Biochemistry & Molecular Biology

Dr. Steven J. Berberich

M. Ghosh, K. Huang and S.J. Berberich, 'Overexpression of Mdm2 and MdmX   fusion proteins alters p53 mediated transactivation, ubiquitination and degradation," Biochemistry, 2003,42(8):2291-2299

Dr .Patrick R. Dennis

A. Jaeschke, P.B. Dennis, and G. Thomas, "mTOR: A mediator of intracellular homeostasis," Target of Rapamycin, Current Topics in Microbiology and Immunology, 279, pp. 283-298, 2003, Published by Springer.

Dr. Darrell E. Fleischman

D. E. Fleischman, "Stem Nodulating Bacteria in Legumes," Biotechnology of Biofertilizers (S. Kannaiyan, ed.) Narosa Publishing House, New Delhi, pp. 179-192, 2003.

Dr. Michael Leffak

G. Liu, M. Malott, and M. Leffak, "Multiple Functional Elements Comprise a Mammalian Replicator," Molecular and Cellular Biology, 23, 1832-1842, 2003.

V. Potaman, J. Bissler, V. Hashem, E. Oussatcheva, L. Lu, L. Shlyakhtenko, Y. Lyubchenko, T. Matsuura, T. Ashizawa, M. Leffak, C. Benham and R. Sinden, "Unwound structures in SCA10 (ATTCT) (AGAAT)n repeats," Journal of Molecular Biology, 326, 1085-1111, 2003.

Dr. Daniel T. Organisciak

D.T. Organisciak, R.M. Darrow, and L.S. Barsalou, "Light-Induced Retinal Degeneration," Ocular Neuroprotection, Ed. L.A. Levin., A. DiPolo, Marcel Dekker, NY, pp. 85-107, 2003.

D.T. Organisciak, R.M. Darrow, L. Barsalou, R.K. Kutty and B. Wiggert, "Light Damage Susceptibility in Transgenic Rats Having Rhodopsin Mutations," Invest. Ophthalmol. Vis. Sci, 44, 486-492, 2003.

D. Vaughan, S. Coulibaly, R.M. Darrow and D.T. Organisciak, "Morphological Study of Light Damage Susceptibility in P23H and S334 ter Transgenic Rats," Invest. Ophthalmol. Vis. Sci., 44, 848-855, 2003.

H. Sakaguchi, M. Miyagi, R.M. Darrow, J.S. Crabb, J.G. Hollyfield, D.T. Organisciak and J.W. Crabb, "Intense Light Exposure Changes the Crystallin Content in Retina," Experimental Eye Research, 76, 131-133, 2003.

Dr. Steve M. Patrick

S. M. Patrick, G. Oakley, J. Yao, M. P. Carty, J. J. Turchi, and K. Dixon, "RPA Phosphorylation in Mitosis Alters DNA Binding and Protein-Protein Interactions," Biochemistry, 42, 3255-3264, 2003.

S. Tornaletti, S.M. Patrick, J. J. Turchi, and P. C. Hanawalt, "Behavior of T7 polymerase and mammalian RNA polymerase II at site-specific cisplatin adducts in the template DNA," Journal of Biological Chemistry, 278, 35791-35797, 2003.

Dr. Lawrence J. Prochaska

A. J. Lincoln, N. Donat, G. Palmer, G., and L. Prochaska  , "The Effects of Site-Specific Polyclonal Antibodies Against Conserved Hydrophilic Domains of Bovine Heart Cytochrome c Oxidase Subunit III on the Functioning of the Enzyme," Archives of Biochemistry and Biophysics, 416, 81-91 (2003), 416, 81-91, 2003.

Dr. John J. Turchi

Q. Chai, Zheng,L., M. Zhou,  J.J. Turchi and B. Shen, "Interaction and stimulation of human FEN-1 nuclease activities by heterogeneous nuclear ribonucleoprotein A1 in a-segment processing during Okazaki fragment maturation," Biochemistry, 42, 15045-15052, 2003.

