Department of: Biochemistry and Molecular Biology

 

Chair: Daniel T. Organisciak, Ph.D.

 

Phone: 937-775-3041


E-mail: BMB@wright.edu

 

 


1.  Refereed publications and book chapters

 

Dr. Alter

 

            J. Nuss, D. Sweeney, and G.M. Alter, 'Reactivity-based Analysis of Domains

                        Structures in Native Replication Protein A', Biochemistry, 45, 9804-9818,

                        2006.

Dr. Berberich

 

            K. Heminger, M. Kadakia, B. Dwarakanth and S.J. Berberich, 'Altered Gene

                        Expression Induced by Ionizing Radiation and Glycolytic Inhibitor 2

                        dexoyÑglucose in a Human Glioma Cell Line: Implications for Radio

                        Sensitization', Cancer Biology & Therapy, 5, 815-823, 2006.

            D. Paull, K. Heminger, and S.J. Berberich, 'Invited Commentary on Tsubochi et.al.,

                        Annals of Thor. Surgery, 82, 1204, 2006.

Dr. Kadakia

 

            K. Heminger, V. Jain, M. Kadakia, B. Dwarkanath, S.J. Berberich, 'Altered Gene

                        Expression Induced by Ionizing Radiation and Glycolytic Inhibitor 2-deoxy

                        glucose in a Human Glioma Cell Line: Implications for Radio Sensitization.',

                        Cancer Biol Ther, 5, 815-823, 2006.

            R. Kommagani, T.M. Caserta, M.P. Kadakia, 'Identification of Vitamin D

                        Receptor as a Target of p63', Oncogene, 25, 1-7, 2006.

            T.M. Caserta, R. Kommagani, Z. Yuan, D. Robbins, C.Mercer, M. Kadakia, 'p63

                        Overexpression Induces the Expression of Sonic Hedgehog', Molecular Cancer

                        Research, 4, 759-768, 2006.

Dr. Leffak

 

            G. Ghosh, M. Ritzi, M. Kemp, A. Schepers, G. Liu, M. Leffak, 'Differential Binding

                        of Replication Proteins Across the Human c myc Replicator.', Molecular &

                        Cellular Biology, 26, 5270-5283, 2006.

            V. Potaman, M. Pytlos, V. Hashem, J. Bissler, M. Leffak, and R. Sinden, 'DNA

                        Structures and Genetic Instabilities Associated with SCA10 (ATTCT)n

                        (AGAAT)n  Repeats Suggests a DNA Amplification Model for Repeat

                        Expansion ', Genetic Instabilities and Neurological Diseases, 447-460,

                        2006.  

Dr. Liu

 

            S.J. Gray , G. Liu, A.L. Altman, L.E. Small, and E. Fanning, ‘Discrete Functional

                        Elements Required for Initiation Activity of the Chinese Hamster

                        Dihydrofolate Reductase Origin Beta at Ectopic chromosomal Sites’, Exp. Cell

                        Res. Epub Sept. 28, 2006.

            M. Ghosh, M. Kemp, G. Liu, M. Ritzi, A. Schepers, and M. Leffak, ‘Differential

                        Binding of Replication Proteins Across the Human c-myc Replicator. Mol Cell

                        Biol., 26, 5270-5283, 2006.

Dr. Organisciak

 

            B.W. Jones, R.E. Marc, C.B. Watt, D.K. Vaughan, D.T. Organisciak, 'Neural

                        Plasticity Revealed by Light-Induced Photoreceptor Lesions.’ Advances in

                        Experimental Medicine and Biology, Eds. J.G. Hollyfield, R.E. Anderson,

                        M.M. LaVail, Vol. 572 Springer, N.Y., 405-410, 2006.

            D.T. Organisciak, R. Darrow, Xiaorong Gu, L. Barsalou, J. Crabb, 'Genetic, Age and

                        Light Mediated Effects on Crystallin Protein Expression in the Retina',

                        Photochem. Photobiol., 82, 1088-1096, 2006.

            M. Sun, S.C. Finnemann, M. Febbraio, L. Shan, S.P. Annangudi, E.A. Podrez, G.

                        Hoppe, R. Darrow, D.T Organisciak, R.G. Salomon, R.L. Silverstein, S.L.

                        Hazen, 'Light-induced Oxidation of Photoreceptor Outer Segment

                        Phospholipids Generates Ligands for CD36-mediated Phagocytosis by Retinal

                        Pigment Epithelium: A Potential Mechanism for Modulating Outer Segment

                        Phagocytosis Under Oxidant Stress Conditions', J. Bio. Chem., 281, 4222

                        4230, 2006.

