WSU Graduate Courses - Biomedical Sciences/BMS

BMS 655 MATRIX ALGEBRA (Credits: 5)

(Also listed as MTH 655.) Matrices, systems of equations, vector spaces, inner products, linear transformations, determinants, eigenvalues, eigenvectors, quadratic forms, and symmetric matrices.

PREREQUISITE: BMS 698.

BMS 664 COMPUTATIONAL STATISTICS (Credits: 4)

(Also listed as STT 664.) Review of the principles underlying statistical methodology and techniques available for analyzing biomedical data. Emphasizes the necessity for careful design of experiments and the structure of data.

PREREQUISITE: STT 560 & STT 561 OR EQUIVALENT.

BMS 668 INTRODUCTION TO SAS (Credits: 2)

Introduces the use of the statistical analysis system (SAS), a statistical computing package widely used in industry, government, and academia.

PREREQUISITE: BMS 666 OR EQUIVALENT.

BMS 674 ADVANCED STAT METHODS (Credits: 1)

Practical, applied coverage of basic statistical principles and terminology, ANOVA, multiple and logistic regression, sample size issues and experimental design. Biomedical data examples, review of computer output and class exercises are provided.

BMS 698 BIOMEDICAL COMPUTER SCIENCE (Credits: 4)

Introduces programs such as SYMVU, CSMP, and ORTEP, which create plotted output. FORTRAN is also introduced. Problems and data used are from the life sciences. Graded pass/unsatisfactory. Enrollment in Biomedical Sciences Ph.D. program required.

BMS 698 BIOMEDICAL COMPUTER SCIENCE LABORATORY (Credits: )

BMS 703 RESEARCH ETHICS (Credits: 1)

(Also listed as BMB 703.) Research ethics emphasizes the evaluation of hypothetical ethical scenarios. Class discussion is based on integrating ethical policy and practices as they relate to research at Wright State. Graded pass/unsatisfactory.

BMS 705 LINEAR SYSTEMS I (Credits: 4)

(Also listed as EE 701 and EGR 701.) Signal representation, orthonormal bases, and generalized Fourier series. Description of linear, discrete, and continuous systems. Systems analysis via classical equations, convolution, and transform methods.

PREREQUISITE: BMS 664 AND 698.

BMS 706 LINEAR SYSTEMS II (Credits: 3)

(Also listed as EE 702.) State variable representations of continuous and discrete systems. Linear vector spaces and similarity transformations; eigen-analysis, time and transform domain solutions of linear state equations; controllability, observability, and stability of linear systems.

PREREQUISITE: BMS 705.

BMS 708 DIGITAL SIGNAL PROCESSING (Credits: 4)

Data Acquisition and Quantization, Unitary Transforms, Circular Convolution, Hilber Transform, FIR/IIR Filter Design and Realization, Analysis of Finite=Precision Numerical Effects, Spectral Estimation Cepstrum Analysis.

PREREQUISITE: BMS 706.

BMS 710 CONTROL SYSTEMS I (Credits: 3)

(Also listed as EE 613.) Provides students with a general control background. Major topics include block diagrams and signal-flow graphs, electromechanical modeling including state variable representation, time response, root locus, and introduction to design.

PREREQUISITE: BMS 664 AND 698. COREQUISITE: BMS 711.

BMS 711 CONTROL SYSTEMS I LABORATORY (Credits: 1)

(Also listed as EE 614.) Applications and testing of control systems theory with electromechanical systems.

PREREQUISITE: BMS 664 AND 698. COREQUISITE: BMS 710.

BMS 712 CONTROL SYSTEMS II (Credits: 3)

(Also listed as EE 615.) Using Control Systems I background, course concentrates on controller design, in both the time and frequency domains, using NYquist, Bode, root locus and state variable techniques. Digital control concepts are introduced.

PREREQUISITE: BMS 710 AND 711. COREQUISITE: BMS 713.

BMS 713 CONTROL SYSTEMS II LABORATORY (Credits: 1)

(Also listed as EE 616.) Application and testing of control systems theory with electromagnetic systems.

PREREQUISITE: BMS 710 AND 711. COREQUISITE: BMS 712.

BMS 725 PHYSICAL POLYMER CHEMISTRY (Credits: 3)

(Also listed as CHM 665.) Introduction to the structural and physical aspects of macromolecules; emphasis on the relationship of polymer structure to physical and mechanical properties.

PREREQUISITE: CHM 213 OR CHM 561.

BMS 726 SYNTHETIC POLYMER CHEMISTRY (Credits: 3)

(Also listed as CHM 661.) Step-growth and chain-growth polymerization in homogeneous and heterogeneous media; properties of commercial polymers.

PREREQUISITE: CHM 213 OR CHM 561.

BMS 727 PHYSICAL POLYMER CHEMISTRY LABORATORY (Credits: 1 TO 2)

(Also listed as CHM 667.) Laboratory illustrations of BMS 725 lecture material and techniques of polymer science.

