Department of: Neuroscience, Cell Biology & Physiology

 

Chair: Timothy Cope

 

Phone: 937-775-3067

 

Email: ncbp@wright.edu

 


1.  Refereed publications and book chapters

 

Dr. Alvarez

 

Mentis, G. Z., Siembab, V. C., Zerda, R., O'Donovan, M. J., & Alvarez, F. J. (2006). Primary afferent synapses on developing and adult renshaw cells. J. Neurosci., 26(51), 13297-13310.

Dr. Brown

 

Gultice, A. D., Selesniemi, K. L., & Brown, T. L. (2006). Hypoxia inhibits differentiation of lineage-specific rcho-1 trophoblast giant cells. Biol. Reprod., 74(6), 1041-1050.

 

Kulkarni, K., Selesniemi, K., & Brown, T. L. (2006). Interferon-gamma sensitizes the human salivary gland cell line, hsg, to tumor necrosis factor-alpha induced activation of dual apoptotic pathways. Apoptosis, 11(12), 2205-2215.

 

Lauf, P. K., Warwar, R., Brown, T. L., & Adragna, N. C. (2006). Regulation of potassium transport in human lens epithelial cells. Exp. Eye Res., 82(1), 55-64.

 

Misri, S., Chimote, A. A., Adragna, N. C., Warwar, R., Brown, T. L., & Lauf, P. K. (2006). Kcc isoforms in a human lens epithelial cell line (b3) and lens tissue extracts. Exp. Eye Res., 83(5), 1287-1294.

Dr. Corbett

 

Jarnot, M., & Corbett, A. M. (2006). Immunolocalization of nav1.2 channel subtypes in rat and cat brain and spinal cord with high affinity antibodies. Brain Res., 1107(1), 1-12.

Dr. Engisch

 

Wang, X., Engisch, K. L., Teichert, R. W., Olivera, B. M., Pinter, M. J., & Rich, M. M. (2006). Prolongation of evoked and spontaneous synaptic currents at the neuromuscular junction after activity blockade is caused by the upregulation of fetal acetylcholine receptors. J. Neurosci., 26(35), 8983-8987.

Dr. Fyffe

 

Adragna, N. C., Ferrell, C. M., Zhang, J., Di Fulvio, M., Temprana, C. F., Sharma, A., Fyffe, R. E., Cool, D. R., & Lauf, P. K. (2006). Signal transduction mechanisms of k+-cl- cotransport regulation and relationship to disease. Acta Physiol. (Oxf), 187(1-2), 125-139.

 

Leao, K.E., Leao, R. N., Sun, H., Fyffe, R. E., & Walmsley, B. (2006a). Hyperpolarization-activated currents are differentially expressed in mice brainstem auditory nuclei. J. Physiol., 576(Pt 3), 849-864.

 

Leao, R. N., Sun, H., Svahn, K., Berntson, A., Youssoufian, M., Paolini, A. G., Fyffe, R. E., & Walmsley, B. (2006b). Topographic organization in the auditory brainstem of juvenile mice is disrupted in congenital deafness. J. Physiol., 571(Pt 3), 563-578.

 

Walmsley, B., Berntson, A., Leao, R. N., & Fyffe, R. E. (2006). Activity-dependent regulation of synaptic strength and neuronal excitability in central auditory pathways. J. Physiol., 572(Pt 2), 313-321.

Dr. Gomez-Cambronero

 

Di Fulvio, M., Lehman, N., Lin, X., Lopez, I., & Gomez-Cambronero, J. (2006). The elucidation of novel sh2 binding sites on pld2. Oncogene, 25(21), 3032-3040.

 

Lehman, N., Di Fulvio, M., McCray, N., Campos, I., Tabatabaian, F., & Gomez-Cambronero, J. (2006). Phagocyte cell migration is mediated by phospholipases pld1 and pld2. Blood, 108(10), 3564-3572.

Dr. Halm

 

Halm, S. T., Liao, T., & Halm, D. R. (2006). Distinct k+ conductive pathways are required for cl- and k+ secretion across distal colonic epithelium. Am. J. Physiol. Cell Physiol., 291(4), C636-C648.

Dr. Rich

 

Khan, J., Harrison, T. B., Rich, M. M., & Moss, M. (2006). Early development of critical illness myopathy and neuropathy in patients with severe sepsis. Neurology, 67(8), 1421-1425.