            R. Grewal, D. Organisciak, P. Wong, 'Factors Underlying Circadian Dependent

                        Susceptibility to Light Induced Retinal Damage.’ Advances in Experimental

                        Medicine and Biology, Eds. J.G. Hollyfield, R.E. Anderson, M.M. LaVail.,

                        Vol. 572 Springer, N.Y. , 411-416, 2006.

            T. Duncan, B. Wiggert, N. Wittaker, R. Darrow, D.T. Organisciak, 'Effect of Visible

                        Light on the Retinoids in Normal and P23H-3 Transgenic Rat Retina:

                        Characterization of a Novel Retinoic Acid Derivative Present in P23H-3

                        Retina', Photochem. Photobiol. , 82, 741-745, 2006.

            V. Palamalai, R.Darrow, D.T. Organisciak, M. Miyagi, 'Light-induced Changes in

                        Protein Nitration in Photoreceptor Rod Outer Segments', Molecular Vision, 12,

                        1543-1551, 2006.                   

Dr. Reo

 

            B. Kuczynski and N. V. Reo, 'Evidence that Plasmalogen Protects Against Oxidative

                        Stress in the Rat Brain In Vivo', Neurochemical Research, 31, 639-656, 2006.

            W. C. Chumlea, C. M. Schubert, N. V. Reo, S. S. Sun and R. M. Siervogel, 'Total

                        Body Water for White Children and Adolescents and Anthropometric

                        Prediction Equations: The Fels Longitudinal Study', Kidney International, 68,

                        2317-2322, 2005.

Dr. Seybold

            P.G. Seybold, ‘QSPR Analysis of Solvent Effects on the Decay of the 1g State of                                Molecular Oxygen’, Internet Electronic Journal of Molecular Design 5, 479-487.                           2006.

 

            P.G. Seybold, M.J. O’Malley, L.B. Kier, and C.K. Cheng, ‘Cellular Automata                                                 Stimulations of Vapor-Liquid Equilibria’, Australian J. Chem. 59, 865-868. 2006.

 

 

2.  Presentations and invited talks

 

Dr. Alter

            G. Alter, J. Nuss, J. Oberoi, T. Christian, M. Raymer, High Confidence Prediction of

                        the Three Dimensional Structure of Replication Protein A, 8th Annual Midwest

                        DNA Repair Meeting, Indianapolis, IN 6/3/2006 - 6/4/2006 (Poster).

            P. Anterson, L. MItchell, T.Christian, M. G. Alter, M. Raymer, Protein Structure

                        Probing Through Limited Proteolysis, Ohio Collaborative Conference on

                        Bioinformatics, Athens, OH 6/28/2006 – 6/30/2006 (Poster).

            D. Sweeney, M. Raymer, G. Alter, Automation of Data Extraction in Chemical

                        Reactivity Analysis Experiments, Ohio Collaborative Conference on

                        Bioinformatics, Athens OH 6/28/2006 - 6/30/2006 (Poster).

           

                        Presentations

            High Confidence Structure Predictions Using M-ran, Ohio Collaborative Conference on                                    Bioinformatics, Athens OH, 6/28/2006 - 6/30/2006.

 

            Protein Structures:  Reverse Engineering Molecular Machines, Hiram College,

                        Hiram OH, 10/26/2006.

Dr. Berberich

                        Presentations

            Altered Gene Expression Induced by Ionizing Radiation and Glycolytic Inhibitor 2

                        dexoy-glucose in a Human Glioma Cell Line: Implications for Radio

                        Sensitization., 1st International Conference on 2-deoxy-D-glucose, Delhi,

                        India, 11/6/2006 - 11/12/2006.

            Deciphering the MdmX Network: p53, Mdm2 and Beyond, Virginia Commenwealth

                        University- Cancer Center, Richmond, VA, 4/4/2006 - 4/5/2006.

            Deciphering the MdmX Network: p53, Mdm2 and Beyond, MD Anderson Cancer

                        Center, Houston TX, 5/4/2006 - 5/5/2006.

            Deciphering the MdmX Network: p53, Mdm2 and Beyond, BMB Department,

                        Wright State University, Dayton, OH, 6/6/2006 - 6/9/2006.

            The p53 Tumor Suppressor Gene: Mutations are Only Half the Story., Pathology

                        Department, Wright State University, Dayton, OH, 11/1/2006.

Dr. Kadakia

            R. Kommagani, T.M. Caserta, M.P. Kadakia, Regulation of Vitamin D Receptor

                        Pathway by p63 and its Implications on VitaminD3 mediated Differentiation,

                        13th Workshop on Vitamin D, Victoria, BC Canada 4/8/2006 – 4/12/2006

                        (Poster).