PREREQUISITE: CHM 213 OR CHM 561.

BMS 728 POLYMER SYNTHESIS LABORATORY (Credits: 1 TO 2)

Laboratory illustrations of BMS 726 lecture material and techniques of polymer science.

PREREQUISITE: CHM 213 OR CHM 561.

BMS 733 ADVANCED INORGANIC CHEMISTRY I (Credits: 3)

(Also listed as CHM 720.) Study of atomic structure, modern theories of chemical bonding, and structural concepts of inorganic chemistry and their relationships to reactivity, acids and bases in aqueous and nonaqueous systems, and energetics of reactions.

BMS 734 ADVANCED INORGANIC CHEMISTRY II (Credits: 3)

(Also listed as CHM 721.) Thorough examination of coordination chemistry of the metals stressing transition elements, crystal and ligand field approaches and molecular orbital theory as applied to organometallic systems, mechanisms of inorganic reactions, and the role of metal ions in biological systems.

PREREQUISITE: BMS 733.

BMS 735 ADVANCED INORGANIC CHEMISTRY III (Credits: 3)

(Also listed as CHM 722.) Survey of the applications of physical methods in the examination and characterization of inorganic compounds. Emphasis is on methods applied to transition metal complexes.

PREREQUISITE: BMS 734.

BMS 736 CHEMICAL KINETICS (Credits: 3)

(Also listed as CHM 751.) Characterization of simple kinetic systems, experimental methods, energy distributions in molecules, the transition state method, and chain reactions in solution.

PREREQUISITE: CHM 453 OR EQUIVALENT.

BMS 737 CHEMICAL THERMODYNAMICS (Credits: 3)

Fundamentals; first, second, and third laws; and application to solutions.

PREREQUISITE: CHM 453 OR EQUIVALENT.

BMS 738 SELECTED TOPICS IN PHYSICAL CHEMISTRY (Credits: 3)

(Also listed as CHM 855.) Selected topics in the field of physical chemistry such as molecular spectroscopy, advanced molecular structure, magnetic resonance, X-rays and crystal structure, statistical mechanics, or precise physical-chemical measurements.

BMS 740 ADVANCED BIOANALYTICAL CHEMISTRY (Credits: 3)

An introduction to control systems using state variables and classical analysis.Closed loop system representation, block diagrams, time response, and frequency response are treated.

PREREQUISITE: BMS CORE.

BMS 741 STRUCTURAL CONCEPTS IN ORGANIC CHEMISTRY (Credits: 3)

Study of molecular orbital theory, reactive species, theories of acids and bases, and an introduction to stereochemistry.

BMS 742 INSTRUMENTATION (Credits: 3)

Introduction to the theory and practices of modern chemical instrumentation; elementary electronics, spectrophotometry, atomic absorption, electrochemical techniques, chromatography, and other instrumental techniques.

BMS 750 BIOCHEMISTRY AND MOLECULAR BIOLOGY I (Credits: 4 TO 10)

(Also listed as BMB 750.) Survey course emphasizing an experimental and problem-solving approach to buffers, protein structure, enzymes, and carbohydrate and lipid metabolism.

BMS 752 BIOCHEMISTRY AND MOLECULAR BIOLOGY II (Credits: 3 TO 10)

(Also listed as BMB 752.) Survey course emphasizing an experimental and problem-solving approach to amino acid metabolism, nucleic acid function, and hormones.

PREREQUISITE: BMS 750 OR PERMISSION OF INSTRUCTOR.

BMS 753 MOLECULAR SIGNALLING-MOLECULAR CELL BIOLOGY (Credits: 4)

(Also listed as BMB 753.) A molecular analysis of information transfer into and within cells. Topics include visual transduction, hormones, hormone receptors, second messengers, regulation of transcription, and oncogenes. Readings from current scientific literature.

PREREQUISITE: BMS 750, BMS 752.

BMS 755 CANCER: MOLECULAR ASPECTS (Credits: 2 TO 6)

A profile of the general properties of transformed cells and an in-depth examination of the mechanisms of oncogenesis at the level of molecular genetics.

PREREQUISITE: BMS CORE.

BMS 760 MOLECULAR BIOLOGY OF THE NUCLEUS (Credits: 4)

(Also listed as BMB 760.) A literature-based course covering molecular events in the nucleus including DNA replication, repair, recombination, and transcription.

PREREQUISITE: BMB 750, BMB 752.

BMS 762 FUNDAMENTAL PRINCIPLES OF FOURIER TRANSFORM NMR (Credits: 3 TO 6)

(Also listed as BMB 762/PHY 760.) Covers the fundamental theory of nuclear magnetic resonance spectroscopy with emphasis on pulse Fourier transform methods.

PREREQUISITE: BMS CORE.

BMS 763 IN VIVO NMR SPECTROSCOPY AND IMAGING (Credits: 3 TO 6)

(Also listed as BMB 763.) Discusses the applications of NMR spectroscopy to the study of tissue metabolism in vivo. The fundamental theory of magnetic resonance imaging, with a survey of clinical applications, are also presented.

