Paliy Lab
Diggs Laboratory for Life Science Research : Department of Biochemistry and Molecular Biology : Wright State University
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Welcome to Paliy Lab web site


Dr. Paliy

Dr. Oleg Paliy, Ph.D.

Associate Professor

260 Diggs, Department of Biochemistry and Molecular Biology, 3640 Col. Glenn Hwy, Dayton, OH 45435

e-mail: e_mail_address

Education:

B.Sc.+M.Sc.: Lviv State University, Lviv, Ukraine. 1992-1997. Microbial Genetics and Genetic Engineering.

Ph.D.: University of Manchester, Manchester, UK. 1997-2001. Microbial Molecular and Structural Biology.

Postdoctoral: University of California at Berkeley, Berkeley, CA, USA. 2001-2004. Microbial Systems Biology.


Areas of research interests

 

Methodologies used

  • Role of gut microbes in human health and in gastrointestinal diseases such as IBS, diabetes, and obesity

  • Metabolic interactions in complex microbial communities

  • Host-microbial interactions of pathogenic and commensal enterobacteria

  • Use of metabolic and mathematical modeling to study biological principles

 
  • Standard microbiology techniques

  • Standard molecular biology methods

  • Gene expression profiling with microarrays and qPCR

  • Microbial community analysis by high-throughput sequencing, phylogenetic microarrays, and FISH

  • Bioinformatics and computational biology

  • Biostatistics and phylogenetic analysis


Next-generation sequencing facility: click here for details


Recent news


  • Paper published:

    V. Shankar, N.V. Reo, and O. Paliy. Simultaneous fecal microbial and metabolite profiling enables accurate classification of pediatric irritable bowel syndrome (2015) Microbiome, 3:73.

  • Students present posters:

    R. Agans, L. Rigsbee, O. Paliy. Human gut microbiota is efficient in utilizing dietary fats for growth as revealed by long-term community maintenance in the in vitro gut simulator. Microbiome Symposium, Ann Arbor, MI, 2015.

    V. Shankar, D. Homer, L. Rigsbee, M. Raymer, N. V. Reo, O. Paliy. Simultaneous interrogation of fecal metabolites and microbes reveals differences in the network of gut microbe-metabolite associations between health and irritable bowel syndrome. Microbiome Symposium, Ann Arbor, MI, 2015.

  • Student receives fellowship award:

    Richard Agans and Dr. Oleg Paliy have been awarded the DAGSI/AFRL Ohio Student-Faculty Fellowship award. The title of the project is "Biomolecular interaction of nanoparticles and other aerospace chemicals with gut microbial and metabolite profiles".

  • Student grant award:

    Alex Gordon, a talented graduate student in the lab, has received an Original Work Grant from WSU Graduate Student Assembly for 2015 year.

  • Paper published:

    V. Shankar, D. Homer, L. Rigsbee, H.J. Khamis, S. Michail, M. Raymer, N.V. Reo, and O. Paliy. The networks of human gut microbe-metabolite associations are different between health and irritable bowel syndrome (2015) ISME J, 9(8): 1899-903.

  • Student presents poster:

    V. Shankar, D. Homer, L. Rigsbee, H. J. Khamis, M. Raymer, N. V. Reo, O. Paliy. Simultaneous interrogation of fecal metabolites and microbes reveals differences in the network of gut microbe-metabolite associations between health and irritable bowel syndrome. ASM Beneficial Microbes 5 International Conference, Washington, DC, 2014.

  • Student recognized:

    Vijay Shankar, a talented PhD student in the lab, has won the Best Graduate Student Poster Presentation Award at the OBASM 2014 meeting.

  • Paper published:

    V. Shankar, M.J. Hamilton, A. Khoruts, A. Kilburn, T. Unno, O. Paliy, and M.J. Sadowsky. Species and genus level resolution analysis of gut microbiota in Clostridium difficile patients following fecal microbiota transplantation (2014) Microbiome, 2:13.

  • Student recognized:

    Richard Agans, a productive PhD student in the lab, was nominated for Biomedical Sciences PhD program Graduate Student Excellence Award in 2013.

  • Paper published:

    V. Shankar, R. Agans, B. Holmes, M. Raymer, and O. Paliy. Do gut microbial communities differ in pediatric IBS and health? (2013) Gut Microbes, 4(4): 347–352.

  • Paper published:

    B. Withman, T.S. Gunasekera, P. Beesetty, R. Agans, and O. Paliy. Transcriptional responses of uropathogenic Escherichia coli to increased environmental osmolality caused by salt or urea (2013) Infect. Immun., 81(1): 80-89.

  • Student grant award:

    Christina Roth, a talented undergraduate student in the lab, has received an Undergraduate Research Grant award from WSU for Fall semester of 2012.

  • Paper published:

    L. Rigsbee, R. Agans, V. Shankar, H. Kenche, H. Khamis, S. Michail, and O. Paliy. Quantitative profiling of gut microbiota of children with diarrhea-predominant irritable bowel syndrome (2012) Am. J. Gastroenterol., 107: 1740-51.

  • Student grant awards:

    Richard Agans and Vijay Shankar, two PhD students in the lab, have both received an Original Work Grant from WSU Graduate Student Assembly for 2012 year.

  • Paper published:

    O. Paliy and R. Agans. Application of phylogenetic microarrays to interrogation of human microbiota (2012) FEMS Microbiol. Ecol., 79(1):2-11.

  • Paper published:

    O. Paliy and B. Foy. Mathematical modeling of 16S ribosomal DNA amplification reveals optimal conditions for the interrogation of complex microbial communities with phylogenetic microarrays (2011) Bioinformatics, 27(15): 2134-40.

  • Paper published:

    R. Agans, L. Rigsbee, H. Kenche, S. Michail, H.J. Khamis, and O. Paliy. Distal gut microbiota of adolescent children is different from that of adults (2011) FEMS Microbiol. Ecol., 77(2): 404-12.


Current and past funding


  • NIH NIDDK R01 [2015-2020] "Intestinal epithelial cell regulation of allergic inflammation at distant sites"

  • DAGSI / Air Force Research Laboratory [2015-2016] "Biomolecular interaction of nanoparticles and other aerospace chemicals with gut microbial and metabolite profiles"

  • NSF Major Research Instrumentation Grant [2013-2016] "Establishment of next-generation sequencing facility at WSU"

  • WSU BSoM Emerging Science Program [2013-2014] "Gut microbiota in children of developing world"

  • Procter & Gamble Research Grant [2011-2016] "Studies of human gut microbiota"

  • WSU BSoM Research Challenge [2011-2012] "High-throughput detection of quantitative differences in intestinal microbiota in patients with colorectal cancer and advanced adenomatous polyps"

  • NIH NICHD [2010-2013] "Quantitative measurements of intestinal metabolites in healthy and IBS children"

  • Procter & Gamble Research Grant [2010-2011] "DNA extraction from fecal material"

  • NIH NCCAM [2008-2011] "Using Affymetrix Microflora array to study microflora composition in children with IBS"

  • WSU SoM Research Challenge [2007-2008] "Design and implementation of custom GeneChip community microarray to study human microflora"

 
 
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