            T.M. Caserta, R. Kommagani, Z.Yuan, D.Robbins, C.l Mercer, M. Kadakia, p63g

                        induces the expression of Sonic Hedgehog, 13th Annual p53 Workshop,

                        Columbia University 5/20/2006 – 5/24/2006 (Poster).

            S.K. Khokhar, T.M. Caserta, R. Kommagani, M.P. Kadakia, Effect of p63 on p53

                        Mediated transactivation, 13th Annual p53 Workshop, Columbia University

                        5/20/2006 – 5/24/2006 (Poster).

            R. Kommagani, T.M. Caserta, M.P. Kadakia, Regulation of Vitamin D Receptor

                        pathway by p63, 13th Annual p53 Workshop, Columbia University  5/20/2006

                        - 5/24/2006 (Poster).

            J.E. Van Nostrand,C.S. Levin, J.M. Slocik, J.D. Hartgerink, N.J. Halas,

                        M.P.Kadakia, and R.R. Naik , Biofunctionalized Nanoshells for Biological

                        Detection, AVS 53rd International Symposium (San Francisco, CA) 11/12/

                        2006 – 11/17/2006 (Platform).

            M.Gupta1, D.M. Phillips, T.M. Caserta, L.A. Sowards, L.F. Drummy, M.P. Kadakia

                        and R.R. Naik, Micropatterned Silk Films for Cell Growth., Materials Research

                        Society meeting, San Francisco, CA 4/17/2006 – 4/21/2006 (Platform).          

 

                        Presentations

            Role of p63 in Cancer and Development, University of Dayton, University of

                        Dayton, Dept. of Biology, 3/23/2006.

Dr. Leffak

            M. Leffak, Cellular Models of DNA Replication-Related Human Disease, Gene

                        Therapy and Molecular Biology, Crete, Greece 9/2/2006 – 9/8/2006

                        (Platform).

 

                        Presentations

            Drug Interactions with the c-myc DNA Unwinding Element Binding Protein

DUE-B, Laboratory of Clinical Investigation, Drug Discovery Branch, NIH, Washington, D.C., 3/31/2006.

Dr. Organisciak

            R.M. Kelln, M.A. Chrenek, R. Darrow, D.T. Organisciak, V. Vasireddy, R.

                        Ayyagari, P. Wong, Cellular Localization of 1363, an Uncharacterized Gene

                        Identified in a Screen for Differentially Expressed Light Induced Retinal

                        Degeneration Genes in the Rat, The Association for Research in Vision and

                        Ophthalmology, Ft. Lauderdale, FL 4/30/2006 - 5/4/2006 (Poster).

            M. Miyagi, V. Palamalai, R.M. Darrow, D.T. Organisciak, Comparative Proteome

                        Analysis of Light Exposed and Unexposed Photoreceptor Rod Outer Segments,

                        The Association for Research in Vision and Ophthalmology, Ft. Lauderdale,

                        FL 04/30/2006 - 05/04/2006 (Poster).

            D.T. Organisciak, R.M. Darrow, L.S. Barsalou, B. McDonald, P. Wong, Circadian

                        and Stress Induced Changes in Rod Outer Segment Crystallins, The

                        Association for Research in Vision and Ophthalmology, Ft. Lauderdale, FL

                        04/30/2006 - 05/04/2006 (Poster).

            M. Chrenek, A.C. Ziesel, R.M. Darrow, L. Barsalou, D.T. Organisciak, P.Wong,

                        Differential Expression of Cope During Light Induced Retinal Damage in

                        Rats, The Association for Research in Vision and Ophthalmology, Ft.

                        Lauderdale, FL 04/30/2006 - 05/04/2006 (Poster).

 

            Presentations

            Age Related Vision Loss, Focus on Healthy Aging, Wright State University,

                        Dayton, OH, 10/24/2006.

Dr. Paliy

            O. Paliy, N. Kelley-Loughnane, S. Trott, J. Lynch, E. Lester, B. Foy, and J. Frazier,                             Cell-Like Entity: stable, non-living biological construct, Synthetic Biology                          v2.0, Berkeley, CA 05/19/2006 - 05/22/2006 (Poster).

Dr. Prochaska

            T.L. Cvetkov, L.A. Shroyer, and L. J. Prochaska, Biophysical and biochemical

                        properties of Rhodobacter sphaeroides cytochrome c oxidase in purified

                        phospholipids vesicles,  Biophysical Society, Salt Lake City, UT  2/16/2006 –

                        2/20/2006 (Poster).

