Anatomy and Physiology

Refereed publications and book chapters published

van Zundert B, Alvarez FJ, Tapia JC, Yeh HH, Díaz E, Aguayo LG (2004) Developmental-Dependent Action of Microtubule Depolymerization on the Function and Structure of Synaptic Glycine Receptor Clusters in Spinal Neurons. J. Neurophysiol. 91: 1036-1094.

Alvarez FJ, Villalba RM, Zerda R, Schneider SP (2004) Vesicular glutamate transporters in the spinal cord with special reference to sensory primary afferent synapses. J. Comp. Neurol. 472: 259-282.

Sapir T, Geiman EJ, Wang Z, Velasquez T, Frank E, Alvarez FJ, Goulding M (2004) Pax6 and En1 Regulate Two Critical Aspects of Renshaw Cell Development. J. Neurosci. 24: 1255-1264.

González-Forero D, Pastor AM, Delgado-Garcia JM, De la Cruz RR, Alvarez FJ (2004) Synaptic structural modification following changes in activity induced by tetanus neurotoxin in abducens neurons. J. Comp. Neurol. 471: 201-218.

Aguayo LG, van Zundert B, Tapia JC, Carrasco MA, Alvarez FJ (2004) Changes on the properties of glycine receptors during neuronal development. Brain Res. Reviews 47: 33-45.

Gomez-Cambronero, J. Frye, T. and Baumann, M.A. (2004) Ribosomal p70S6K basal activity increases upon induction of differentiation of myelomonocytic leukemic cell lines HL60, AML14 and MPD. Leukemia Res. 28, 755-762.

Baumann, M.A., Frye, T., Naqvi, T. and Gomez-Cambronero, J. (accepted in 2004) Normal neutrophil maturation is associated with selective loss of MAP kinase activation. Leukemia Res. 29, 73-78.

Caserta TM, Knisley AA, Tan FK, Arnett FC and Brown TL. Genotypic Analysis of the TGF beta -509 Allele in Patients with Systemic Lupus Erythematosus and Sjögren’s Syndrome, Annales de Genetique (2004) 47:359-363

Brown, TL. Steroid Hormones, Encyclopedia of Genetics, Revised Ed., (Ed. B. Ness) Salem Press, (2004)

Brown, TL. Sjogren’s syndrome. Magill’s Medical Guide, 3rd Ed. (T. Irons-George Ed.), Salem Press, (2004)

Brown, TL. Placenta. Magill’s Medical Guide, 3rd Ed. (T. Irons-George Ed.), Salem Press, (2004)

Brown TL. Q-VD-OPh, A next generation caspase inhibitor. Cell Volume and Signaling: Proceedings of the Dayton International Symposium. Ed. PK. Lauf. And NC Adragna (2004) Kluwer/Plenum Publishing.

Reedy MA, Selesniemi KL, Smith AN, Gultice A, Brown TL. TGFb Induces Placental Differentiation. Cell Volume and Signaling: Proceedings of the Dayton International Symposium. Ed. PK. Lauf. And NC Adragna (2004) Kluwer/Plenum Publishing.

Dean, J.B., Mulkey, D.K., Henderson III, R.A., Potter, S.J., and Putnam, R.W. (2004) Hyperoxia, Reactive O2 Species, and Hyperventilation: O2-Sensitivity of Brain Stem Neurons, J. Appl. Physiol. 96(2): 784-791.

Mulkey, D.K., Henderson III, R.A., Putnam, R.W., and Dean, J.B. (2004) Oxidative stress decreases intracellular pH, Na+/H+ exchange and increases excitability of solitary complex neurons from rat brain slices, Am. J. Physiol. Cell Physiol. 286: C940 - 951.

Mulkey, D.K., Henderson III, R.A., Ritucci, N.A., Putnam, R.W., and Dean, J.B. (2004) Chemical oxidants acidify solitary complex (SC) neurons in rat. Undersea and Hyperbaric Medicine, 31(1): 107-111.

Muennich EA, Fyffe RE (2004) Focal aggregation of voltage-gated, Kv2.1 subunit-containing, potassium channels at synaptic sites in rat spinal motoneurones. J Physiol 554: 673-685

Leao RN, Oleskevich S, Sun H, Bautista M, Fyffe RE, Walmsley B (2004) Differences in glycinergic mIPSCsin the auditory brain stem of normal and congenitally deaf neonatal mice. J Neurophysiol 91: 1006-1012

Deng Z, Fyffe RE (2004) Expression of P2X7 receptor immunoreactivity in distinct subsets of synaptic terminals in the ventral horn of rat lumbar spinal cord. Brain Res 1020: 53-61

Wang L, Fyffe RE, Lu L (2004) Identification of a Kv3.4 channel in corneal epithelial cells. Invest Ophthalmol Vis Sci 45: 1796-803

Halm D, Secretory control of basolateral membrane K+ and Cl channels in colonic crypt cells. Cell Volume Regulation and Signal Transduction Symposium. P. Lauf and N. Adragna, eds. (Kluwer Academic/Plenum Publishers: New York) p. 117-126, 2004.