PREREQUISITE: BMS CORE.

BMS 764 NMR TECHNIQUES IN BIOMOLECULAR STRUCTURE AND DYNAMICS (Credits: 3 TO 6)

(Also listed as BMB 764.) Describes the NMR methods used for the determination of biomolecular structure and dynamics. Emphasis on two-dimensional Fourier transform techniques.

PREREQUISITE: BMS CORE.

BMS 765 COMPUTATIONAL TOOLS AND STRATEGIES IN BIOMED SCIENCES (Credits: 4)

This is a survey course of modern computational tools and strategies used in sequence, 3-D structure and functional analysis of biomolecules.Students will gain hands on "laboratory" experience with key software and strategies.

PREREQUISITE: ENROLLMENT IN BMS PROGRAM OR INSTRUCTOR
PERMISSION REQUIRED.

BMS 767 ENZYMES (Credits: 4)

(Also listed as BMB 727.) Mechanism of enzyme catalysis, including such topics as structure, kinetics, energetics, allosterism, co-enzymes, and control of enzymes and multienzyme systems.

PREREQUISITE: BMS 750.

BMS 768 BIOCHEMISTRY OF PEPTIDE HORMONES (Credits: 3)

Synthesis, secretion, degradation, structure assay, mechanism of action, and function of peptide hormones are presented. Emphasis is on insulin and other hormones involved in diabetes mellitus.

PREREQUISITE: BMS 752.

BMS 769 BIOCHEMISTRY OF MEMBRANES (Credits: 4)

(Also listed as BMB 731.) Examines the biochemistry of membranes and provides basic information on membrane composition and processes.

PREREQUISITE: BMS 750 AND 835.

BMS 770 PHYSICAL BIOCHEMISTRY (Credits: 4)

(Also listed as BMB 740.) Structure-function analysis of biological macromolecules (particularly proteins and polynucleotides) based on chemical and physical properties.

PREREQUISITE: BMS 750.

BMS 771 SAFE USE OF RADIONUCLIDES (Credits: 2)

Principles of a, b, and g radiation and methodology of counting with application to physical and biological problems.

BMS 775 PATHOGENIC MECHANISMS (Credits: 5)

(Also listed as M&I 675.) Expands knowledge of basic microbiology by focusing on human-microbial pathogen interactions. The molecular basis of the pathogenic mechanisms will be emphasized. In addition, the student will gain a better appreciation and understanding of the complexities of interactions between microbes and their human hosts.

PREREQUISITE: BIO 210 OR EQUIVALENT MOLECULAR BIOLOGY COURSE
AND BIO 252 OR EQUIVALENT INTRODUCTORY MICROBIOLOGY
COURSE.

BMS 776 BIOENERGETICS (Credits: 1 TO 6)

Structure of energy-transducing membranes of mitochondria, chloroplasts, and bacteria. Emphasis on mechanisms of energy transduction, thermodynamics of oxidation-reduction reactions, biophysical spectroscopic methods, and structure and surface topography of membrane proteins.

PREREQUISITE: BMS 752.

BMS 777 GENE THERAPY (Credits: 4)

(Also listed as M&I 777.) Study of the molecular basis of gene therapy and the use of viral gene delivery systems for the treatment of human disease. Gene therapy strategies are contrasted with various diseases, including cancer and AIDS.

BMS 778 CELL BIOLOGY (Credits: 4)

(Also listed as BIO 730.) Provides a survey of basic concepts that are most important for understanding how cells function.

BMS 779 MOLECULAR GENETICS (Credits: 3)

(Also listed as BIO 734.) Study of the replication, organization, and function of nucleic acids with emphasis on the role of nucleic acids in protein synthesis.

PREREQUISITE: BMS CORE COURSES.

BMS 780 HUMAN GENETICS (Credits: 4)

(Also listed as BIO 626.) Nature of human genetic traits, methods of analysis of inheritance, principles of counseling, and therapy.

PREREQUISITE: BMS 752 AND 835.

BMS 785 ADVANCED SEMILNAR IN GENETICS (Credits: 2)

Review of current literature in molecular or human genetics subjects. Presentation of reviews to other students.

PREREQUISITE: BMS 780.

BMS 786 BEHAVIOR GENETICS (Credits: 3)

Behavior is considered as a population phenomenon and as an adaptive process. Evolutionary theory is used to integrate the disparate aspects of behavioral phenomena.

PREREQUISITE: BMS 780.

BMS 790 RECOMBINANT DNA METHODS (Credits: 6)

(Also listed as BIO 737 and M&I 737.) Microbial and molecular techniques for producing, cloning, and characterizing recombinant DNA molecules; laboratory exercises in gene manipulation to give an understanding of principles of genetic engineering. Graded pass/unsatisfactory.

PREREQUISITE: BMS CORE.

