Wright State University home page. From Invention to Market 2003: Celebrating the 
Commercial Power of Innovation



Dr. Thomas Brown with Kaisa Selesniemi and Hiloni Bhavsar
"Beta II Spectrin as a Diagnostic Indicator of Sjögren's syndrome"(PCT patent pending)
Sjögren's Syndrome is a debilitating autoimmune condition sometimes associated with other autoimmune conditions such as rheumatoid arthritis. The syndrome is characterized by the degeneration and salivary and lachrymal glands with secondary impact on the general physiology esp. the digestive system. The serum of patients affected with Sjögren Syndrome contains an autoantibody directed against a region of the Beta II Spectrin protein. Thus, the detection of Beta Spectrin autoantibodies should provide a useful early indicator of the disease.

Dr. Dan Krane with Jason Gilder, Carrie Rowland, Mike Raymer, and Travis Doom
"Objective Computer-assisted review of DNA evidence: the Genophiler DNA analysis software" Forensic Bioinformatics, Inc.
The Genophiler DNA Analysis software uses state of the art bioinformatics technology to rapidly and accurately profile DNA evidence used in criminal proceedings. With a significantly higher sensitivity than currently used laboratory DNA tests, Genophiler provides unbiased scientific analysis of DNA profiles.

Dr. Jay Dean with Alfredo J. Garcia III
"Optical Imaging Equipment for pressure Vessels"
Hyperbaric conditions encountered in diving, submarine, or subterranean environments present many physiologic challenges esp. to the respiratory and nervous systems. This DoD and Office of Naval Research funded research project aims to investigate the cellular effects of hyperbaric environment at the CNS and respiratory levels for those applications. In addition, pressure is also used to study the effects of intracranial pressure resulting from head injury as well as those of anesthetics on the CNS.

Our laboratory has developed two sophisticated pieces of equipment to support these studies:

  1. Fluorescence/video microscope that can be used under pressure conditions up to 5 Atmospheres absolute pressure (5 ATA)
  2. Optical pressure chamber to be used with a confocal microscope, to be used under pressure conditions up to 10 ATA.

Dr S. Berberich with Madhavi Kadakia, Ph.D. and Tina Caserta, M.S.
Gene Expression Laboratory: DNA microarray facility for performing gene expression profiling experiments and genotyping assays
The laboratory uses the AFFYMETRIX GeneChipsTM micorarray chips to examine in a very fast and accurate manner expression changes affecting a large number of genes.

Drs Fyffe, Milhorn with Irwin Simon
Genome Research Infrastructure Partnership
The GRIP is a consortium of academic, commercial and governmental research institutions dedicated to providing a platform of high-throughput technologies to support genome research and enhance Ohio's biotechnology industry.

Dr. Fyffe with Kathleen Friedman and Mark Willis
SoM Office of Research Affairs Center for Brain research
The office of Research Affairs provides strategic planning and research management for Wright State University and throughout the Miami Valley region.

The Center for Brain Research promotes interdisciplinary research collaboration focused brain function under healthy or pathological conditions. The CBR provides state of the art technology, technical staff and laboratories to address the numerous aspects of brain research.

Dr. Bourbakis with Ming Yang and Yuksel Akinci
Information Security: SCAN compression-encryption hiding
To address the growing need for increased digital information security as well as large volumes of electronic data transmission, ITRI has developed SCAN, a language that compresses data, hides digital information in images, and encrypts such images. Such method is of crucial interest for the protection of sensitive information that is stored or transits electronically.

Dr. Gallagher with Gregory Kramer, Saranyan Vigraham and Steve Peretta
Neuromorphic evolvable hardware for control and sensing
Evolvable Hardware (EH) uses simulated natural evolution to optimize machine design especially in situations where machines need to automatically self-repair without human intervention.

Dr. Quek with C. Kirbas
Wave Propagation and Traceback Approach of Automated Blood Vascular Extraction
This direct method enables the fine extraction of the neurovascular structure from a variety of medical images.

Dr. Narayanan with Seshu Edala, Lavanya Koppaka, Subhashini Ganapathy, Mike Findler and Rakesh Dave
Interactive Systems Modeling and Simulation
Laboratory The design of interactive systems to aid human in cognitively complex tasks has commercially appealing applications especially for situations requiring zero default. The laboratory uses a model-based approach to design such interactive systems:

  1. Model for supply chain application (Coll. Intel Corp)
  2. Model for source recommendation system in information retrieval (coll. Lexis Nexis)
  3. Computational architecture for supervisory control of remotely operated vehicles performing search and rescue missions (DAGSI/AFRL)

Dr. Hangartner with Julie A. Skipper

  1. Mass Screening Method for Osteoporosis (patent pending)
  2. Analysis of width and density of fine structures by computed tomography (US patents)
  3. Phantom and Method for Quality Assurance and Control of Bone absorptiometry
  1. This method uses a dental radiograph concurrently exposed with calibration wedge followed by film digitization and evaluation using a specific computer software.
  2. This method uses specifically designed phantoms to increase the measurement accuracy of size and density especially at resolution limit of the scanning system, which results in significantly lower blurring.
  3. A special phantom has been developed and tested for daily measurement with dual-energy absorptiometry scanners. These scanners are used for the assessment of bone density. Early detection of possible malfunctioning is of utmost importance to avoid misdiagnosis of patients. In case a shift in measured values due to replacement of a vital component, the phantom values provide an excellent basis for retrospective correction of patient evaluations, thus considerably improving the consistency of long-term studies.

Dr. Wayne Carmichael
Environmental testing methodologies
Harmful algal blooms (HABs) are found in the waters of almost every U.S. coastal state and in freshwater supplies of every U.S. state. The problem is recognized by almost all federal, state, local environmental and health agencies. Our technology showcase will demonstrate: 1) development and market technologies for rapid detection and identification of harmful algae and their biotoxins present in recreational, agricultural and municipal drinking water supplies. 2) development and marketing applications of these technologies for the management and mitigation of harmful algae blooms.

Dr. Burton
In situ-based technologies for US EPA programmatic needs
In situ based technologies provide accurate characterization of real world conditions in a quasi real time manner.

Dr. R. Siferd with Saiyu Ren, Mike Myers and Mingzhen Wang
"Broadband High Resolution Analog to Digital Converters"
The increased use of digital signal processing requires the use of broadband/high resolution Analog to Digital Converters (ADCs)

Dr. Goshtasby with Lyobomir Zagorchev and Dr. Martin Satter

  1. Multimodality Brain Image Registration
  2. High Dynamic Range Reduction in Images
  3. Geometric Modeling Using Control-Line Curves and Control-Plane Surfaces
  1. Multimodality Brain Image Registration is a computational method whereby highly heterogeneous brain images such as those obtained from MR, CT or PET can be combined and fused for quasi simultaneous analysis.
  2. This computational method enables the blending of multiple exposure images into a single image with maximum information content, resulting in a high quality image. This technology has commercial potential in the digital photography industry.
  3. This method allows to create complex geometric models with higher precision and in a shorter amount of time than possible through traditional control point modelization. This technology could be of interest for the creation of geometric models or particular industrial parts

Dr. Ramana Grandhi with Belur Badrinarayan, Nagarajan Thiyagarajan and Jalaja Repalle
"Distortion control in metal forming and cooling"
Dr. Grandhi and his team are developing a method based on the integration of computer simulation and experimental measurements to dramatically increase the quality of designs, processes and inspections of automotive and aerospace components. The use of such method could significantly increase manufacturing cost-effectiveness of such components.

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