G.G. Oakley, S.M. Patrick, J.Q. Yao, M.P. Carty, J.J. Turchi, and K. Dixon, "RPA phosphorylation in mitosis alters DNA binding and protein- protein interactions," Biochemistry, 42, 3255-3264., 2003.

S. Tornaletti, S.M. Patrick, J.J. Turchi, and P.C. Hanawalt, "Behavior of T7 RNA polymerase and mammalian RNA polymerase II at site-specific cisplatin adducts in the template DNA," Journal of Biological Chemistry, 278, 35791-35797., 2003.

Dr. Gerald M. Alter

G.M. Alter, J. Nuss, and D. Sweeney, Structure Predictions Involving Replication Protein A, International Union of Bichemists, Toronto Canada 8/12/2003 –8/17/2003 (Poster).

G.M. Alter, Bioinformatics and How to Calculate and Protein's Structure, Biochemistry and Molecular Biology Program, Wooster College, Wooster, OH, 11/7/2003.

G.M. Alter, Protein Structure Prediction, Replication Protein A, Hutton Seminar Series, Department of Pediatric Informatics, Children's Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati ,v 9/4/2003.

Dr. Steven J. Berberich & Dr. Madhavi Kadakia

V. Jain, A. Stapleton, M. Kadakia, J. Mantil and S.J. Berberich, Effects of 2-deoxy-D-glucose on gene expression profiling of human gliomas, Oncogenomics 2003, Phoenix, AZ  1/29/2003 - 2/3/2003 (Poster).

Dr . Steven J. Berberich

S.J. Berberich, Cancer Research Initiatives, Wright State University, Life Sciences Conference (OVALS), University of Cincinnati, 3/10/2003 - 3/11/2003.

S.J. Berberich, Effects of 2-deoxy-glucose on gene expression in human gliomas, Department of Physiology and Biophysics, Wright State University, 2/6/2003.

S.J. Berberich, Gene Expression Profiling of Glioblastomas exposed to 2-deoxy-glucose, University of Louisville, James Brown Cancer Center, Louisville, KY 7/23/2004 – 7/24/2004.

S.J. Berberich, Gene Expression Profiling of Human Tumor Cells, University of Dayton, Biology Department, University of Dayton, Biology Department, Dayton, OH,3/13/2003.

S.J. Berberich, Regulation of ARF-dependent Mdm2 sumolyation by MdmX, Second International Mdm2 conference, Washington DC, 10/18/2003 - 10/20/2003.

Dr. Ina R. Bicknell

N.V. Reo, I.R. Bicknell, L. Prochaska, A. Neuforth, S. Shah, L. Shroyer, and D. Moyer, Effects of Low-dose Chronic Exposure to Persian Gulf War Chemicalsand Stress on Rat Brainstem Function and Energy Metabolism, International Society for Magnetic Resonance in Medicine, 11th Annual Meeting, Ontario, Canada  7/7/2003 - 7/10/2003 (Poster).

I.R. Bicknell, R.M. Darrow, and D.T. Organisciak, Evaluation of Hearing in the P23H Rat Model of Retinitis Pigmentosa, Association for Research in Vision and Ophthalmology Annual Meeting, Fort Lauderdale, FLA  5/4/2003 –5/9/2003 (Poster).

Dr. Darrell E. Fleischman

I. Forquer, D.M. Kramer and D. Fleischman, Properties of Photosynthetic Reaction Ceters Purified from Bradyrhizobium strain BTAi1, 12th Western Photosynthesis Conference, Asilomar, California  1/3/2003 (Poster).

D. Fleischman, Rhizobia that have Photosynthetic Systems, Department of Biochemistry and Molecular Biology,Wright State University, Dayton, OH, 5/9/2003.