BMS 791 MICROBIAL GENETICS (Credits: 3)

Basic concepts of production of microbial mutations and their detection and analysis. The use of microbial genetics in elucidating cellular functions; the construction of plasmids and their use in genetic engineering.

PREREQUISITE: BMS 752 AND 835.

BMS 793 MICROBIAL ECOLOGY (Credits: 5)

(Also listed as BIO 625.) Microbes in soil, water, and air. Experiments on mineral cycles, physical and biological limiting factors, and symbiosis. Natural communities of microbes and microbes of special human environments. Includes field studies.

BMS 793 MICROBIAL ECOLOGY LABORATORY (Credits: )

Microbes in soil, water, and air. Experiments on mineral cycles, physical and biological limiting factors, and symbiosis. Natural communities of microbes and microbes of special human environments. Includes field studies.

BMS 799 HUMAN PARASITOLOGY (Credits: 2)

(Also listed as BIO 676.) Study of the medical aspects of parasitology such as pathology, symptomatology, diagnosis, and identification of parasites. Course content is divided into three major categories: human protozoology, helminthology, and arthropodology.

BMS 802 IMMUNOLOGY AND BASIC VIROLOGY (Credits: 5)

(Also listed as M&I 726.) Fundamentals of immunobiology and basic virology. Emphasis on regulatory and cellular levels of host immune responses against microbial pathogens as well as mechanisms of immunopathology. Characteristics and molecular biology of virus pathogens.

PREREQUISITE: BMS 752 AND 835.

BMS 803 PATHOGENIC MICROBIOLOGY (Credits: 5)

(Also listed as M&I 727.) Study of microorganisms that are pathogenic for humans and animals using the organ system approach. Emphasis on mechanisms of pathogenesis and host resistance. Includes a project segment devoted to the independent study of the mechanisms of pathogenesis in the host-parasite interactions of the infectious agents used.

PREREQUISITE: BMS 752 AND 835 OR EQUIVALENT.

BMS 805 INTERCELLULAR COMMUNICATION (Credits: 4)

(Also listed as M&I 770, PHA 740, P&B 776.) Introduces concepts of intercellular communication through an interdisciplinary presentation of immune and neuroendocrine system functions. Emphasizes the similarities between the systems and the multidisciplinary approaches used to study each.

BMS 807 BASIC VIROLOGY (Credits: 3)

(Also listed as M&I 731.) Introduction to the field of virology with emphasis on animal viruses. Studies the intrinsic properties of viruses and their interaction with cells; multiplication, disease production, genetics, and tumor induction.

PREREQUISITE: BMS CORE.

BMS 808 MOLECULAR VIROLOGY SEMINAR (Credits: 3)

(Also listed as M&I 831.) Structure, infectious process, replication, maturation, release, and genetics at the molecular level of the major groups of animal viruses.

PREREQUISITE: BMS 752 AND 835.

BMS 809 VIRAL ONCOLOGY SEMINAR (Credits: 3)

(Also listed as M&I 833.) Provides an understanding of the process involved in cell transformation by oncogenic viruses.

PREREQUISITE: BMS 752 AND 835.

BMS 812 IMMUNOBIOLOGY (Credits: 5)

(Also listed as M&I 745.) Study of the biology of the immune system, as well as its function in health and disease. Specific diseases are used as models for immunologically mediated conditions.

PREREQUISITE: BMS 752 AND 835.

BMS 813 SPECIAL TOPICS IN IMMUNOLOGY (Credits: 2 TO 8)

(Also listed as M&I 840.) Students select, present, and analyze information from the current literature in immunobiology.

PREREQUISITE: BMS 752 AND 835.

BMS 818 INFECTION AND IMMUNITY SEMINAR (Credits: 3)

(Also listed as M&I 846.) Deals with the effects of microbial and metazoan parasites on both host resistance and immunologically mediated disease processes.

PREREQUISITE: BMS 752 AND 835.

BMS 834 ELECTRON MICROSCOPY FOR LIFE SCIENCE (Credits: 6)

(Also listed as BIO 740.) Introduction to theoretical and practical aspects of transmission electron microscopy. Emphasis on interpretation and evaluation of electron micrographs. 3 hours lecture, 6 hours lab; additional lab time is required.

PREREQUISITE: PREVIOUS COURSE IN HISTOLOGY OR CELL BIOLOGY.

BMS 835 MAMMALIAN CELL BIOLOGY (Credits: 4 TO 10)

(Also listed as BIO 720.) Interdisciplinary survey of cellular functions, including location of molecular events and functional compartmentation within the cell, recognition of structural and functional elements of the cell, and interaction of cells in specialized tissues.

PREREQUISITE: BMS 750 COREQUISITE.

BMS 837 HUMAN GROSS ANATOMY (Credits: 9)

(Also listed as ANT 711.) Lectures and dissection of human cadaver.

BMS 838 MICROANATOMY (Credits: 8)

Introduction to basic cell structure, including membranes, nucleus, and cytoplasmic organelles. Emphasis on the detailed histological anatomy of the four basic tissues, and major organs and systems of the body.

