Dr. Oleg Paliy, Ph.D.

Associate Professor

260 Diggs, Department of Biochemistry and Molecular Biology, 3640 Col. Glenn Hwy, Dayton, OH 45435

e-mail:

Education:

B.Sc.+M.Sc.: Lviv State University, Lviv, Ukraine. 1992-1997. Genetics and Genetic Engineering.

Ph.D.: University of Manchester, Manchester, UK. 1997-2001. Microbial Molecular and Structural Biology.

Postdoctoral: University of California at Berkeley, Berkeley, CA, USA. 2001-2004. Microbiology and Systems Biology.

• Role of intestinal bacteria in human health and in gastrointestinal diseases such as IBS, colon cancer, and obesity

• Metabolic interactions in complex microbial communities

• Host-microbial interactions and stress responses of pathogenic and commensal Enterobacteria

• Use of genetic engineering and mathematical modeling to study biological principles

• Standard microbiology techniques

• Standard molecular biology methods

• Gene expression profiling with microarrays and qPCR

• Microbial community analysis by 16S RNA sequencing, phylogenetic microarrays, FISH, and in vitro systems

• Bioinformatics and computational biology

• Biostatistics and phylogenetic analysis
  

• Paper published:

  B. Withman, T.S. Gunasekera, P. Beesetty, R. Agans, and O. Paliy. Transcriptional responses of uropathogenic Escherichia coli to increased environmental osmolality caused by salt or urea (2013) Infect. Immun., 81(1): 80-89.

• Student grant award:

  Christina Roth, a talented undergraduate student in the lab, has received an Undergraduate Research Grant award from WSU for Fall semester of 2012.

• Paper published:

  L. Rigsbee, R. Agans, V. Shankar, H. Kenche, H. Khamis, S. Michail, and O. Paliy. Quantitative profiling of gut microbiota of children with diarrhea-predominant irritable bowel syndrome (2012) Am. J. Gastroenterol., 107: 1740-51.

• Student grant awards:

  Richard Agans and Vijay Shankar, PhD students in the lab, have both received an Original Work Grant from WSU Graduate Student Assembly for 2012 year.

• Paper published:

  O. Paliy and R. Agans. Application of phylogenetic microarrays to interrogation of human microbiota (2012) FEMS Microbiol. Ecol., 79(1):2-11.

• Paper published:

  O. Paliy and B. Foy. Mathematical modeling of 16S ribosomal DNA amplification reveals optimal conditions for the interrogation of complex microbial communities with phylogenetic microarrays (2011) Bioinformatics, 27(15): 2134-40.

• Paper published:

  R. Agans, L. Rigsbee, H. Kenche, S. Michail, H.J. Khamis, and O. Paliy. Distal gut microbiota of adolescent children is different from that of adults (2011) FEMS Microbiol. Ecol., 77(2): 404-12.

• Student presents poster:

  V. Shankar, L. Rigsbee, H. Kenche, S. Michail, and O. Paliy Effects of VSL#3 on the composition of intestinal microbiota in IBS-D patients. FASEB Probiotics, Intestinal Microbiota and the Host, Carefree, AZ, 2011

• Paper published:

  L. Rigsbee, R. Agans, B. Foy, and O. Paliy. Optimizing the analysis of human intestinal microbiota with phylogenetic microarray (2011) FEMS Microbiol. Ecol., 75:332-42.

• Student grant award:

  Rebekah Bogard, an undergraduate student in the lab, has received an Undergraduate Research Support Grant award from WSU for 2011 year.

• Students present posters:

  L. Rigsbee, R. Agans, B. Foy, and O. Paliy. Optimizing the detection of human intestinal microbiota with phylogenetic microarray. 3rd ASM Conference on Beneficial Microbes, Miami, FL, 2010

  R. Agans, H. Kenche, S. Michail, and O.Paliy. Fecal microbiota of adolescent children is different from that of adults. 3rd ASM Conference on Beneficial Microbes, Miami, FL, 2010

• Student award:

  Laura Rigsbee, a masters student in the lab, has received a Wright State University Graduate Student Excellence Award for the 2009/10 academic year.

• Procter & Gamble Research Grant [2011-2015] "Studies of human gut microbiota"

• WSU BSoM Research Challenge [2011-2012] "High-throughput detection of quantitative differences in intestinal microbiota in patients with colorectal cancer and advanced adenomatous polyps"

• NIH NICHD [2010-2013] "Quantitative measurements of intestinal metabolites in healthy and IBS children"

• Procter & Gamble Research Grant [2010-2011] "DNA extraction from fecal material"

• NIH NCCAM [2008-2011] "Using Affymetrix Microflora array to study microflora composition in children with IBS"

• WSU SoM Research Challenge [2007-2008] "Design and implementation of custom GeneChip community microarray to study human microflora"