Paliy Lab
Diggs Laboratory for Life Science Research : Department of Biochemistry and Molecular Biology : Wright State University
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Welcome to Paliy Lab web site


Dr. Paliy

Dr. Oleg Paliy, Ph.D.

Associate Professor

260 Diggs, Department of Biochemistry and Molecular Biology, 3640 Col. Glenn Hwy, Dayton, OH 45435

e-mail: e_mail_address

Education:

B.Sc.+M.Sc.: Lviv State University, Lviv, Ukraine. 1992-1997. Genetics and Genetic Engineering.

Ph.D.: University of Manchester, Manchester, UK. 1997-2001. Microbial Molecular and Structural Biology.

Postdoctoral: University of California at Berkeley, Berkeley, CA, USA. 2001-2004. Microbiology and Systems Biology.


Areas of research interests

 

Methodologies used

  • Role of gut microbes in human health and in gastrointestinal diseases such as IBS, colon cancer, and obesity

  • Metabolic interactions in complex microbial communities

  • Host-microbial interactions and stress responses of pathogenic and commensal Enterobacteria

  • Use of metabolic and mathematical modeling to study biological principles

 
  • Standard microbiology techniques

  • Standard molecular biology methods

  • Gene expression profiling with microarrays and qPCR

  • Microbial community analysis by high-throughput sequencing, phylogenetic microarrays, and FISH

  • Bioinformatics and computational biology

  • Biostatistics and phylogenetic analysis


Next-generation sequencing facility: click here for details


Recent news


  • Student recognized:

    Vijay Shankar, a talented PhD student in the lab, has won the Best Graduate Student Poster Presentation Award at the OBASM 2014 meeting.

  • Paper published:

    V. Shankar, M.J. Hamilton, A. Khoruts, A. Kilburn, T. Unno, O. Paliy, and M.J. Sadowsky. Species and genus level resolution analysis of gut microbiota in Clostridium difficile patients following fecal microbiota transplantation (2014) Microbiome, 2:13.

  • Student recognized:

    Richard Agans, a productive PhD student in the lab, was nominated for Biomedical Sciences PhD program Graduate Student Excellence Award.

  • Paper published:

    V. Shankar, R. Agans, B. Holmes, M. Raymer, and O. Paliy. Do gut microbial communities differ in pediatric IBS and health? (2013) Gut Microbes, 4(4): 347–352.

  • Paper published:

    B. Withman, T.S. Gunasekera, P. Beesetty, R. Agans, and O. Paliy. Transcriptional responses of uropathogenic Escherichia coli to increased environmental osmolality caused by salt or urea (2013) Infect. Immun., 81(1): 80-89.

  • Student grant award:

    Christina Roth, a talented undergraduate student in the lab, has received an Undergraduate Research Grant award from WSU for Fall semester of 2012.

  • Paper published:

    L. Rigsbee, R. Agans, V. Shankar, H. Kenche, H. Khamis, S. Michail, and O. Paliy. Quantitative profiling of gut microbiota of children with diarrhea-predominant irritable bowel syndrome (2012) Am. J. Gastroenterol., 107: 1740-51.

  • Student grant awards:

    Richard Agans and Vijay Shankar, two PhD students in the lab, have both received an Original Work Grant from WSU Graduate Student Assembly for 2012 year.

  • Paper published:

    O. Paliy and R. Agans. Application of phylogenetic microarrays to interrogation of human microbiota (2012) FEMS Microbiol. Ecol., 79(1):2-11.

  • Paper published:

    O. Paliy and B. Foy. Mathematical modeling of 16S ribosomal DNA amplification reveals optimal conditions for the interrogation of complex microbial communities with phylogenetic microarrays (2011) Bioinformatics, 27(15): 2134-40.

  • Paper published:

    R. Agans, L. Rigsbee, H. Kenche, S. Michail, H.J. Khamis, and O. Paliy. Distal gut microbiota of adolescent children is different from that of adults (2011) FEMS Microbiol. Ecol., 77(2): 404-12.

  • Student presents poster:

    V. Shankar, L. Rigsbee, H. Kenche, S. Michail, and O. Paliy Effects of VSL#3 on the composition of intestinal microbiota in IBS-D patients. FASEB Probiotics, Intestinal Microbiota and the Host, Carefree, AZ, 2011

  • Paper published:

    L. Rigsbee, R. Agans, B. Foy, and O. Paliy. Optimizing the analysis of human intestinal microbiota with phylogenetic microarray (2011) FEMS Microbiol. Ecol., 75:332-42.

  • Student grant award:

    Rebekah Bogard, an undergraduate student in the lab, has received an Undergraduate Research Support Grant award from WSU for 2011 year.


Current and past funding


  • NSF Major Research Instrumentation Grant [2013-2015] "Establishment of next-generation sequencing facility at WSU"

  • WSU BSoM Emerging Science Program [2013-2014] "Gut microbiota in children of developing world"

  • Procter & Gamble Research Grant [2011-2016] "Studies of human gut microbiota"

  • WSU BSoM Research Challenge [2011-2012] "High-throughput detection of quantitative differences in intestinal microbiota in patients with colorectal cancer and advanced adenomatous polyps"

  • NIH NICHD [2010-2013] "Quantitative measurements of intestinal metabolites in healthy and IBS children"

  • Procter & Gamble Research Grant [2010-2011] "DNA extraction from fecal material"

  • NIH NCCAM [2008-2011] "Using Affymetrix Microflora array to study microflora composition in children with IBS"

  • WSU SoM Research Challenge [2007-2008] "Design and implementation of custom GeneChip community microarray to study human microflora"

 
 
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Saturday, 30-Aug-2014 16:39:54 EDT
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