Chair:
Dr. Daniel Organisciak, 937-775-3041
http://www.med.wright.edu/bmb/
Dr. Alter
J. Nuss, S. Patrick, G. Oakley, G. Alter, J.
Robison, K. Dixon, J. Turchi, ‘ DNA Damage Induced Hyperphosphorylation of
Replication Protein A. 1. Identification of Novel Sites of Phosphorylation in
Response to DNA Damage’, Biochemistry, 44, 8428-8437, 2005.
Dr. Berberich
M. Ghosh, K. Weghorst and S. Berberich, ‘MdmX
Inhibits ARF Mediated Mdm2 Sumoylation’, Cell Cycle, 4, 604-608, 2005.
Dr. Kadakia
R. Kommagani, T. Caserta, M. Kadakia, ‘Identification
of Vitamin D Receptor as A Target of p63’, Oncogene, 1-7, 2006.
S.M. Rozanzhak, M.P. Kadakia, T.M. Caserta, T.R.
Westbrook, M.O. Stone and R.R. Naik, ‘Cellular Internalization and Organelle
Targeting of Semiconductor Quantum Dots’, Chem. Commun. , 2217-2219, 2005.
Dr. Leffak
J. Casper, M. Kemp, M. Ghosh, G. Randall, A.
Vaillant and M. Leffak, ‘The c-myc
DNA Unwinding Element Binding Protein Modulates DNA
Replication in Vitro’, J. Biol. Chem., 280, 13071-13083, 2005.
M. Kemp, M. Ghosh, G. Liu, and M. Leffak, ‘The
Histone Deacetylase Inhibitor Trichostatin A Alters Replication Origin Activity
in Human Cells’, Nucleic Acids Research, 33, 325-336, 2005.
R. Moaddel, G.B. Price, J. Juteau, M. Leffak, and
I.W. Wainer, ‘The Synthesis and Initial Characterization of an Immobilized DNA
Unwinding Element Binding Protein Chromatographic Stationary Phase.’, J.
Chromatography, 820, 197-203, 2005.
Dr. Organisciak
Z. Ablonczy, R.M. Darrow, D.R. Knapp, D.T.
Organisciak, R.K. Crouch, ‘Rhodopsin Phosphorylation in Rats Exposed to Intense
Light’, Photochem. Photobiol., 81, 541-547, 2005.
Dr. Paliy
P. Gyaneshwar, O. Paliy, J. McAuliffe, A. Jones, M.
I. Jordan and S. Kustu, ‘Lessons from
Escherichia coli Genes Similarly Regulated in Response to Nitrogen and Sulfur Limitation’,
PNAS, 102, 3453-3458, 2005.
P. Gyaneshwar, O. Paliy, J. McAuliffe, D. L. Popham,
M.I. Jordan and S. Kustu, ‘Sulfur and Nitrogen Limitation in Escherichia coli
K12: Specific Homeostatic Responses’, J Bacteriology, 187, 1074-1090, 2005.
Dr. Patrick
J. E. Nuss, S. M. Patrick, G. Oakley, G. M. Alter,
J. G. Robison, K. Dixon, and J. J. Turchi, ‘DNA Damage Induced
Hyper-phosphorylation of Replication Protein A.
1. Identification of Novel Sites of Phosphorylation in Response To DNA Damage.’,
Biochemistry, 44, 8428-8437, 2005.
L. Zheng, M. Zhou, Q. Chai, J. Parrish, D. Xue, S.
M. Patrick, J. J. Turchi, , S. Yannone,
D. C. J. Chen, and B. Shen, ‘Novel Function of the Flap Endonuclease-1 Complex
in Processing DNA Replication Forks.’, EMBO Reports, 6, 83-89, 2005.
S. M. Patrick, G. G. Oakley, K. Dixon, and J. J.
Turchi, ‘DNA Damage Induced Hyper-Phosphorylation of Replication Protein A. 2. Characterization
of DNA Binding Activity, Protein Interactions
and Activity In DNA Replication and Repair’, Biochemistry, 44, 8438-8448, 2005.