PREREQUISITE: BMS 751.

BMS 839 DEVELOPMENTAL BIOLOGY (Credits: 3 TO 6)

(Also listed as BIO 603.) Describes underlying processes that initiate the development of tissue and whole organisms in plants and animals.

PREREQUISITE: RECOMMEND BIO 402, BIO 303 OR THE EQUIVALENT.

BMS 840 REPRODUCTIVE ANATOMY AND PHYSIOLOGY (Credits: 3)

Reproductive cycles and gametogenesis; intercourse and conception; events of pregnancy and parturition; contraception, sterility, and dysfunction.

PREREQUISITE: BMS CORE.

BMS 850 BASIC HUMAN PHYSIOLOGY I (Credits: 4 TO 10)

Basic course in structure, function, and interactions of human organ systems. Subject areas include musculoskeletal, neurological, cardiovascular, and respiratory systems.

PREREQUISITE: BMS 752 AND 835.

BMS 850 BASIC HUMAN PHYSIOLOGY I LABORATORY (Credits: )

Basic course in structure, function, and interactions of human organ systems. Subject areas include musculoskeletal, neurological, cardiovascular, and respiratory systems.

BMS 851 BASIC HUMAN PHYSIOLOGY II (Credits: 4 TO 10)

Basic course in structure, function, and interactions of human organ systems. Subject areas include endocrine, gastrointestinal, urinary, and reproductive systems.

PREREQUISITE: BMS 850.

BMS 851 BASIC HUMAN PHYSIOLOGY II LABORATORY (Credits: )

Basic course in structure, function, and interactions of human organ systems. Subject areas include endocrine, gastrointestinal, urinary, and reproductive systems.

BMS 852 CELL PHYSIOLOGY AND BIOPHYSICS (Credits: 4)

(Also listed as P&B 601.) Fundamentals of cellular homeostasis and the role of specialized cells in organismal homeostasis.

PREREQUISITE: ADMISSION TO THE BMS PROGRAM.

BMS 853 ION CHANNELS (Credits: 4)

(Also listed as P&B 722.) Explores the role of ion channels in a variety of cell types with an emphasis on both electrophysiological and biochemical methods for evaluation of channel function.

PREREQUISITE: BMS 852 AND/OR PERMISSION OF INSTRUCTOR.

BMS 854 MEDICAL NEUROSCIENCE (Credits: 7)

(Also listed as ANT 777 and P&B 777.) Interdisciplinary/interdepartmental course for medical and graduate students that integrates basic and clinical neurosciences. Structural and functional topics are combined with clinical information to address major neurological and psychiatric disorders.

PREREQUISITE: BMS CORE COURSES.

BMS 856 GLIAL CELL PHYSIOLOGY (Credits: 3)

(Also listed as P&B 650.) Concepts of glial cell physiology based on the analysis of current primary literature. Topics include interaction between glia and other cell types and the role of glia in pathophysiology.

PREREQUISITE: P&B 642.

BMS 859 GASTROINTESTINAL PHYSIOLOGY AND BIOPHYSICS (Credits: 3)

(Also listed as P&B 761.) Principles of gastrointestinal physiology and biophysics emphasizing cellular mechanisms of secretions, absorption, and motility.

PREREQUISITE: BMS CORE.

BMS 860 GENERAL ENDOCRINOLOGY (Credits: 3)

(Also listed as P&B 771.) Survey of endocrinological mechanisms and their role in integration of body function.

PREREQUISITE: BMS 851 OR PERMISSION OF INSTRUCTOR.

BMS 862 HUMAN PHYSIOLOGY (Credits: 5)

(Also listed as P&B 610.) An overview of human/mammalian organ system physiology. Fundamental mechanisms and the experimental basis for current understanding are emphasized.

BMS 864 PHYSIOLOGICAL ASPECTS OF EXERCISE (Credits: 5)

(Also listed as P&B 783.) Integration of physiological mechanisms involved in exercise. Cellular, neuromuscular, cardiovascular, and respiratory changes are discussed with relationship to exercise performance.

PREREQUISITE: BMS CORE.

BMS 865 INTRODUCTORY NEUROPHYSIOLOGY (Credits: 4)

(Also listed as P&B 642.) Physiological mechanisms that subserve the functions of the nervous system. Topics include the biophysics of neuronal information, intercellular communications, motor
control, sensory systems, and development neurobiology.

PREREQUISITE: BMS 852.

BMS 866 CARDIOVASCULAR PHYSIOLOGY (Credits: 3)

(Also listed as P&B 733.) Survey of the physiology of the human cardiovascular system; components and control, cell, organ, and system level. Both newborn and adult are included, as well as adjustments to exercise and non-exercise stress.

PREREQUISITE: ENROLLMENT IN THE BMS PH.D. PROGRAM.

BMS 867 FLUORESCENCE: THEORY AND PRACTICE (Credits: 1 TO 3)

(Also listed as P&B 704.) Covers the theoretical basis for fluorescence and instrument design in this methods-oriented course. Applications of interest to the physiological and biochemical sciences are discussed.