 

Teener, J. W., & Rich, M. M. (2006). Dysregulation of sodium channel gating in critical illness myopathy. J. Muscle Res. Cell Motil., 27(5-7), 291-296.

Dr. Wyatt

 

Buckler, K. J., Williams, B. A., Orozco, R. V., & Wyatt, C. N. (2006). The role of task-like k+ channels in oxygen sensing in the carotid body. Novartis Found. Symp., 272, 73-85; discussion 85-94, 131-140.

 

Evans, A. M., Hardie, D. G., Galione, A., Peers, C., Kumar, P., & Wyatt, C. N. (2006a). Amp-activated protein kinase couples mitochondrial inhibition by hypoxia to cell-specific ca2+ signalling mechanisms in oxygen-sensing cells. Novartis Found. Symp., 272, 234-252; discussion 252-238, 274-239.

 

Evans, A. M., Mustard, K. J., Wyatt, C. N., Dipp, M., Kinnear, N. P., & Hardie, D. G. (2006b). Does amp-activated protein kinase couple inhibition of mitochondrial oxidative phosphorylation by hypoxia to pulmonary artery constriction? Adv. Exp. Med. Biol., 580, 147-154; discussion 351-149.

 

Wyatt, C. N., Kumar, P., Aley, P., Peers, C., Hardie, D. G., & Evans, A. M. (2006). Does amp-activated protein kinase couple hypoxic inhibition of oxidative phosphorylation to carotid body excitation? Adv. Exp. Med. Biol., 580, 191-196; discussion 351-199.

 

2.  Presentations and invited talks

 

Dr. Brown

 

Innexus Biotechnologies and the University of Kentucky.  Cellular Paradigms of Signal Transduction

 

University of Kentucky College of Medicine, Department of Microbiology, Immunology, and Molecular Genetics and Immpheron, Inc., Regulation of Apoptotic Cell Death: Defining Avenues for Therapeutic Intervention

Dr. Cope

 

Dept. of Physiology, Northwestern University, Chicago, IL “Estimating PIC From Paired-unit Firing in Decerebrate Cats”

 

Dept. of Physiology, University of Wisconsin, Madison, WI  “Injury Signals in Synaptic Plasticity”

 

Dept. of Kinesiology Action Club, Penn State University, Philadelphia, PA  “Functional Assemblies of Motor Units “The Limits of Regeneration (Post-Regeneration Constraints on Recovery)”

 

Indiana University School of Medicine, Stark Neurosciences Research Institute

Dr. Fyffe

 

Steamboat Springs, CO 39th Annual Winter Conference on Brain Research Panel Organizer and Session Chair

 

Copenhagen, Denmark, Copenhagen Motoneurone Meeting “Reorganization of membrane ion channels inmotoneurons following axotomy”

 

University of Leeds, UK, Dept. of Neuroscience “Voltage-gated potassium channels in motoneurons”

 

Indiana University School of Medicine, Stark Neurosciences Research Institute “Kv2.1 channel clustering in motoneurons”

Dr. Gomez Cambronero

 

39th National Meeting, Society Leukocyte Biology. San Antonio, TX, Phospholipase D is involved in chemotaxis.

 

Wells Research Center, Indiana University School of Medicine, Indianapolis, IN; Molecular Basis of Leukocyte Inflammation:A Kinase/Phospholipase Interplay

Dr. Halm

 

Dayton Area Pathology meeting, Dayton OH, Intestinal Secretions: Ions, Water and Mucus.

 

Lake Cumberland Biological Transport Group Meeting, Cryptic rafting during secretory signaling.

Dr. Miska

 

The Buckeye Area Chapter of the American Association for Medical Transcription

Dr. Putnam

 

Department of Zoology, University of British Columbia, Vancouver, Canada

 

pH, CO2 and the Brain meeting sponsored by the Finnish Graduate School of Neuroscience, Helsinki, Finland

 

Dunaway/Burnham invited lecture at the Department of Physiology, Dartmouth Medical School, Hanover, NH

Dr. Rich

 

European Muscle Conference, Heidelburg, Germany, Dysregulation of sodium channel gating in Critical Illness Myopathy

Dr. Wooley

 

Harvard Medical School, Boston, MA, Department of Microbiology and Molecular Genetics

 

25th Annual Meeting, American Society for Virology, Madison, WI. A new phenotypic assay for HIV-1-infected patients

 