Dr. Prochaska
D. Riegler, L.A. Shroyer, C. Pokalsky, D. Zaslavsky,
R. Gennis, and L.J. Prochaska , ‘Characterization of Steady-state Activities of
Cytochrome c Oxidase at Alkaline pH: Mimicking the Effect of K-channel Mutations
in the Bovine Enzyme., ‘Biochimica Biophysica acta, 2005.
Dr. Reo
B. Hoffman-Kuczynski and N. V. Reo, ‘Administration
of Myo-Inositol Plus Ethanolamine Elevates Phosphatidylethanolamine Plasmalogen
in the Rat Cerebellum’, Neurochemical Research, 30, 47-60, 2005.
Adjunct Faculty Published
Articles
Dr. Rubinson
Chinese translated edition of Contemporary Chemical
Analysis
Dr. Seybold
L.B. Kier, P.G. Seybold, and C.-K. Cheng, ‘Modeling
Chemical Systems Using Cellular Automata’, Springer: Dordrecht,
The Netherlands,
2005.
Abstracts/Presentations at Conferences
Dr. Kadakia
M.P. Kadakia, S.M. Rozanzhak, T.M. Caserta, T.R.
Westbrook, M.O. Stone and R.R. Naik, Cellular Internalization and Targeting of
Nanoparticles, 229th American Chemical Society National Meeting , San Diego,
CA 3/13/2005 - 3/17/2005 (Platform).
Dr. Leffak
M. Kemp, M. Ghosh,
N. Katrangi, and M. Leffak, Characterization of the c-myc DNA Unwinding Element
Binding Protein DUE-B, Cold Spring Harbor Meeting on Eucaryotic DNA
Replication, Cold Spring Harbor, N.Y.
9/7/2005 - 9/11/2005 (Poster).
S. Myers, G. Liu, R.R. Sinden, J. Bissler, and M. Leffak, Influence of Alternative
DNA Structures on c-myc Replicator Activity, Cold Spring Harbor Meeting on
Eucaryotic DNA Replication, Cold Spring Harbor, N.Y. 9/7/2005 - 9/11/2005 (Poster).
M. Leffak, M. Ghosh, M. Ritzi, A. Schepers, G. Liu, Differential Binding of Replication
Proteins Across the Human c-myc Replicator, Cold Spring Harbor Meeting on
Eucaryotic DNA Replication, Cold Spring Harbor, N.Y. 9/7/2005 - 9/11/2005 (Platform).
Dr. Organisciak
M. Chrenek,
M.L. Patterson, R.M. Darrow, D.T. Organisciak, P. Wong, Expression Profiles of
Stress Related Genes During Light-Induced Retinal Damage in Rats, The
Association for Research in Vision and Ophthalmology, Ft. Lauderdale, FL 4/30/2005 - 5/5/2005 (Poster).
V. Palamalai, R.T. Carruth, R.M. Darrow, P.A. Carr, D.T. Organisciak, M.
Miyagi, Light-Induced Protein Nitration in the Photoreceptor Rod Outer
Segments, The Association for Research in Vision and Ophthalmology, Ft.
Lauderdale, FL 4/30/2005 - 5/5/2005
(Poster).
B.D. Maciejko, M. Chambers, A. Blanchard, R. Darrow,
Y.Myal, D. Organisciak, P.Wong, Expression of Cited 2, a Gene Isolated From a
Light-Induced Retinal Degeneration cDNA Library, in the Degenerating Retina and
the Involuting Mammary Gland, The Association for Research in Vision and
Ophthalmology, Ft. Lauderdale, FL
4/30/2005 - 5/5/2005 (Poster).
R.M. Kelln, V. Vasireddy, R. Darrow, D.T. Organisciak,
R. Ayyagari, P. Wong Functional Analysis of a Novel Rat Retinal Expressed Gene
Associated with Light-Induced Retinal Degeneration, The Association for
Research in Vision and Ophthalmology, Ft. Lauderdale, FL 4/30/2005 - 5/5/2005 (Poster).
K. Renganathan, J. Gu, B. Gugiu, X.Gu, R. Darrow, H. Lewis, R.G. Salomon, D.T.
Organisciak, J.W. Crabb, Similarities in Plasma Oxidative Modifications from Retinal
Light Damage and AMD, The Association for Research in Vision and Ophthalmology,
Ft. Lauderdale, FL 4/30/2005 - 5/5/2005
(Poster).