            T.L. Cvetkov, L.A. Shroyer, and L. J. Prochaska, Biophysical and biochemical

                        properties of Rhodobacter sphaeroides cytochrome c oxidase in purified

                        phospholipids vesicles, Gordon Research Conference on Molecular and

                        Cellular Bioenergetics, Andover, NH 6/17/2006 - 6/21/2006 (Poster).

 

            Presentations

            Biophysical and Biochemical Properties of Rhodobacter Sphaeroides Cytochrome C

                        oxidase in Purified Phospholipids Vesicles., Gordon Research Conference on

                        Molecular and Cellular Bioenergetics, Andover, NH, 6/17/2006 - 6/21/2006.
Dr. Reo

            D.A. Mahle, N.J. DelRaso, M.L. Raymer, A.E. Neuforth, M.P. Westrick and N.V.

                        Reo, Combined Urine and Plasma Metabolomic Analysis of a

napthylisothiocyanate (ANIT) Liver Toxicity in the Rat., Metabolomics Society Second Scientific Meeting, Boston, MA 6/24/2006 - 6/29/2006 (Poster).

            J. Hollyfield, J. Dean, R. Putnam and N.V. Reo, Effects of Oxygen Toxicity on Rat

                        Brain Metabolism: A NMR Study, Central Research Forum, Wright State

                        University 2/9/2006 – 2/9/2006 (Poster).

            M. Kent, D. Boverhof, T. Zacharrewski, and N V. Reo, A NMR Metabolomics

                        Analysis of Dioxin-Induced Changes in a Mouse Model, Central Research

                        Forum, Wright State University 2/9/2006 – 2/9/2006 (Poster).

            D.A. Mahle, N.J. DelRaso, S.C. Gustafson, C.L. Leakeas, M.P. Westrick, A.E.

                        Neuforth and N.V. Reo, Comparison of Plasma and Urine Samples from

                        ANIT-Exposed F344 Rats Using NMR Spectroscopy, Central Research Forum,

                        Wright State University 2/9/2006 – 2/9/2006 (Poster).

            M. Kent, N.V. Reo, G.L. Jahns, V. DelRaso, D. Boverhof, L. Burgoon, D. Jump and

                        T. Zacharewski, Metabolomic Analysis of Lipid and Aqueous Liver Extracts in

                        TCDD-Treated Mice, Empowering Environmental health Sciences Research

                        with New Technologies, A Conference on Omic Applications in the

                        Environment Health Sciences, Chapel Hill, NC 12/4/2006 – 12/6/2006

                        (Platform).

 

            Presentations

                        NMR Studies of Tissue Phospholipid Metabolism in Toxicology, Department of

Environmental Health, University of Cincinnati, 5/31/2006.  Tissue Phospholipid Metabolism, Department of Pharmacology and Toxicology, Wright State University, 5/24/2006.

 

3.  Invitations to participate or chair symposia

 

Dr. Alter

 

                Ohio Collaborative Conference on Bioinformatics (OCCBIO), Reactivity

                        Based Prediction of a Multi-domain Protein, Replication Protein A,

                        6/28/2006 - 6/30/2006, Athens OH. (Session Chair)

 

4.  Editorial board memberships

 

            None

 

5.  Granting Agency Study Section Memberships

 

Dr. Alter

 

            American Heart Association

 

            National Science Foundation

Dr. Berberich

 

            National Science Foundation

 

            National Cancer Institute (NIH)-Jan 06: Cancer Molecular Pathobiology Study                                                 Section

 

            National Cancer Institute (NIH)-Oct 06: Cancer Molecular Pathobiology Study

                        Section

 

            Targeted Protein Assessment- Mdm2

 

            WSU Research Challenge

Dr. Kadakia

 

            Air Force Office of Scientific Research

 

            Breast Cancer Campaign

Dr. Leffak

 

            Israel Cancer Research Foundation      

Dr. Paietta

 

            National Science Foundation

Dr. Prochaska

 

            American Chemical Society-Petroleum Research Fund

 

            American Heart Association Ohio Valley/Southern Affiliate

 

6.  Offices held in National professional organizations

 

Dr. Kadakia  

 

            Associate member in the American Association of Cancer Researchers

Dr. Organisciak

 

            Academy of Medicine Board of Trustees (1998-2008)

 

            Board of Governors Ohio BRTT project on Age Related Macular Degeneration appointed                    (2005-2008)

 

            Board of Trustees Sinclair Community College Biotechnology Program (2003-)

 

            Guest Editorial Board Member, Investigative Ophthalmology and Visual Science

 

