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A Randomized, Double Blind, Parallel, Multi-Center, Placebo-Controlled, Two Year Study to Determine the Efficacy and Safety of Orally Administered 5 and 15 mg/day, and 50 mg/week Risedronate in Patients with Medial Compartment Knee Osteoarthritis in North America

This is a double-blind trial to investigate the efficacy of a biphosphonate in knee osteoarthritis. Patients with knee pain, 40-80 years old and otherwise in good health are entered into the two-year study. After a telephone interview and a screening visit, the participants are randomly assigned to one of the three treatment groups or to the control group. The study procedures include radiographs of the knee, blood and urine collection and some questionnaires. The participants come back to the laboratory for follow-up visits every three months.

Recruitment for the study is closed.

Updated January, 2013