D.T. Organisciak, K.M. Henkels, L.S. Barsalou, R.M.
Darrow, Hyperthermic Treatment Alters Rat Rod Outer Segment Crystallin Levels,
The Association for Research in Vision and Ophthalmology, Ft. Lauderdale,
FL 4/30/2005 - 5/5/2005 (Poster).
Dr. Paliy
J. Frazier, N. Kelley-Loughnane, S. Trott, J. Lynch,
E. Lester, O. Paliy, and B. Foy, Cell-Like Entity (CLE): Stable, Non-living
Biological Construct, QB3 Life Engineering Symposium, San Francisco, CA, USA,
San Francisco 8/19/2005 - 8/20/2005
(Poster).
Dr. Prochaska
R. Geyer, S. Patli, G.M. Alter, J.P. Hosler, and
L.J. Prochaska, Cytochrome c Oxidase Subunit I From Rhodobacter sphaeroides
Assumes an Alternative Conformation in the Absence of Subunit III. ,
Biophysical Society, Long Beach,
CA 2/16/2005 - 2/20/2005
(Platform).
Dr. Reo
G.L. Jahns, N. DelRaso, M. P. Westrick, V. Chen, N.V.
Reo and T. R. Zacharewski, Joint Genomic and Metabolomic Analysis of Toxic Dose-Response
Experiments, IEEE Computational Systems Bioinformatics Conference, Stanford
University, CA 8/8/2005 - 8/11/2005
(Poster).
D.A. Mahle, N.J. DelRaso, S.C. Gustafson, C. L.
Leakeas, M.P. Westrick, A.E. Neuforth and N.V. Reo, Comparison of Plasma and
Urine Samples from ANIT-Exposed F344 Rats Using NMR Spectroscopy, Society of
Toxicology Annual Meeting, New Orleans, LA
3/6/2005 - 3/10/2005 (Poster).
D.A. Mahle, N.J. DelRaso, S.C. Gustafson, C.L. Leakeas, M. P. Westrick, A.E.
Neuforth and N. V. Reo, Comparison of Plasma and Urine Samples from ANIT-Exposed
F344 Rats using NMR Spectroscopy, Issues and Applications in Toxicology Risk
Assessment, Fairborn, OH 4/25/2005 -
4/28/2005 (Poster).
Invited Lectures/Presentations
Dr. Alter
Prediction of Protein Structure, Form DNA to
Molecular Machines, Biological Sciences, Ohio
Northern, 11/2/2005.
The Computer Revolution in Biomedical Sciences, Café Scientifique, Montgomery
County Park District, Cox Arboretum, Dayton,
OH, 4/28/2005.
Dr. Berberich
Assessing How Cellular Localization Impacts MdmX Regulation
of the p53 Pathway., 3rd International Mdm2 workshop, Konstanz,
Germany,
9/9/2005 - 9/12/2005.
Understanding How MdmX Deregulation Impacts the p53 Pathway, Case Western Minisymposium
on Cancer, Cleveland, OH, 5/23/2005 - 5/24/2005.
Dr. Leffak
Cis- and Trans-acting Factors at the Human c-myc
Replication Origin, Dept. of Pharmacology & Toxicology, WSU, WSU, Dayton, OH, 5/4/2005.
Scientific Research Ethics, OVALS 3rd Annual
Conference, Dayton, OH, 3/7/2005 - 3/8/2005.
Dr. Organisciak
Age Related Vision Loss, Cafe Scientifique,
Montgomery County Park District, Cox Arboretum, Dayton, OH, 6/23/3005 .
Protection Against Light-Induced Retinal
Degeneration, College of Optometry,
Ohio State University, Columbus,
OH, 7/19/2005.
Dr. Paliy
Cellular Dynamics and Engineering: Cell-Like
Entities Project. Signal Transduction Module., AIBS Review workshop, WP-AFRL, Dayton, OH,
WP-AFRL, 8/16/2005.