            Trustee Biochemistry and Molecular Biology, Association for Research in Vision and                             Ophthalmology (ARVO) elected 2002-2007 (Vice President 2006-2007)

Dr. Prochaska

 

            Board of Directors, American Heart Association, Miami Valley, Dayton

 

            Chair of American Heart Association Ohio Valley-Southern Consortium, Peer Review                           Study Section on Molecular Biology

 

            Secretary/Treasurer Sigma Xi- WSU Chapter

 

            Treasurer of Bioenergetics subgroup of the Biophysical Society-elected position 2005-                          2007

Dr. Alter

 

            Consultantships: Intrexon Corp., Roanoke, VA

Dr. Paliy

 

Consultantships: Sergey Gazenko, NovaLogix, Inc.

 

7.  Special events, symposia or colloquia

 

         Winter Quarter 2006:

            Dr. Kathrin Engisch, Dept. of Neuroscience, Cell Biology and Physiology, Wright State

                        University

 

            Dr. Dawn Chandler, Department of Pediatrics, The Ohio State University School of

                        Medicine and Public Health

 

            Dr. Elsa Flores, Department of Molecular and Cellular Oncology, The University of                               Texas M.D. Anderson Cancer Center

 

            Dr. Timothy Cope, Dept. Of Neuroscience, Cell Biology and Physiology, Wright State

                        University        

 

            Dr. John Rowe, Department of Biology, University of Dayton

 

            Dr. Frank Soennichsen, Department of Physiology and Biophysics, Case Western                                             Reserve University

 

            Dr. Richard Sinden, Center for Genome Research, Institute of Biosciences and                                      Technology, Texas A&M University

 

         Spring Quarter 2006:

            Dr. George Thomas, GRI-Genome Science, University of Cincinnati

 

            Dr. Laszlo Csonka, Department of Biological Sciences, Purdue University

 

            Dr. Julian Cambronero, Dept. of Neuroscience, Cell Biology and Physiology, Wright                             State University

 

            Dr. Anja-Katrin Bielinsky, Department of Biochemistry, Molecular Biology and

                        Biophysics, University of Minnesota Medical School

 

            Dr. Han-Fei Ding, Department of Biochemistry and Cancer Biology, Medical University                                    of Ohio    

           

            Dr. Andrew Herr, Department of Molecular Genetics, Biochemistry and Microbiology,

                        University of Cincinnati

 

            Dr. Daniel T. Organisciak, Department of Biochemistry and Molecular Biology, Wright

                        State University

 

            Dr. Steve Berberich, Department of Biochemistry and Molecular Biology, Wright State

                        University        

        

          Fall Quarter 2006:

            Dr. Amy Davidson, Department of Chemistry, Purdue University          

 

            Dr. Hua Lu, Department of Biochemistry and Molecular Biology, Oregon Health and

                        Sciences University

 

            Dr. Paul R. Andreassen, Department of Pediatrics, Cincinnati Children’s Hospital                                              Medical Center

 

            Dr. Yue Zou, Department of Biochemistry and Molecular Biology, East Tennessee State

                        University        

 

            Dr. John Kopchick, Department of Biomedical Sciences, Ohio University         

 

            Dr. Timothy Zacharewski, Department of Biochemistry and Molecular Biology,                                                 Michigan State University

 

8.  Faculty who were awarded professional development leave

 

None

 

9.  Faculty, staff or students who were given awards locally, nationally or internationally

 

            Cheryl K. Little received the President’s Award for Excellence in Leadership.

 

            Dr. Nicholas Reo received the SOM Student’s Teaching Award.

 

10.  Outreach programs

 

 

         Dr. Organisciak participated in Mini-Med. School at Wright State University,

                    Dayton, OH, “Age Related Vision Loss, Focus on Healthy Aging,” 10/24/2006.

11.  Student clubs and activities

 

            none

 

12.  Undergraduate honors students

           

            none

 

13.  Off campus or special interest courses

 

            None

 

14.  Graduate students

 

Dr. Alter

            Twinkle Christian, M.S., Use of Chemical and Enzymatic Modifications to Aid in the                            Analysis of Protein Three Dimensional Structures”, working in California.

 

Dr. Leffak

            Michael Kemp, Ph.D., "Regulation of DNA Replication Initiation By Histone                                         Acetylation and the DNA Unwinding Element Binding Protein Due-B", Univ. of                               North Carolina, Chapel Hill.

 

Dr. Paliy

            Kruthi Murthy, M.S. (M&I student), “Phenotypic Characterization of Escherichia coli                            Strains Isolated from Human Intestinal & Urinary Tracts”