PREREQUISITE: BMS 750; BMS 752.

BMS 868 MOLECULAR BASIS OF SECRETION (Credits: 1 TO 5)

(Also listed as P&B 751.) Explores current hypothesis for the formation, sorting, and release of secretory vesicles at a molecular level of integrating ideas from cell biology, neuroscience, and membrane biophysics. Methodology is emphasized.

PREREQUISITE: BMS 852.

BMS 869 QUANTITATIVE ASPECTS OF MEMBRANE TRANSPORT (Credits: 3 TO 10)

(Also listed as P&B 669.) Employs a quantitative approach to the properties of solutes, water, bio-electrical phenomena, transport systems that move solutes across biological membranes, and the interactions of these solutes with membranes. May be taken for letter grade or pass/unsatisfactory.

PREREQUISITE: BMS 835 AND BMS 852.

BMS 870 PHYSIOLOGY AND PHARMACOLOGY OF VASCULAR CELLS (Credits: 3)

(Also listed as PHA 870 and P&B 870.) Study of physiological steady state and pharmacological properties of vascular cells-circulating erythrocytes, endothelial cells, and smooth muscle cells in particular-as a basis of pathologic aberrations and clinical disorders.

PREREQUISITE: CELL BIOLOGY, CELL BIOPHYSICS, OR EQUIVALENT.

BMS 872 MECHANISMS OF CELL DEATH (Credits: 3)

Signalling and molecular mechanisms of apoptotic cell death and relationship to human diseases.

BMS 876 PRINCIPLES OF BIOKINETICS (Credits: 4)

Abbreviated course describing passage of drugs across membranes, their mechanisms of action, distribution, biotransformation, and elimination. Discusses dose-response relationships, receptor-binding kinetics, and topics of interest and importance to enrolled students.

BMS 879 MOLECULAR PHARMACOLOGY (Credits: 4)

Introduces students to drug-receptor interactions, dose-response relationships, physiochemical principles of drug action and distribution, pharmacokinetics, mechanisms of action, and uses of drugs affecting both autonomic and central nervous system functions.

PREREQUISITE: BMS CORE.

BMS 880 GENERAL PHARMACOLOGY II (Credits: 4)

(Also listed as PHA 880.) Extends the principles and theoretical considerations learned in BMS 879 and applies them to the action of drugs on the cardiovascular, respiratory, endocrine, gastrointestinal, and genito-urinary systems. Emphasis on antibiotics, chemotherapy of infectious diseases, antineoplasia, and immuno-suppressants. An introduction to toxicology is provided.

PREREQUISITE: BMS 879.

BMS 881 RESEARCH TECHNIQUES (Credits: 3)

Practical laboratory experience in commonly used biological techniques including DNA purification and manipulation, protein expression and analysis, and the classical pharmacological technique of measuring receptor binding.Designed to give hands on experience along with a short weekly lecture providing background on the theory behind the topic.

BMS 886 GENERAL PATHOLOGY (Credits: 7)

Introduces basic principles of abnormal biological processes in the human and subhuman vertebrate organisms. Deals with tissue injury and degeneration, abnormal growth, infection and host defense, selected metabolic and congenital disorders, and forensic problems. Complies with the Toxicology Society's recommended requirements for the professional toxicologist.

PREREQUISITE: BMS CORE.

BMS 887 MOLECULAR TOXICOLOGY (Credits: 4)

Introduction to general toxicology covering the principles of intoxication and detoxication, classification of poisons, exposure characteristics, biotransformation and biokinetics of poisons, systemic toxicology including central nervous system, splanchnic organs, cardiovascular, hematopoietic, respiratory, reproductive, and skeletal systems.

PREREQUISITE: BMS 880.

BMS 888 GENERAL TOXICOLOGY II (Credits: 4)

(Also listed as PHA 752.) Introduction to general toxicology. Particular toxic agents are studied, including teratogens, mutagens, oncogens, heavy metals, and other environmental contaminants and toxins. Clinical, forensic, industrial, and agricultural toxicology are addressed along with regulations that apply to the field.

PREREQUISITE: BMS 887.

BMS 889 TOXICOLOGIC PATHOLOGY (Credits: 3)

The pathobiology of toxic chemicals and materials is presented with emphasis placed on anatomic and physiologic changes produced in common laboratory animal species.Research methods enhancing the pathologic evaluation of biomedical specemens will be stressed.

PREREQUISITE: BMS 886.

BMS 890 PRINCIPLES OF BIODYNAMICS (Credits: 4)

Covers the general basis of toxicology and therapeutics: pharmacokinetics, xenobiotic metabolism, and their effects on determination of the dose-response-time relationship.

PREREQUISITE: CORE CURRICULUM OR EQUIVALENT OR PERMISSION OF
INSTRUCTOR.

