Bioengineering for her dissertation work on "The hemodynamic theory of bicuspid aortic valve disease"
[Samantha Atkins]PhD Dissertation