Dr. Patrick
Biochemical Processing of Cisplatin-DNA Interstrand
Cross-links (ICLs), Methodist Research Institute, Indianapolis, IN, 3/23/2005.
Biochemical Processing of Cisplatin-DNA Interstrand
Cross-links (ICLs), Wake Forest University,
Winston-Salem,
NC, 4/25/2005 - 4/26/2005.
Biochemical Processing of Cisplatin-DNA Interstrand
Cross-links (ICLs), Temple University Hospital,
Philadelphia,
PA, 8/23/2005 - 8/24/2005.
Biochemical Processing of Cisplatin-DNA Interstrand Cross-links (ICLs), Bowling
Green State University, Bowling Green, OH, 10/26/2005.
Biochemical Processing of Cisplatin-DNA Interstrand Cross-links (ICLs),
University of Kansas Medical Center,
Kansas City, KS, 12/5/2005 -
12/7/2005.
Biochemical Processing of Cisplatin-DNA Interstrand Cross-links (ICLs), Wright State
University, Dayton, OH, 9/30/2005.
Invitation to Participate in or Chair Symposia
Dr. Alter
Ohio Collaborative
Conference on Bioinformatics (OCCBIO), Reactivity-Based Prediction of a
Multi-domain Protein, Replication Protein A, 6/27/2006 - 6/28/2006, Athens OH.
(Session Chair)
Dr. Organisciak
ARVO Ocular Cell and Molecular Biology Symposium,
Protection Against Light Induced Retinal Degeneration, 9/7/2005 - 9/10/2005, Sarasota, FL. (Invited
Participant)
Ohio Lions Research Symposium, Antioxidant
Mediated Gene Expression in Retinal Light Damage, 10/3/2004, Columbus, OH.
(Invited Participant)
Dr. Paliy
CLE Workshop, N/A, 10/12/2005 - 10/13/2005, Dayton, OH, USA. (Invited Participant)
Dr. Prochaska
Bioenergetics and Oxidative Phosphorylation,
2/16/2005 - 2/21/2005, Biophysical Society 2005 Annual Meeting, Long Beach, CA. (Session
Chair)
Symposium on Membrane Proteins, Biological
Membranes, Ohio Center for Technology and Science (OCTS) Columbus, OH, October
8, 2005., On the Reconstitution of Bacterial and Mitochondrial Cytochrome c
Oxidases into Phospholipid Vesicles: Biophysical and Biochemical Properties.,
10/8/2005 - 10/11/2005, Columbus, OH. (Invited Participant)
Member of Editorial Board
Dr. Organisciak
Current Eye Research (1)
Investigative Ophthalmology and Visual Science
Review of Grant Proposals/ Study Section Member/ Ad Hoc
Dr. Alter
National Science Foundation (Ad Hoc)
Dr. Berberich
International Research Foundation (Ad Hoc)
Mersey Kidney
Research (Ad Hoc)
National Cancer Institute (NIH) Cancer Molecular
Pathobiology Study Section (Ad Hoc)
Dr. Leffak
Israel
Cancer Research Foundation (Ad Hoc)
NIH (Member)
Dr. Organisciak
Foundation for Research in Medicine (France) (Ad
Hoc)
International Retina Research Foundation (USA) (Ad Hoc)
Dr. Paietta
National Science Foundation (Ad Hoc)
Research Corporation (Ad Hoc)
Dr. Prochaska
American Chemical Society-Petroleum Research Fund
(Ad Hoc)
American Heart Association Ohio Valley/Southern
Affiliate (Ad Hoc)
American Heart Association Ohio Valley-Southern
Consortium, (Chair, Peer Review Study Section on Molecular Biology)
Dr. Reo
American Heart Association/Southern and Ohio Valley,
Immunology & Microbiology Study Group I (Ad Hoc)
Distinguished Memberships/Titles
Offices Held in National/Professional Organizations
Dr. Berberich
Sigma Xi: WSU Chapter (Vice President)
Dr. Kadakia
Associate member in the American Association of
Cancer Researchers
Committee member of the Miami Valley Association for
Women in Science
Dr. Organisciak
Academy of Medicine Board of Trustees (1998-2008) 2nd
term
Board of Governors Ohio BRTT project on Age Related
Macular Degeneration appointed (2005-2008)
Board of Trustees Sinclair Community College