Jay B. Dean, Daniel K. Mulkey, Richard A. Henderson III, Stephanie J. Potter, and Robert W. Putnam. Hyperoxia, reactive oxygen species, and hyperventilation: oxygen sensitivity of brain stem neurons. J Appl Physiol 96: 784 – 791, 2004.

D.K. Mulkey, R.A. Henderson III, N.A. Ritucci, R.W. Putnam, and J.B. Dean. Chemical oxidants acidify solitary complex (SC) neurons in the rat. UHM 31, No.1, 2004

Daniel K. Mulkey, Richard A. Henderson III, Nick A. Ritucci, Robert W. Putnam, and Jay B. Dean. Oxidative stress decreases pHi and Na+/H+ exchange and increases excitability of solitary complex neurons from rat brain slices. AJP-Cell Physiol, 286(4), C940-51, April 2004, www.ajpcell.org

Nieder, G.L., F. Nagy and L.A. Wagner. Preserving and sharing examples of anatomical variation and developmental anomaliesvia photorealistic virtual reality. Anatomical Record – New Anatomist 276B:15-18, 2004

Mulkey, D.K., R.A. Henderson III, N.A. Ritucci, R.W. Putnam and J.B. Dean. 2004. Chemical oxidants acidify solitary complex (SC) neurons in the rat. Undersea and Hyperbaric Medicine 31(1): 107-111.

Merriman, H.L., C.A. Hegyi, C.R. Albright-Overton, J. Carlos, Jr., R.W. Putnam and J.A. Mulcare. 2004. A comparison of four electrical stimulation types on Staphylococcus aureus growth in vitro. J. Rehabil. Res. & Develop. 41(2): 139-146.

Mulkey, D.K., R.A. Henderson III, N.A. Ritucci, R.W. Putnam and J.B. Dean. 2004. Oxidative stress decreases intracellular pH and Na+/H+ exchange and increases excitability of solitary complex (SC) neurons from rat brain slices. Amer. J. Physiol. Cell Physiol. 286: C940-C951.

Dean, J.B., D.K. Mulkey, R.A. Henderson III, S.J. Potter and R.W. Putnam. 2004. Hyperoxia, reactive oxygen species, and hyperventilation: oxygen sensitivity of brain stem neurons. J. Appl. Physiol. 96: 784-791.

Putnam, R.W., J.A. Filosa and N.A. Ritucci. 2004. Cellular mechanisms involved in CO2 and acid signaling in chemosensitive neurons. Amer. J. Physiol. Cell Physiol. 287: C1493-C1526.

Taylor, R.J., Schols, D., & Wooley, D.P. (2004). Restricted Entry of R5 HIV Type 1 Strains into Eosinophilic Cells. AIDS Res. Hum. Retrov. 20(11):1244-1253.

Huang, K.J. & Wooley, D.P. (2005*). A new cell-based assay for measuring the forward mutation rate of HIV-1.J. Virol. Methods 124:95-104.
     *Note: Online Publication Date was December 28, 2004; print version available March 2005.

Presentations and invited talks

Alvarez FJ, “Last order interneurons that derive from the V1 metatype” Research Symposium, “Gentaic and moelcaulr approaches to investigate spinal cord circuitry.” Physiological Society. University of Glasgow. March 2004.

Alvarez FJ, “Phenotypic development of Ia inhibitory interneurons and Renshaw cells in the postnatal spinal cord.” Queen Mary University of London. St. Bartholomew's and the Royal London School of Medicine and Dentistry. Department of Neurosciences. March 2004.

Brown TL , Cleveland State University, Dept. of Biological, Geological, and Environmental Sciences, Cleveland, Ohio. “Apoptosis and Autoimmunity: Synthesis, Spectrins, and Sjogren’s Syndrome”

Brown TL, Lake Cumberland Biological Transport Annual Meeting, Cumberland, Kentucky. “Lineage Analysis and Differentiation of Placental Trophoblast Stem Cells”

Brown TL, Department of Family Medicine, Wright State University School of Medicine, Dayton, Ohio “Beta II Spectrin as a Simple Diagnostic Indicator of Sjögren’s syndrome.”