Tri-Service (Air Force, Army, Navy) Biomarker and Biomonitor Conference, Fairborn, OH, Genomic Biomarkers for Early Detection of Threat Exposure

 

3.  Invitations to participate or chair symposia

 

Dr. Fyffe

Central Research Forum, School of Medicine

 

Dr. Wooley

Annual GLRCE Meeting, Hilton Head, SC, Session Chair for Virology


4.  Editorial board memberships

 

Dr. Brown

 

American Journal of Physiology-Cell Physiology

Dr. Goldfinger

 

J. Integrative Neuroscience

Dr. Halm

 

American Journal of Physiology: Cell Physiology

Dr. Putnam

 

American Journal of Physiology: Cell Physiology

 

5.  Granting Agency Study Section Memberships

 

Francisco J. Alvarez

 

National Institute of Health, Sensory Motor Integration Study Section, regular member

Nancy J. Bigley

 

Alzheimers Foundation

Thomas L. Brown

 

National Science Foundation-Molecular & Cellular Biosciences Program

Julian Gomez Cambronero

 

American Heart Association Research Consortium, Panel for Molecular Signaling, Basic Cell and Mol Biol

 

NIH, Innate Immunity and Inflammation (III) Study Section

Timothy C. Cope

 

Ad Hoc member NIH Study Section

Adrian Corbett

 

American Heart Association (Ohio Valley Affiliate) grant review panel section 4A

 

Robert E.W. Fyffe

 

External Scientific Advisory Board, NIH Center of Biomedical Research Excellence (COBRE), University of North Dakota (Site visit, Nov 30-Dec 03, 2006); COBRE internal seed grant reviews

 

NIH Study Section Member – Interdisciplinary Center Core Grants (Neuroscience Blueprint; NINDS ZNS1 SRB-W 20 Study Section)

 

NSF Grant proposal review

Dan R. Halm

 

NIH Special Emphasis Panel

Robert W. Putnam

 

Lytmos Consulting Group, LLC

Dawn P. Wooley

 

NIH/NIAID GLRCE Study Section

 

6.  Offices held in National professional organizations

 

Dr. Bigley

 

American Academy of Microbiology, Abbott Laboratories Award in Clinical and Diagnostic Immunology Nominating Committee.  This award honors a distinguished scientist in clinical or diagnostic immunology for outstanding contributions.

Dr. Halm

 

Ohio Physiological Society, Treasurer

Dr. Wooley

 

NIH/NIAID Region V "Great Lakes,” Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research, Executive Board Member

 

7.  Special events, symposia or colloquia

 

None

 

8.  Faculty who were awarded professional development leave

 

 

None

 

9.  Faculty, staff or students who were given awards locally, nationally or internationally

 

Faculty

 

Dr. Cambronero

 

Outstanding Achievement in Medical Education and Research Award, Academy of Medicine, Dayton

Dr. Miska

 

2006 National Society of Collegiate Scholars Faculty of the Year Award Nomination.

Dr. Wyatt

 

Finalist in the young investigator awards, 10th Oxford Conference, Modeling and the Control of Breathing, Lake Louise, Canada

 

 

Students

 

Jessica Hoying

 

2006 Student Excellence Award, Anatomy, School of Graduate Studies, WSU

Adam Deardorff

 

2006 Galen Award, scholastic excellence in anatomy, Department of Neuroscience, Cell Biology and Physiology, WSU

 

10.  Outreach programs

 

Dr. Alvarez

 

Tour of Electron Microscopy facility Troy Christian High School students, one-day event in spring

Dr. Bigley

 

Mentored (with Ken Frey) a High School science project (Derek Smith) that won top awards at all levels including the state level.

Dr. Fyffe

 

               Miami Valley School Board of Trustees

               University Honors Institute – Neuroscience/CBR Information Booth

               Miami Valley School – senior’s career day

Dr. Miska

 

Exploring Human Anatomy: An Interactive Anatomy Lab Experience.  The functions of the major organs and organ systems of the human body were presented using preserved human specimens, included healthy and diseased organs.  Presentations were given to over 1000 high school and technical college students.