Dr. Madhavi Kadakia

V. Jain, A. Stapelton, M. Kadakia, J. Mantil, and S.J. Berberich, Effect of 2-deoxy-D-glucose on gene expression profiling of human gliomas, Oncogemonics 2003. Dissecting Cancer Through Genome Research, Phoenix, AZ 1/29/2003 – 2/3/2003 (Poster).

Dr. Michael Leffak

M. Ghosh, M. Ritzi, A. Schepers, and M. Leffak, Replication protein distribution at the c-myc replicator, Eucaryotic DNA Replication, Cold Spring Harbor 9/3/2003 - 9/7/2003 (Poster).

M. Kemp, M. Ghosh, G. Liu, and M. Leffak, The histone deacetylase inhibitor trichostatin A modulates replication origin activity in human cells, Eucaryotic DNA Replication, Cold Spring Harbor 9/3/2003 - 9/7/2003 (Poster).

J. Casper, M. Kemp, M. Ghosh, G. Randall, G. Liu, and M. Leffak, The c-myc DNA Unwinding Element Binding Protein DUE-B Modulates DNA Replication, Eucaryotic DNA Replication, Cold Spring Harbor  9/3/2003 –9/7/2003 (Platform).

Dr. Daniel T. Organisciak

I. Bicknell, R.M. Darrow, D.T. Organisciak, Evaluation of Hearing in the P23H Rat Model of Retinitis Pigmentosa, The Association for Research in Visions and Ophthalmology, Fort Lauderdale, FL  5/2/2003 - 5/9/2003 (Poster).

D.T. Organisciak, L.S. Barsalou, K.M. Henkels, R.M. Darrow, Circadian Gene Expression Profiles in Rat Retina: What are the Crystallins Doing?, The Association for Research in Visions and Ophthalmology, Fort Lauderdale, FL  5/2/2003 - 5/9/2003 (Poster).

R. Grewal, D.T. Organisciak, R. Darrow, L. Barsalou, P. Wong, Micro - Array Analysis of Gene Expression in Light - Induced Retinal Degeneration Susceptibility, The Association for Research in Visions and Ophthalmology, Fort Lauderdale, FL  5/2/2003 - 5/9/2003 (Poster).

R.M. Kelln, R. Darrow, L. Barsalou, D.T. Organisciak, P. Wong, Characterization of the Rat Rom1 Ortholog as Part of the Molecular Gene Profile of Light – Induced Retinal Degeneration, The Association for Research in Visions and Ophthalmology, Fort Lauderdale, FL  5/2/2003 - 5/9/2003 (Poster).

B.W. Jones, C.B. Watt, D.K. Vaughan, D.T. Organisciak, R.E. Marc, Retinal Remodeling Triggered by Light Damage in the Albino Rat, The Association for Research in Visions and Ophthalmology, Fort Lauderdale, FL  5/2/2003 – 5/9/2003 (Poster).

K. Renganathan, M. Sun, R. Darrow,  L. Shan, X. Gu, R.G. Salomon, S. Hazen, D.T. Organisciak, J.W. Crabb, Light Induced Protein Modifications and Lipid Oxidation Products in Rat Retina, The Association for Research in Visions and Ophthalmology, Fort Lauderdale, FL 5/2/2003 - 5/9/2003 (Poster).

C. Yu, Y. Guo, R.M. Mahdi, S. Ebong, R.M. Darrow, D.T. Organisciak, C.E. Egwuagu, SOCS Proteins have Neuroprotective Role in the Mammalian Retina, The Association for Research in Visions and Ophthalmology, Fort Lauderdale, FL  5/2/2003 - 5/9/2003 (Poster).

K.M. Henkels, S. Siraj, R.M. Darrow, L.S. Barsalou, D.T. Organisciak, Genetic, Age and Light Mediated Effects on Retinal Crystallins, The Seventh Great Lakes Vision Research Conference, Miami University, Oxford, Ohio (Poster).