Gomez-Cambronero, J. " Leukocyte cell signaling: chemotaxis and its inhibition" Fellows Forum for Internal Medicine (Cardiology and Hematology/Oncology); VA Medical Center, Dayton, OH; 2004.

Garcia III, A.J., Henderson III, R.A., Putnam, R.W., and Dean, J.B. (2004) Hyperoxia increases neuronal excitability by affecting membrane properties and excitatory input within the CA1 hippocampus, FASEB Journal, 18(5): A1058 (EB 2004, Washington D.C.)

Potter, S.J., Putnam, R.W., and Dean, J.B. (2004) Decreasing oxygen causes an acidification in neurons from respiratory regions of the medulla, FASEB Journal, 18(5): A1058 (EB 2004, Washington D.C.)

Dean, J.B. (2004) Hyperoxia and respiratory control: interactions between PO2, pH and reactive oxygen species, FASEB Journal, 18(5): A1058 (EB 2004, Washington D.C.); poster & invited lecture

Rattan, A.S., Ritucci, N.A., Dean, J.B., and Putnam, R.W. (2004) Intracellular pH and firing rate response to hypercapnic acidosis in medullary brain slices from rats chronically adapted to hypercapnic conditions. FASEB Journal, 18(5): A1061 (EB 2004, Washington D.C.)

Putnam, R.W., Ritucci, N.A., Conrad, S., Dean, J.B. (2004) The relative chemosensitive response to hypercapnia of brainstem neurons from various chemosensitive regions. FASEB Journal, 18(5): A1062 (EB 2004, Washington D.C.)

Conrad, S., Mulkey, D.K., Ritucci, N.A., Dean, J.B., Putnam, R.W. (2004) Development of chemosensitive neurons in the NTS. FASEB Journal, 18(5): A337 (EB 2004, Washington D.C.)

Dean, J.B. (2004) Never Too High or Too Warm. Remembering an Environmental Physiologist Extraordinaire, Dr. Theo Johannes “Hannes” Benzinger (1905-1999). Featured Luncheon Speaker (and poster presentation, FASEB Journal, 18(5): A1104), American Physiological Society History Committee, annual business meeting (EB 2004, Washington D.C.)

Dean, J.B. (2004) NAVSEA Deep Submergence Biomedical Development and Office of Naval Research Undersea Medicine Progress Review—Cellular mechanisms of oxygen toxicity in the mammalian central nervous system, Baltimore, MD.

Fyffe RE, University of Wisconsin-Madison, Department of Physiology. “Ion Channel Expression in Relation to Neuron and Circuit Properties” April 2004

Fyffe RE, Symposium on Active Dendrites in Motor Neurons. University of Colorado, Boulder “Kv2.1 ion channel expression in motoneurons: relation to specific synaptic sites” June 2004

Fyffe RE, Ohio Miami Valley Chapter of Society for Neuroscience Annual Meeting, University of Cincinnati “Overview of Neuroscience Research at WSU” May 2004

Halm D, April 17-21, 2004, Experimental Biology Meeting, Washington, D.C., Selective reduction of Cl and K+ secretion by K+ channel inhibitors in distal colonic mucosa of guinea pig and rat. (poster presentation)

Halm D, May 14, 2004, Department of Biochemistry and Molecular Biology, Wright State University, Secretory Regulation of K+ and Cl channels in colonic crypt epithelial cells. (oral presentation)

Halm D, June 13-16, 2004, Lake Cumberland Biological Transport Group Meeting, K+ channel localization in the colonic epithleium. (oral presentation)

Halm D, September 8-12, 2004, Lipid Signaling in Physiology, Annual Meeting of the Society of General Physiologists, Woods Hole, MA, Lipid-signaling pathways stimulate and inhibit Cl and K+ secretion across guinea pig distal colonic mucosa. (poster presentation)

Halm D, October 19, 2004, Research Forum, Wright State University, Dayton, OH, Selective reduction of Cl and K+secretion by K+channel inhibitors in distal colonic mucosa of guinea pig and rat; and Lipid-signaling pathways stimulate and inhibit Cl and K+ secretion across guinea pig distal colonic mucosa. (poster presentations)

Halm D, November 12, 2004, Ohio Physiological Society, Cincinnati, OH, Selective reduction of Cl and K+secretion by K+channel inhibitors in distal colonic mucosa of guinea pig and rat. (poster presentation)

Henderson R, Introduction to Featured Topic: Oxygen Sensing by Neural Tissues, invited presentation to American Physiological Society session at Experimental Biology 2004

Nieder, G.L., Invited Seminar: Photorealistic Virtual Anatomy: Preserving and Sharing Anatomical Specimens; The Ohio State University, Department of Anatomy, Columbus, OH, 2004

Poster Presentation: Nieder, G.L., L. A. Wagner and F. Nagy. The QuickTime VR Anatomical Resource: A library of shared photorealistic virtual specimens. American Association of Clinical Anatomy Meeting, Moraga, CA.

