Dr. Thomas Brown with Kaisa Selesniemi and Hiloni Bhavsar
"Beta II Spectrin as a Diagnostic Indicator of Sjögren's syndrome"(PCT patent pending)
Sjögren's Syndrome is a debilitating autoimmune condition sometimes associated with other autoimmune
conditions such as rheumatoid arthritis. The syndrome is characterized by the degeneration and salivary
and lachrymal glands with secondary impact on the general physiology esp. the digestive system.
The serum of patients affected with Sjögren Syndrome contains an autoantibody directed against a region of
the Beta II Spectrin protein. Thus, the detection of Beta Spectrin autoantibodies should provide a useful
early indicator of the disease.
Dr. Dan Krane with Jason Gilder, Carrie Rowland,
Mike Raymer, and
"Objective Computer-assisted review of DNA evidence: the Genophiler DNA analysis software"
Forensic Bioinformatics, Inc.
The Genophiler DNA Analysis software uses state of the art bioinformatics
technology to rapidly and accurately profile DNA evidence used in criminal proceedings. With a significantly
higher sensitivity than currently used laboratory DNA tests, Genophiler provides unbiased scientific analysis
of DNA profiles.
Dr. Jay Dean with Alfredo J. Garcia III
"Optical Imaging Equipment for pressure Vessels"
Hyperbaric conditions encountered in diving, submarine, or subterranean environments present many
physiologic challenges esp. to the respiratory and nervous systems. This DoD and Office of Naval
Research funded research project aims to investigate the cellular effects of hyperbaric environment at
the CNS and respiratory levels for those applications. In addition, pressure is also used to study the
effects of intracranial pressure resulting from head injury as well as those of anesthetics on the CNS.
Our laboratory has developed two sophisticated pieces of equipment to support these studies:
- Fluorescence/video microscope that can be used under pressure conditions up to 5 Atmospheres
absolute pressure (5 ATA)
- Optical pressure chamber to be used with a confocal microscope, to be used under pressure
conditions up to
Dr S. Berberich with Madhavi Kadakia, Ph.D. and Tina Caserta, M.S.
Gene Expression Laboratory: DNA microarray facility for performing gene expression profiling experiments
and genotyping assays
The laboratory uses the AFFYMETRIX GeneChipsTM micorarray chips to examine in a very
fast and accurate manner expression changes affecting a large number of genes.
Drs Fyffe, Milhorn with Irwin Simon
Genome Research Infrastructure Partnership
The GRIP is a consortium of academic, commercial and governmental research institutions dedicated to
providing a platform of high-throughput technologies to support genome research and enhance Ohio's
Dr. Fyffe with Kathleen Friedman and Mark Willis
SoM Office of Research Affairs Center for Brain research
The office of Research Affairs provides strategic planning and research management for Wright State
University and throughout the Miami Valley region.
The Center for Brain Research promotes interdisciplinary research collaboration focused brain function under
healthy or pathological conditions. The CBR provides state of the art technology, technical staff and
laboratories to address the numerous aspects of brain research.
Dr. Bourbakis with Ming Yang and Yuksel Akinci
Information Security: SCAN compression-encryption hiding
To address the growing need for increased digital information security as well as large volumes of electronic
data transmission, ITRI has developed SCAN, a language that compresses data, hides digital information
in images, and encrypts such images. Such method is of crucial interest for the protection of sensitive
information that is stored or transits electronically.
Dr. Gallagher with Gregory Kramer, Saranyan Vigraham and Steve Peretta
Neuromorphic evolvable hardware for control and sensing
Evolvable Hardware (EH) uses simulated natural evolution to optimize machine design especially in
situations where machines need to automatically self-repair without human intervention.
Dr. Quek with C. Kirbas
Wave Propagation and Traceback Approach of Automated Blood Vascular Extraction
This direct method enables the fine extraction of the neurovascular structure from a variety of
Dr. Narayanan with Seshu Edala, Lavanya Koppaka, Subhashini Ganapathy, Mike Findler and Rakesh Dave
Interactive Systems Modeling and Simulation
Laboratory The design of interactive systems to aid human in cognitively complex tasks has commercially
appealing applications especially for situations requiring zero default. The laboratory uses a model-based
approach to design such interactive systems:
- Model for supply chain application (Coll. Intel Corp)
- Model for source recommendation system in information retrieval (coll. Lexis Nexis)
- Computational architecture for supervisory control of remotely operated vehicles performing
search and rescue missions (DAGSI/AFRL)
Dr. Hangartner with Julie A. Skipper
- Mass Screening Method for Osteoporosis
- Analysis of width and density of fine structures by computed tomography
- Phantom and Method for Quality Assurance and Control of Bone absorptiometry
- This method uses a dental radiograph concurrently exposed with calibration wedge followed by film
digitization and evaluation using a specific computer software.
- This method uses specifically designed phantoms to increase the measurement accuracy of size and
especially at resolution limit of the scanning system, which results in significantly lower blurring.
- A special phantom has been developed and tested for daily measurement with dual-energy absorptiometry
scanners. These scanners are used for the assessment of bone density. Early detection of possible
malfunctioning is of utmost importance to avoid misdiagnosis of patients. In case a shift in measured
values due to replacement of a vital component, the phantom values provide an excellent basis for
retrospective correction of patient evaluations, thus considerably improving the consistency of
Dr. Wayne Carmichael
Environmental testing methodologies
Harmful algal blooms (HABs) are found in the waters of almost every U.S. coastal state and in freshwater
supplies of every U.S. state. The problem is recognized by almost all federal, state, local environmental
and health agencies. Our technology showcase will demonstrate: 1) development and market technologies for
rapid detection and identification of harmful algae and their biotoxins present in recreational, agricultural
and municipal drinking water supplies. 2) development and marketing applications of these technologies for
the management and mitigation of harmful algae blooms.
In situ-based technologies for US EPA programmatic needs
In situ based technologies provide accurate characterization of real world conditions in a quasi
real time manner.
Dr. R. Siferd with Saiyu Ren, Mike Myers and Mingzhen Wang
"Broadband High Resolution Analog to Digital Converters"
The increased use of digital signal processing requires the use of broadband/high resolution Analog
to Digital Converters (ADCs)
Dr. Goshtasby with Lyobomir Zagorchev and Dr. Martin Satter
- Multimodality Brain Image Registration
- High Dynamic Range Reduction in Images
- Geometric Modeling Using Control-Line Curves and Control-Plane Surfaces
- Multimodality Brain Image Registration is a computational method whereby highly heterogeneous
brain images such as those obtained from MR, CT or PET can be combined and fused for quasi simultaneous
- This computational method enables the blending of multiple exposure images into a single image
with maximum information content, resulting in a high quality image. This technology has commercial
potential in the digital photography industry.
- This method allows to create complex geometric models with higher precision and in a shorter
amount of time than possible through traditional control point modelization. This technology could be
of interest for the creation of geometric models or particular industrial parts
Dr. Ramana Grandhi with Belur Badrinarayan, Nagarajan Thiyagarajan and Jalaja Repalle
"Distortion control in metal forming and cooling"
Dr. Grandhi and his team are developing a method based on the integration of computer simulation and
experimental measurements to dramatically increase the quality of designs, processes and inspections
of automotive and aerospace components. The use of such method could significantly increase
manufacturing cost-effectiveness of such components.