BMS 898 NEUROPHARMACOLOGY (Credits: 3)

(Also listed as PHA 898.) In-depth treatment of the anatomy, biochemistry, physiology, and function of neurotransmitter systems and the effects of drugs on the nervous system.

PREREQUISITE: BMS CORE AND BMS 876 OR EQUIVALENT OF BOTH,
PLUS PERMISSION OF DIRECTOR.

BMS 902 NEUROPHYSIOLOGY (Credits: 3)

(Also listed as P&B 720.) Survey of neurophysiology with emphasis on somatic and autonomic control of body function.

PREREQUISITE: BMS CORE.

BMS 903 HUMAN NEUROANATOMY (Credits: 7)

(Also listed as ANT 731.) Detailed survey of the anatomy and physiology of the major fiber tracts and cell groups of the human central nervous system.

PREREQUISITE: BMS CORE.

BMS 905 INFORMATION PROCESSING (Credits: 4)

(Also listed as PSY 665.) Survey of experimental findings in animal and human memory with emphasis on their implications for current theories of memory.

PREREQUISITE: BMS CORE.

BMS 910 PSYCHOBIOLOGY OF STRESS (Credits: 4)

(Also listed as PSY 619.) Detailed examination of selected areas in cognition and learning.

PREREQUISITE: BMS CORE CURRICULUM.

BMS 913 FUNDAMENTALS OF HUMAN NEUROBIOLOGY (Credits: 4)

(Also listed as ANT 691.) Development, structure, and function of the human nervous system as it relates to neuropathology, clinical neurology, and behavioral science.

PREREQUISITE: GENERAL BIOLOGY AND/OR GENERAL PSYCHOLOGY.

BMS 914 BEHAVIORAL NEUROSCIENCE (Credits: 4)

(Also listed as PSY 891.) Covers neurobiological bases of behavior. Focuses on motor function, ingestion, mating, learning, memory, rhythmical influences, and emotion.

PREREQUISITE: BMS CORE OR EQUIVALENT.

BMS 925 FUNDAMENTALS OF BIOLOGICAL COMPUTATION AND MODELING (Credits: 5)

This course will treat fundamental programming approaches, data structures and mathematical/statistical principles used in designing computational biology tools and algorithms.Students will learn theoretical principles and gain practical experience.

PREREQUISITE: ADMISSION REQUIREMENTS FOR BMS PROGRAM PLUS
PROGRAMMING EXPERTISE.

BMS 950 CARDIAC MECHANICS (Credits: 1 TO 6)

This course teaches BMS Ph.D students a variety of mathematical models which have been developed to describe cardiac performance in health and disease.

PREREQUISITE: BMS CORE.

BMS 951 CARDIOPULMONARY MODELING (Credits: 1 TO 6)

(Also listed as BME 712.) Acquaints students with the analytical, numerical, and experimental methods used in modeling the quantitative behavior of physiological and artificial organ systems, particularly the circulation and the lungs.

PREREQUISITE: BMS CORE.

BMS 952 BIOCOMPATIBILITY OF MATERIALS (Credits: 1 TO 6)

(Also listed as BME 713.) Acquaints students with the concept of biocompatibility of materials, including effects on biological systems. Deals with the general problem of selection, qualification, and specification of materials.

PREREQUISITE: BMS CORE.

BMS 953 HUMAN FACTORS ENGINEERING ADVANCED AEROSPACE SYSTEMS DESIGN (Credits: 1 TO 6)

(Also listed as HFE 724.) Qualifies students to make significant human factors contributions to the design of state-of-the-art aerodynamic and space systems. Design of control-display integration, cockpit configuration, maintainability, and reliability emphasized.

PREREQUISITE: BMS CORE.

BMS 954 HUMAN FACTORS ENGINEERING WORKLOAD ANALYSIS (Credits: 1 TO 6)

(Also listed as HFE 725.) Provides students with tools required to accomplish a workload analysis as a requisite to a systems design or a redesign of an existing system.

PREREQUISITE: BMS CORE.

BMS 955 HUMAN FACTORS ENGINEERING: CREW STATION DESIGN (Credits: 1 TO 6)

(Also listed as HFE 726.) In-depth treatment of human factors engineering principles applicable to design of crew command centers for aerodynamics, space, and maritime systems.

PREREQUISITE: BMS CORE.

BMS 956 MEDICAL ULTRASONICS (Credits: 1 TO 6)

(Also listed as BME 731.) Fundamentals of medical ultrasonics: ultrasound generation, propagation, scattering, and attenuation in biological tissue. A-mode, B-mode, M-mode, and Doppler imaging techniques. Ultrasound tissue characterization and quantitative imaging techniques.

PREREQUISITE: BMS CORE.

BMS 957 COMPUTED TOMOGRAPHY (Credits: 1 TO 6)

(Also listed as BME 732.) Principles of generating images from projections. Discussion of the various scanner geometries, mathematical reconstruction, correction procedures, and qualitative and quantitative evaluation of images. A major focus is the medical application of computed tomography.

PREREQUISITE: BMS CORE.