Invitation to Chair Symposia

Brown TL, Chair Emeritus, Lake Cumberland Biological Transport Meeting, Cumberland, KY, 2004

Gomez-Cambronero, J. Miller, M., DiFulvio, M. and Lehman N. (2004). Hyperphosphorylation of the phospholipase D2 (PLD2) isozyme in Stable COS-7 and HL-60 Cells Expressing the Neutrophilic Phenotype. 37th National Meeting of the Society for Leukocyte Biology. Toronto, Canada. (conflicting date with NIH study section)

Dean, J.B. (2004), Chair, Featured Topic Symposium, Experimental Biology 2004, Oxygen Sensing by Neural Tissues (APS Respiratory Section)

Fyffe RE, Ohio Miami Valley Neuroscience Day, University of Cincinnati, Genome Research Institute, May 2004.

Granting Agency Study Section Memberships

Alvarez FJ, Ad hoc grant reviewer for the Conseil Scientifique of “Association Francaise contre les Myophathies” (Paris, France)

Alvarez FJ, Ad hoc grant reviewers from National Science Foundation, Reviewer Panelist for Developmental Neuroscience Programs

Bigley N., grant reviewer for the Alzheimer’s Association.

Bigley N., participated in community outreach as Director of the Science Apprenticeship Program (SAP) for 18 area high school students.

Cambronero J, Panel Reviewer, Wright State University-SOM (Research Challenge) Fall, 2004

Cambronero J, NIH Panel reviewer for Erythrocyte and Leukocyte Biology (ELB) Study Section, 2004

Cambronero J, NIH Panel reviewer for Cell Development and Function (CDF-2) Study Section, 2004

Dean, J.B., National Institutes of Health, Respiratory and Integrative Biology and Translational Research (RIBT)

Fyffe RE, Advisory Board, Center of Biomedical Research Excellence (COBRE), University of North Dakota. Site Visit/Symposium presentation, June 9-11, 2004

Halm D, NIH-NIDDK Special Emphasis Panel, Regulation of Intestinal Transport and Mechanisms of Intestinal-Microbial Interactions, reviewer, April 7, 2004

Halm D, NIH-NIDCR Special Emphasis Panel, Specialized Centers for Oral, Dental and Cranofacial Research, reviewer, June 21, 2004

Editorial Board Member

Brown TL, Biology of Reproduction

Cambronero J, Ad hoc reviewer for: J. Leukocyte Biology, Am. J. Hematology, J Biol. Chem.

Dean, J.B., Undersea and Hyperbaric Medicine

Dean, J.B., Journal of Applied Physiology

Fyffe RE, Review manuscripts (n=9) for Journal of Comparative Neurology, Brain Research, Journal of Neurophysiology and Neuroscience.

Halm D, Editorial board, American Journal of Physiology: Cell Physiology (1999-2005)

Putnam R, American Journal of Physiology: Cell Physiology (Editorial Board from 1990 - present)

Offices held in National professional organizations

Dean, J.B., Member, History Publications Advisory Committee, The American Physiological Society.

Fyffe RE, President 2004-2005, Miami Valley Chapter of Society for Neuroscience

Henderson R, Member, Annual Meeting Program Activity Planning Committee, Society of Free Radical Biology and Medicine (formerly Oxygen Society). Director of CME

Mechlin KT, Board of Directors of the Central Association of Advisors for Health

Mechlin KT, Professions (elected for three year term from 2004-2007)

Mechlin KT, Serve on Ad-Hoc Ethics Committee for National Association of Advisors for Health Professions

Symposia Organized

11th Annual Wright State University Molecular Biology Retreat. Wright State University, Dayton, OH.

Fyffe RE, Central Research Forum, Wright State University, October 19, 2004 Ohio Miami Valley Chapter, Society for Neuroscience, Mini-Symposium, Wright State University, December 3, 2004

Fyffe RE, Cell Dynamics and Engineering Center of Excellence Opening Ceremony, Wright State University, November 5, 2004.