 

Miami Valley Career Technology Center (19 students) January 9

Springfield Shawnee High School (22 students) January 11

Fort Jennings High School (25 students) March 1

Northmont High School (50 students) April 3

Northmont High School (50 students) April 5

Beavercreek High School (40 students) April 7

Chaminade-Julienne High School (30 students) April 10

Carroll High School (30 students) April 12

Ivy Tech State College (20 students) April 14

Fairmont High School (50 students) April 17

Fairmont High School (50 students) April 19

Beavercreek High School (40 students) April 21

Miami Valley Career Technology Center (20 students) April 24

Lakota East High School (45 students) April 24

Alter High School (40 students) April 26

Lakota East High School (45 students) April 26

West Carrollton High School (30 students) April 28

Carroll High School (30 students) May 1

CTC (20 students) May 3

Springfield North High School (30 students) May 5

Springfield JVS (25 students) May 8

Monroe High School (40 students) May 10

Green County Career Center (20 students) May 12

Green County Career Center (25 students) May 15

Reading High School (10 students) May 17

Centerville High School (15 students) May 19

Franklin High School (25 students) May 22

Centerville High School (40 students) May 24

St. Henry High School (25 students) May 26

Springfield Shawnee High School (25 students) June 5

Darke County Developing New Physicians' Medical Summer Camp (10 students) June 9

Miami Jacobs Career College (10 students) June 19

Miami Jacobs Career College (10 students) June 21

RETS Tech (35 students) July 14

Miami Valley Career Technology Center (30 students) August 9

Greenville High School (10 students) October 23

Green County Career Center (20 students) October 25

Miami Valley Career Technology Center (5 students) October 30

WSU Biology Honors Students (15 students) November 8

WSU Biology Honors Students (15 students) November 9

Ridgeville Christian High School (10 students) November 15

Southwestern College (30 students) November 22

Miami Valley Career Technology Center (35 students) November 27

 

Dr. Nieder

 

Horizons in Medicine – directed medical students in the instruction of HS students for the one week anatomy segment

Dr. Pearson

 

Mini-Med School Neuroscience teaching demonstration

 

11.  Student clubs and activities

 

None

 

12.  Undergraduate honors students

 

Roger Fecher

 

Mentor: Dr. Robert Fyffe, “Activity dependent modulation of KV2.1 channels”

 

13.  Off campus or special interest courses

 

Dr. Wooley

 

Biosafety, taught on campus, educates people how to work       safely with biological hazards

 

Dr.  Rich

 

Summer lectures in the Neurology course for psychiatry residents at Elizabeth Place

 

14.  Graduate students

 

Jordan Bohnic, “Role of platelet-rich plasma in acceleration of bone fracture healing,” entering medical school Toledo

 

D’Wan Carpenter

 

Susan Conrad, “Development of chemosensitivity in neurons from the nucleus tractus solitarius (NTS),” year two medical student, WSU Boonshoft SOM

 

Trevor Downing, “The relationship between lactic acid, reactive oxygen species and the hypoxia-induced acidification seen in chemosensitive neurons of the nucleus tractus solitarius (NTS),” year one medical student, WSU Boonshoft SOM

 

Eileen FitzSimons, “Progression of amyotrophic lateral sclerosis: changes in the recurrent inhibiting circuit of G93A SOD-1 mice”

 

Amy Gultice, “Hypoxia inhibits trophoblast giant cell differentiation”

 

Jessica Hoying, “The role of hyaluronic acid treatment in the prevention of keloid formation,” year one medical student, WSU Boonshoft SOM

 

McMillan, Patricia, “The distribution and expression of the G-protein-activated inward rectifying potassium channel subunits: GIRK-1 (Kir 3.1), GIRK-2 (Kir 3.2) and GIRK-3 (Kir3.3) in the rodent spinal cord”

 

Nadia Regis

 

John Roebel, “developmental expression of calcium-binding proteins in the AVCN and MNTB of normal hearing and congentially deaf mice,” year one medical student, WSU Boonshoft SOM

 

Holly Short, “Prefrontal activation and volume in a group of never-medicated schizophrenics: an examination of gray and white matter by Brodmann areas,” entering PA school in Kentucky

 

Nathan Smith, year one medical student, WSU Boonshoft SOM

 

Ethan Stoll, in osteopathic medical school in Florida

 

Farnaz Tabatabaian, “The measurement of endogenous mRNA expression of PLD isoforms in HL-60 cells using QRT-PCR and the impact of these isoforms on gene expression of mTOR and S6K,” in medical school Illinois

 

Cynthia Wingert, “CD11b+ microglia in the trigeminal ganglion of immunized BMB/c mice following ocular challenge with HSV-1,”  faculty, Cedarville University