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Wayne Carmichael's lab homepage BIOLOGY 415/615 - Introduction to Toxicology

DR. WAYNE CARMICHAEL Winter 2005

Offered Again in Spring, 2006

Course Description BIO 415/615 - 4 cr. hr. - Introduction to Toxicology

This course covers the basic principles of toxicology using toxicant examples that emphasize sources and types from the environment. Principles covered include toxicokinetics (uptake, distribution, biotransformation), measurement of toxicity, systems toxicology (liver, neuro, kidney, dermal, respiratory, carcinogenesis) and risk assessment/management.

Prerequisite: Courses in animal physiology and organic chemistry

Method of Presentation:

The academic work will be presented in two 90-minute lecture sessions weekly.

Determination of Grades:

Final grade for the quarter will be based on a cumulative total of 275 points (225 pts. exams, 50 pts. problems). Grades will be assigned on a distribution of the 275 points. The exact distribution will be determined by the class performance as a whole. There will be no make-up examinations given--please let me know ASAP if an exam will be/has been missed.

Drop Date:

January 21, 2005 - Last day for all students to drop a class without a grade

Projects:

For BIO 615 or BMS credit students, a review paper is required.

Texts:

*Basic Toxicology. F.C. Lu. 2002 (3 day reserve - Dunbar Library).

**Hodgson and Guthrie. Introduction to Biochemical Toxicology. 3rd ed.

(24 hour reserve - Dunbar Library)

Additional Reference Texts:

Klaassen, C.O. (ed.) 1996. Casarett and Doull's Toxicology: the Basic Science of Poisons.

5th ed. McGraw-Hill. 1111 pp.

Niesink, R.J.M., J. de Vries, and M.A. Hollingen. (eds.) 1996. Toxicology - Principals and

Applications. CRC Press. Boca Raton, Florida. 1284 pp.

Ballantyne, B., Marrs, T., and Syversen, T. (eds.) 2000. General and Applied Toxicology.

2nd Ed. McMillan Ref. Ltd. Grove's Dictionaries Inc. Vol. 1-3.

Massaro, E.J. (ed.) 2002. Handbook of Neurotoxicology.

Human Press. Volume 1-2.

***Essentials of Environmental Toxicology--W. William Hughes. Taylor and Francis. 1996***

***This is a good summary text for toxicology.***

LECTURE SCHEDULE
BIO 415/615 - Introduction to Toxicology
Winter 2005

Lectures: 10:25-12:05 p.m. - Tuesday & Thursday 105 Biological Sciences Hall

Prof. Wayne W. Carmichael - Office: Fawcett 025A (enter through Fawcett 021)
Office Hours: Tuesday, Thursday 9:30-10:25 a.m.
Phone: 937-775-3173, FAX: 937-775-3320, Email: wayne.carmichael@wright.edu
Laboratory and Teaching Website: http://www.wright.edu/biology/faculty/carmichael/labhome/labhome.htm

TUESDAY THURSDAY

Jan. 4
Introduction - Fields of Toxicology
Ch. 1- Lu* Jan. 6
Sources and Types of Toxicants
Ch. 19-23 - Lu* (general concepts)

Jan. 11
Sources and Types of Toxicants (cont)
Chemical and Biol. Warfare Agents
Ch. 19-23 - Lu* (general aspects) Jan. 13 -- Quiz #1 - 25 pts (30 minutes)
Absorption, Distribution, Excretion
Ch. 2, 3 - Lu*

Jan. 18
Absorption, Distribution, Excretion (cont)
Ch. 1 - H & G** Jan. 20
Toxicokinetics
Ch. 1 - H & G**

Jan. 25
No class--at AWWA Source Water Protection Symposium Jan. 27
Measurement of Toxicity
Ch. 4, 5, 6 - Lu *
Handout Problem Set

Feb. 1
Measurement of Toxicity
Ch. 4, 5, 6 - Lu * Feb. 3
Toxic Action - Hepatotoxicity
Ch. 13 - Lu*
Problem Set Due by 5 pm

