Department of Neuroscience, Cell Biology, and Physiology

Research Interests

 

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Current Research Projects

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Mutation and Recombination of HIV-1
HIV-1 variation and its impact on the pathogenesis of AIDS is an ongoing area of investigation for me. Specifically, I study the molecular mechanisms by which HIV-1 mutates and recombines its genome. Genetic variation of HIV-1 is the single largest obstacle in developing effective vaccines and therapies for preventing AIDS.

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HIV-1 Infection of Eosinophils
I explore the susceptibility of eosinophils to HIV-1 infection, the interaction of HIV-1 with eosinophils, and the pathogenic effects that result from such infection or interaction. The eosinophil is a specific type of white blood cell crucial to the immune response against parasitic infections, especially helminthes.

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Gene Therapy for HIV-1
In collaboration with Dr. Kate Excoffon and Dr. David Schaffer, I am developing a targeted gene therapy approach against HIV-1 infection using novel Adeno-associated virus vectors.
Attempts to control the spread of HIV-1 have provided few successes in the past, and HIV-1 has demonstrated an unyielding ability to persist in the bodies of infected individuals. New strategies are urgently needed.

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Viral Vector Biosafety
In collaboration with Dr. Adrian Corbett, I am examining the safety of viral vectors in animal model systems with regard to environmental and laboratory worker protection.

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Nanotechnology
My laboratory was the first to show that antiviral effects of silver nanoparticles may be due to the inhibition of a cellular process involved in viral entry (see Trefry and Wooley, 2013). My research focuses on learning more about this mechanism and seeking ways to exploit this technology toward developing an antiviral therapy.

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Graduate Programs: Biomedical Sciences | Anatomy | Physiology & Neuroscience | Microbiology & Immunology

Department of Neuroscience, Cell Biology, and Physiology

143 Biological Sciences II Building
Wright State University
3640 Colonel Glenn Hwy.
Dayton, OH 45435 USA
Tel: (937) 775-3067
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Last Updated on 08/26/2014

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