K.A. West, X. Gu, K. Renganathan, M. Sun, R. Darrow, S. Hazen, R.G. Saloman, D.T. Organisciak, J. Crabb, Light Induced Protein Modifications and Lipid Oxidation Products in Rat Retina, The Seventh Great Lakes Vision Research Conference, Miami University, Oxford, Ohio (Poster).

D.T. Organisciak, Light Induced Retinal Degeneration and Antioxidant Protection, Eye Research Institute Oakland University, Oakland, MI, 7/29/2003 - 7/30/2003.

Dr. Steve M. Patrick

J.J. Turchi and S. M. Patrick, Effect of Phosphorylation on the DNA Binding Activity of Human Replication Protein A (RPA), Eukaryotic DNA Replication, Cold Spring Harbor, NY  9/3/2003 - 9/7/2003 (Platform).

J.J. Turchi and S. M. Patrick, Recognition of Cisplatin-DNA Damage by the Nucleotide Excision Repair Proteins Xeroderma Pigmentosum Group A and Replication Protein A, Platinum Coordination Compounds in Cancer Chemotherapy, New York, NY  10/8/2003 - 10/11/2003 (Platform).

G. G. Oakley, S. M. Patrick, K. Dixon, and J. J. Turchi, Phosphorylation of Replication Protein A (RPA) Induces a Molecular Switch from DNA Replication to DNA Repair, 8th International Workshop on Ataxia Telangiectasia (ATW8), Queensland, Australia  9/10/2003 - 9/14/2003 (Poster).

Dr. Lawrence J. Prochaska

N.R. Reo, I. Bicknell, L. J. Prochaska, A. Neuforth, S Shah, L. Shroyer, and D. Moyer, Effects of Low-Dose Chronic Exposure to Persian Gulf War Chemicals and Stress on Rat Brainstem Function and Energy Metabolism., International Society for Magnetic Resonance in Medicine, Toronto, Canada 7/16/2004 – 7/20/2004 (Poster).

D. Riegler, C. Pokalsky, D. Zavslavsky, R. Gennis, and L. J. Prochaska, The Effects of Alkaline pH on the Steady-State Electron Transfer Activity of Bovine Cytochrome c Oxidase. , Gordon Research Conference on Cellular and Molecular Bioenergetics, Meridan, NH 6/19/2003 - 6/24/2003 (Poster).

Dr. Nicholas V. Reo

B. Hoffman-Kuczynski and N. V. Reo, Effects of Myo-Inositol Treatment on Plasmalogen Levels and Biosynthesis in Rat Brain, International Society of Magnetic Resonance in Medicine, 11th Scientific Meeting, Toronto, Canada  7/12/2003 - 7/17/2003 (Poster).

N. V. Reo, I. Bicknell, L. Prochaska, A. Neuforth, S. Shah, L. Shroyer, D. Moyer, Effects of Low-Dose Chronic Exposure to Persian Gulf War Chemicals and Stress on Rat Brainstem Function and Energy Metabolism, International Society for Magnetic Resonance in Medicine, 11th Scientific Meeting, Toronto, Canada 7/10/2003 - 7/16/2003 (Poster).

B. Hoffman-Kuczynski and N. V. Reo, Studies of Myo-Inositol and Plasmalogen Metabolism in Rat Brain Areas, Neuroscience Symposium, Central Research Forum, Wright State University  11/17/2003 - 11/17/2003 (Poster).

B. Hoffman-Kuczynski and N. V. Reo, Effects of Myo-Inositol Treatment on Plasmalogen Levels and Biosynthesis in Rat Brain, Neuroscience Symposium, Central Research Forum, Wright State University  11/17/2003 - 11/17/2003 (Poster).

Dr. John J. Turchi

B.J. Andrews and J.J. Turchi, Development of a high-throughput screen for inhibitors of RPA and its role innucleotide excision repair., 5th Annual Midwest DNA repair, Rochester MN  5/4/2003 - 5/5/2003 (Poster).