BMS 958 NUCLEAR MAGNETIC RESONACE IN MEDICINE (Credits: 1 TO 6)

(Also listed as BME 733.) Principles of imaging and spectroscopy of nuclear magnetic resonance in their application to medicine. Topics include magnetization models, material encoding, spin interactions, localized spectroscopy, and relaxation.

PREREQUISITE: BMS CORE.

BMS 959 PROCESSING OF MEDICAL IMAGES (Credits: 1 TO 6)

(Also listed as BME 734.) Digital image processing in its application to medical images. Topics include image display, filtering, two-dimensional Fourier transform, restoration, enhancement, and edge detection. Some simple tools from the field of mathematical morphology are also introduced.

PREREQUISITE: BMS CORE.

BMS 960 PHOTON EMISSION IMAGING (Credits: 1 TO 6)

(Also listed as BME 735.) Principles of imaging procedures based on radioactive isotopes. Topics include radioactive isotopes, single-photon emission tomography, and positron-emission tomography. Instrumentation, image production, and major applications are covered.

PREREQUISITE: BMS CORE.

BMS 961 NEUROMUSCULAR REHABILITATION ENGINEERING (Credits: 1 TO 6)

(Also listed as BME 741.) Teaches the design and application of neuromuscular assistive devices. Biomathematics modeling and control theory are emphasized.

PREREQUISITE: BMS CORE.

BMS 962 REHABILITATION ASSISTIVE SYSTEMS (Credits: 1 TO 6)

(Also listed as BME 742.) Design and application of devices used in rehabilitation. Provides an understanding of the problems of disabled people and the variety of possible solutions to these problems.

PREREQUISITE: BMS CORE.

BMS 963 APPLICATION OF HUMAN FACTORS ENGINEERING TO REHABILITATION (Credits: 1 TO 6)

(Also listed as HFE 743.) Teaches students application of human factors design concepts to the design of aids for the physically handicapped. In addition to aids for manipulation of locomotion, barrier-free designs are emphasized.

PREREQUISITE: BMS CORE.

BMS 964 AEROSPACE MEDICINE HUMAN FACTORS (Credits: 3)

Designed for BMS students who are residents of the Aerospace Medicine Program. Seminar focuses on recent developments in human factors engineering. Addresses design principles, crew compartment technology and resource management, crew members performance and reliability.

PREREQUISITE: BMS CORE AND PERMISSION OF PROGRAM DIRECTOR.

BMS 965 HUMAN FACTORS ENGINEERING ADVANCES IN VISUAL DISPLAY DESIGN (Credits: 3)

Application of human factors engineering principles to the design of visual display systems.Discusses current display technologies, human vision, design of display parameters, and image quality metrics.

PREREQUISITE: BMS CORE.

BMS 966 ADVANCED TOPICS IN HUMAN-COMPUTER INTERACTION (Credits: 3)

This graduate-level seminar exposes students to theoretical and research issues associated with human-computer interaction (HCI) and cognitive-oriented work from a human factors engineering standpoint.

PREREQUISITE: BMS CORE.

BMS 967 ADVANCED DEVELOPMENT BIOLOGY (Credits: 4)

Molecular mechanism of development, including topics such as; cell signalling, pattern formation, terminal differentiation.

PREREQUISITE: BIO 210, 211, 212 OR EQUIVALENT, OR INSTRUCTOR
APPROVAL.

BMS 990 BIOMEDICAL SCIENCES SEMINAR (Credits: 1 TO 3)

(Also listed as P&B 808.) Convention of student body and faculty in biomedical sciences to learn, discuss, and critique the basic and clinical biomedical literature as presented by an active and reputable scientific investigator. Student presentations required.

BMS 991 SPECIAL TOPICS (Credits: 1 TO 15)

Selected topics in biomedical sciences.

BMS 994 INTRODUCTION TO RESEARCH (Credits: 1 TO 6)

Introduces BMS students to the ongoing research activities within the five program tracks; involves presentations by BMS faculty. Graded pass/unsatisfactory.

BMS 995 NON-DISSERTATION RESEARCH (Credits: 1 TO 15)

Supervised research other than laboratory rotations or dissertation research. May be taken for letter grade or pass/unsatisfactory.

BMS 996 LABORATORY ROTATION I (Credits: 1 TO 15)

Independent study designed to develop proficiency in technology, instrumentation, research design, and data analysis in an area of concentration (advanced curriculum) different from a student's area of specialization.

BMS 997 LABORATORY ROTATION II (Credits: 1 TO 15)

BMS 998 LABORATORY ROTATION III (Credits: 1 TO 15)

BMS 999 DISSERTATION RESEARCH (Credits: 1 TO 15)

Planning and execution of scholarly original research of a quality that is publishable in a referred, scientific journal. Research must be communicated to the supervisory committee in written form and defended by public, oral examination.

PREREQUISITE: AS DETERMINED BY SUPERVISOR AND SUPERVISORY
COMMITTEE.