Biotechnology Program (2003-)
Trustee Biochemistry and Molecular Biology,
Association for Research in Vision and Ophthalmology (ARVO) elected 2002-2007
Dr. Prochaska
Board of Directors, American Heart Association,
Miami Valley, Dayton
Secretary/Treasurer Sigma Xi- WSU Chapter
Treasurer of Bioenergetics subgroup of the
Biophysical Society-elected position
Consultantships
Dr. Alter
Intrexon Corp., Roanoke, VA
Dr. Paliy
Givaudan, Cincinnati, OH
Special Events/ Departmental Seminar Series
Winter Quarter 2005:
Dr. Stephanie Smith, Department of Biological Sciences,
Wright State University
Dr. Courtney Sulentic, Department of Pharmacology
and Toxicology, Wright State University
Dr. Peter Lauf, Cell Biophysics Group, Department of
Pathology,Wright State University, School of Medicine
Dr. Karen Vasques, Department of Carcinogenesis, The
University of Texas M.D. Anderson Cancer Center
Dr. Swati Palit Deb, Department of Biochemistry,
Virginia Commonwealth University
Dr. Maik Huttemann, Department of Molecular Medicine
& Genetics,Wayne State University
Dr. John Bissler, Department of Pediatrics, University of Cincinnati
Dr. Robert Lahue , Eppley Institute for Research in
Cancer, University of Nebraska Medical Center
Spring Quarter 2005:
Dr. Leslie Kuhn, Department of Biochemistry and
Molecular Biology, Michigan State University
Dr. Robert
Hickey, Cancer Center,
Indiana University-Purdue
Dr. Edward Lesnefsky, Department of Medicine, Case Western Reserve
University
Dr. Graham Walker, Department of Biology,
Massachusetts Institute of Technology
Dr. Malgorzata Rozanowska, Cardiff University, UK,
(Sponsored by Department of Neuroscience, Cell Biology, and Physiology and Department
of Biochemistry and MolecularBiology)
Dr. Bill Bonner, Laboratory of Molecular
Pharmacology, Center for Cancer Research NIH
Dr. Barry Winkler, Department of Biomedical
Sciences, Oakland University
Dr. Malin Young, Biosystems Research, Sandia
National Laboratories
Fall Quarter 2005:
Dr. Steven Patrick, Department of Biochemistry and
Molecular Biology, Wright State University
Dr. Alex Almasan, Department of Cancer Biology,
Lerner Research Institute
Dr. David Plas, Department of Genome Science, Genome
Research Inst, University of Cincinnati
Dr. Lawrence Prochaska, Department of Biochemistry
and Molecular Biology, Wright State University
Dr. Lindsey Mayo, Departments of Radiation Oncology
and Pharmacology, Case Western University
Dr. Kathleen Boesze Battaglia, School of Dental
Medicine, University of Pennsylvania
Dr. Christopher Pearson, Hospital for Sick Children,Toronto, Ontario, Canada
Varandani Memorial Lecture (April 7, 2005) Guest
Lecturer: Dr. Paul C. Lauterbur, Department of Chemistry, University of Illinois
at Urbana Champaign
Dr. Leffak received the BMS Mentoring Award at the
BMS 25 Year Reunion October 28th and 29th.
Dr. Alter participated in Café Scientifique at the
Cox Arboretum with the Montgomery County Park District, “The Computer
Revolution in Biomedical Sciences”, 11/2/05.
Dr. Organisciak participated in Café Scientifique at
the Cox Arboretum with the Montgomery County Park District, “Age Related Vision
Loss”, 6/23/06.
Graduate Students Who Graduated in 2005
Dr. Leffak
D.J. Vaz, M.S., Thesis Title: “DNA Replication
Origin promoting activity of CREB transcription factor proteins”. Interviewing
for commercial biotech positions in/near Boston.
Dr. Turchi
Jiazhen Wang, M.S., Thesis Title: Analysis of
Protein Expression in Cisplatin-Resistant Ovarian Cancers by Mass Spectrometry