K. Pawelczak, P.B. Dennis and J.J. Turchi , DNA Replication Fork Collapse Signals to the mTOR/S6K Pathway., 5th Annual Midwest DNA repair, Rochester, MN 5/4/2003 - 5/5/2003 (Poster).

J.J. Turchi and S.M. Patrick, Effect of Phosphorylation on the DNA Binding Activity of Human Replication Protein A (RPA)., Eukaryotic DNA replication , Cold Spring Harbor, NY 5/4/2003 - 5/5/2003 (Poster).

K.S. Pawelczak, P.B. Dennis and J.J. Turchi, DNA Replication Fork Collapse Signals to the mTOR/S6K Pathway., Eukaryotic DNA replication, Cold Spring Harbor, NY 5/4/2003 - 5/5/2003 (Poster).

B.J. Andrews and J.J. Turchi, Development of a high-throughput screen for inhibitors of replication protein A and its role in DNA replication, Eukaryotic DNA replication, Cold Spring Harbor, NY 5/4/2003 - 5/5/2003 (Poster).

B.J. Andrews and J.J. Turchi, Development of a high-throughput screen for inhibitors of replication protein A and its role in DNA replication and repair, AACR Molecular targets in Cancer Chemotherapy, Boston, MA 11/17/2003-11/20/2003 (Poster).

J.J. Turchi, Recognition of Cisplatin-DNA Damage by Mammalian DNA Repair Proteins., International Symposium on Platinum and coordination complexes in cancer chemotherapy, NY.NY 10/8/2003-10/11/2003 (Poster).

H.J. Boeckman and J.J. Turchi, Mechanism of cispaltin sensitization of cancer cells to ionizing radiation, 5th Annual Midwest DNA repair conference, Rochester, MN 6/3/2003 (Poster).

G.G. Oakley, S.M. Patrick, K. Dixon and J.J. Turchi, Phosphorylation of RPA induces a molecular switch from DNA replication to DNA repair, 8th international workshop on Ataxia-telangiectasia, Queensland, Australia  9/10/2003 - 9/14/2003 (Poster).

J.J. Turchi, Recognition of Cisplatin-DNA Damage by Mammalian DNA Repair Proteins, ISPCC, NY, NY 10/8/2003-10/11/2003.

D.T. Organisciak, Ohio Lions Research Symposium, Antioxidant Mediated Gene Expression in Retinal       Light Damage, 10/4/2003, Columbus, OH. (Invited Participant)

J.J. Turchi, ISPCC, Recognition of Cisplatin-DNA Damage by Mammalian DNA Repair Proteins., NY, NY. 10/8/2003-10/11/2003 (Session Chair)

D.T. Organisciak, Current Eye Research

               Investigative Ophthalmology and Visual Science

Alter, G.M., National Science Foundation (ad hoc)

Berberich, S.J., Science Foundation (ad hoc)

Berberich, S.J., National Cancer Institute (NIH) Cancer Molecular Pathobiology (member)

Berberich, S.J., WSU-SOM Research committee (member)

Dennis, P., Welcome Trust (ad hoc)

Leffak, M., American Cancer Society - Ohio Affiliate (ad hoc)

Leffak, M., NIH, Biochemistry (member)

Prochaska, L., American Heart Association Ohio Valley/Southern Affiliate (member)

Reo, N.V., International Society for Magnetic Resonance in Medicine (ad hoc)

Turchi, J.J., ACS Ohio Division (member)

Turchi, J.J., U.S. Civilian Research & Development Foundation (ad hoc)

 

Berberich, S.J., Sigma Xi: WSU Chapter (Vice President)

Bicknell,, I.R., Co-coordinator Miami Valley Association for Women in Science

Kadakia, M., Committee member of the Miami Valley Association for Women in Science