Feb. 8
Quiz #2 - 60 pts (90 minutes)
(No lecture)
Feb. 10 Toxic Action - Hepatotoxicity
Ch. 13

Feb. 15
Toxic Action - Neurotoxicity and Nephrotoxicity
Ch. 17, 14 - Lu* Feb. 17
Toxic Action - Neurotoxicity and Nephrotoxicity
Ch. 17, 14 - Lu*

Feb. 22
Toxic Action - Dermal and Respiratory Toxicity
Ch. 15, 12 - Lu* Feb. 24
Toxic Action - Dermal and Respiratory
Toxicity (cont.)
Ch. 15, 12 - Lu*

March 1
Quiz #3- 40 pts (1 hour)
Carcinogenicity
Ch. 7 - Lu* March 3
Carcinogenesis and Mutagenesis
Ch. 7, 8 - Lu*
Immunotoxicology
Ch. 11 - Lu*

March 8
Ecotoxicology
Hazard and Risk Assessment
Ch. 24, 25 - Lu* March 10
Hazard and Risk Assessment (cont.)
Ch. 24, 25 - Lu*
Course Summary/Review

Saturday March 12 -- Last day of classes
March 14-19 -- Finals Week
FINAL EXAM - (100 pt. Comprehensive)
Thursday - March 17; 10:30 a.m. - 12:30 p.m.
See Sample exam questions March 21-25 Spring Break Week
March 28 - Spring Quarter Begins

TUESDAY	THURSDAY
Jan. 4 Introduction - Fields of Toxicology Ch. 1- Lu*	Jan. 6 Sources and Types of Toxicants Ch. 19-23 - Lu* (general concepts)
Jan. 11 Sources and Types of Toxicants (cont) Chemical and Biol. Warfare Agents Ch. 19-23 - Lu* (general aspects)	Jan. 13 -- Quiz #1 - 25 pts (30 minutes) Absorption, Distribution, Excretion Ch. 2, 3 - Lu*
Jan. 18 Absorption, Distribution, Excretion (cont) Ch. 1 - H & G**	Jan. 20 Toxicokinetics Ch. 1 - H & G**
Jan. 25 No class--at AWWA Source Water Protection Symposium	Jan. 27 Measurement of Toxicity Ch. 4, 5, 6 - Lu * Handout Problem Set
Feb. 1 Measurement of Toxicity Ch. 4, 5, 6 - Lu *	Feb. 3 Toxic Action - Hepatotoxicity Ch. 13 - Lu* Problem Set Due by 5 pm
Feb. 8 Quiz #2 - 60 pts (90 minutes) (No lecture)	Feb. 10 Toxic Action - Hepatotoxicity Ch. 13
Feb. 15 Toxic Action - Neurotoxicity and Nephrotoxicity Ch. 17, 14 - Lu*	Feb. 17 Toxic Action - Neurotoxicity and Nephrotoxicity Ch. 17, 14 - Lu*
Feb. 22 Toxic Action - Dermal and Respiratory Toxicity Ch. 15, 12 - Lu*	Feb. 24 Toxic Action - Dermal and Respiratory Toxicity (cont.) Ch. 15, 12 - Lu*
March 1 Quiz #3- 40 pts (1 hour) Carcinogenicity Ch. 7 - Lu*	March 3 Carcinogenesis and Mutagenesis Ch. 7, 8 - Lu* Immunotoxicology Ch. 11 - Lu*
March 8 Ecotoxicology Hazard and Risk Assessment Ch. 24, 25 - Lu*	March 10 Hazard and Risk Assessment (cont.) Ch. 24, 25 - Lu* Course Summary/Review
Saturday March 12 -- Last day of classes March 14-19 -- Finals Week FINAL EXAM - (100 pt. Comprehensive) Thursday - March 17; 10:30 a.m. - 12:30 p.m. See Sample exam questions	March 21-25 Spring Break Week March 28 - Spring Quarter Begins

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