Local, national, or international awards given to the faculty member and staff or students

Awards to Faculty

The prestigious " Sembrador" Award, that symbolizes the sowing of knowledge among one's disciples, was presented to Dr. Julian Gomez-Cambronero, Professor of Physiology and Biophysics at Wright State University, Dayton, OH, has been awarded the prestigious " Sembrador" Award by his hometown in Spain, Manzanares, a city in Castilla-La Mancha, the land of don Quijote. The award was presented at the Winter Courtyard of the 13th century Castle " Pilas Bonas" of the Order of Calatrava. The Award was originally established in 1985 by the city's news magazine " Siembra" , to be given annually to those men and women born on, or associated with, the city of Manzanares, who have demonstrated the highest achievements in the arts, humanities or the learned professions and whose accomplishments have transcended beyond the local frontiers, nationally or internationally. In the words of the Journal's director, Ms. Isabel Romera, " Dr. Gomez-Cambronero is being recognized for his outstanding academic merits and his leadership in inflammatory and leukemia biomedical research in the U.S. He is the first scientist in our city to receive the award that is traditionally given to orchestra composers, choral directors, poets, playwrights, historians, painters, sculptors and doctors. He has proudly taken the name of our city far beyond Manzanares and across the Atlantic Ocean" .

Pearson J, School of Medicine Mentor Award

Awards to students

Student (Isabel Campos) Travel award for national meeting presentation at Experimental Biology Meeting: Campos, I., Di Fulvio, M. and Gomez-Cambronero, J. (2004) Screening of PLD2 expressed exons in human neutrophils by RT-PCR. Experimental Biology. Washington, DC

Mr. Alfredo J. Garcia III (BMS doctoral student), Porter Physiology Development Award, for minority students who are engaged in graduate study in physiology Mr. Alfredo J. Garcia III (BMS doctoral student), Outstanding Poster Presentation by a Graduate Student, Miami Valley Chapter, Society for Neuroscience, Cincinnati, OH

PhD student, Alfred J. Garcia is recipient of the American Physiological Society’s Porter Predoctoral Fellowship, 2004. He also received a Poster Award from the Ohio Miami Valley Society for Neuroscience, (2004) Cincinnati, OH.

Outreach programs

Cambronero J, Panel Reviewer, Wright State University-SOM (Research Challenge) Fall, 2004

Cambronero J, NIH Panel reviewer for Erythrocyte and Leukocyte Biology (ELB) Study Section, 2004

Cambronero J, NIH Panel reviewer for Cell Development and Function (CDF-2) Study Section, 2004

Cambronero J, Panel Reviewer, Wright State University-SOM (Research Challenge) Fall, 2004

Cambronero J, NIH Panel reviewer for Erythrocyte and Leukocyte Biology (ELB) Study Section, 2004

Cambronero J, NIH Panel reviewer for Cell Development and Function (CDF-2) Study Section, 2004

Cambronero J, guided a postdoc in lab to write a grant proposal for the AHA that was submitted in Jan 2005

Cambronero J, wrote consultant letter for Dr. Dan Halm's grant proposals to the NIH

Fyffe RE, Career Mentorship Program – Darke County Educational Service Center July 2004

Fyffe RE, Centerville High School – Gross Anatomy and Neuroscience May 2004

Fyffe RE, Health and Wellness Day, Driscoll Elementary – April 2004

Fyffe RE, Miami Valley School – teacher and student visit, Dec 2004

Fyffe RE, Driscoll Elementary School – project mentor, 5th grade Exploravision (team received honorable mention at national level)

Fyffe RE, Various local and regional newspaper interviews and quotations (human genome project, spinal cord injury, stem cells, Christopher Reeve, WBI, BRTT project funding etc)

Fyffe RE, Local TV interviews (Channel 7; Channel 22; Christopher Reeve and spinal cord research)

Henderson R, Member, Xenia Township Water Source Protection Committee

Wooley D, Participated in Science Apprenticeship Program (SAP), headed by Nancy Bigley.

Study section memberships

Henderson R, Ad hoc reviewer, NIH Oral, Dental and Craniofacial Sciences Study Section

Henderson R, Ad hoc reviewer, American Institute of Biological Sciences

Off campus or special interest courses

Putnam R, National Institutes of Health, Chair, Program Project Grant Special Emphasis Panel (NICHD) (2004)

Putnam R, National Institutes of Health Special Emphasis Panel to review National Research Service Awards, Bethesda, MD (2004)

Putnam R, National Institutes of Health, Chair, Program Project Grant Special Emphasis Panel (NICHD) (2004)

Special event

Henderson R, APS Featured Topic at Experimental Biology 2004: “Oxygen sensing by neural tissues,” by Environmental and Hyperbaric Cell Biology Facility, Jay Dean lead.