Leffak, M., Dayton Heart Hospital, Dayton, OH (Consultantship)

Leffak, M., Replicor Inc., Montreal, CA (Consultantship)

Organisciak, D.T., Trustee Biochemistry and Molecular Biology, Association for Research in Vision and Ophthalmology (ARVO) 2002-2005

Prochaska, L., Board of Directors, American Heart Association, Miami Valley, Dayton

Winter Quarter 2003:

Dr. David Robbins, Department of Molecular Genetics, University of Cincinnati

Dr. Jay Dean, Department of Physiology and Biophysics, Wright State University

Dr. Satish Nair, Department of Biochemistry , University of Illinois at Urbana-Champaign

Dr. Carl Bauer, Department of Biology, Indiana University

Dr. Peter Roach, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine

Dr. Steven Vik, Department of Biological Sciences, Southern Methodist University

Spring Quarter 2003:

Dr. David Cool, Department of Pharmacology and Toxicology, Wright State University

Dr. Edward Pugh, Department of Ophthalmology, University of Pennsylvania School of Medicine

Dr. Rosalie Crouch, Albert Florens Storm Eye Institute, Medical University of South Carolina

Dr. Phillip Sharp, Massachusetts Institute of Technology (Varandani Memorial Lecture)

Dr. Laurence Fechter, Research Service, Jerry Pettis Memorial Veterans Medical Center

Dr. Darrell Fleischman, Department of Biochemistry and Molecular Biology. Wright State University

Dr. Ronald Swanstrom, Center for Aids Research, University of North Carolina at Chapel Hill

Dr. Donald Jacobsen, Department of Cell Biology, Lerner Research Institute

Dr. Jay Pettegrew, Department of Psychiatry, University of Pittsburgh School of Medicine

Fall Quarter 2003:

Dr. Andrew Miranker, Department of Molecular Biophysics & Biochemistry, Yale University

Dr. William Rea, Environmental Health Center, Dallas, Texas

Dr. Bilikere Dwarakanth, INMAS, Delhi, India

Dr. Aart Jochemsen, Department of Molecular and Cell Biology, Leiden University Medical Center The Netherlands

Dr. Ashok Bhagwat, Department of Chemistry, Wayne State University

Dr. Sidney Whiteheart, Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine

Dr. Min-Xin Guan, Division of Human Genetics, Cincinnati Children=s Hospital Medical Center

Dr. Randy Legerski, Department of Molecular Genetics, M.D. Anderson Cancer Center

Dr. Janet Leatherwood, Department of Molecular Genetics and Microbiology, State University of New York

      None.

None.

      None.

      None.

      None.

Mini-Medical School, Drs. Steven Berberich, Mithua Ghosh, Maloy Ghosh, Madhavi Kadakia, and Michael Leffak, Community Relations Scientific Presentation, Wright State University, Dayton, Ohio, Fall 2003 Sept 23, 2003-October 28, 2003

Kelly Jo Huang, Ph.D. (Dr. Dawn Wooley), "Positive Evolutionary Selection and Mutation Rates of HIV-1 CNS-Derived Reverse Transcriptase Variants", Dayton, OH, University of Cincinnati

Alagammai Kalippan, M.S. (Dr. Gerald Alter), "Levels of Detoxifying Enzymes in Chemically Sensitive and Normal Individuals", Wright State University

David Riegler, M.S. (Dr. Lawrence.Prochaska), "The Effects of Alkaline pH on Bovine Cytochrome c Oxidase Activity", Wright State University

Jeffrey Taylor, Ph.D. (Dr. Dawn Wooley), "A Model to Study HIV-1 Infection of Eosinophils", Tennessee, Vanderbilt

Xuan Zhou, M.S. (Dr. John Turchi), "Affinity Chromotography and Proteomic Approach to Determine the Spectrum of Platinum-DNA Binding Proteins from Ovarian Cancer Cell Lines"