Williams, Michael T.

ACADEMIC EXPERIENCE

Research Instructor - Pharmacology Research Center, Children’s Hospital Research Foundation (December 2000 - present)

Faculty member of the University of Cincinnati graduate program in Neuroscience (July 2001-present)

Adjunct Instructor of Psychology (Sept. 2000 – present), Sinclair Community College

Adjunct Assistant Professor of Psychology (Sept. 1997 – June 2000), Wright State University

EDUCATION

Post-Doctoral Fellow in Teratology (October 1997- October 2000)
Children’s Hospital Research Foundation, Mentor - Professor Charles V. Vorhees, Ph.D.
Research: substituted-amphetamines, learning and memory, neuroendocrinology, neurotoxicology

Post-Doctoral Fellow in Psychoneuroimmunology (July 1997-Sept 1997)
The Ohio State University; Mentor –Phillip T. Marucha, D.M.D., Ph.D.
Research: stress, immunity

Ph.D. - Biomedical Sciences (June, 1997), Dissertation title: The effects of restraint, bright lights, and heat during gestation on pregnant female rats, their fetuses, and offspring: emphasis on the hypothalamic-pituitary-adrenal axis. Wright State University. Dissertation Advisor – Harry N. Davis, Jr., Ph.D. (Deceased 1999).

B.S. - Psychology (1990), Wright State University

A.A. - Psychology (1987), Belleville Area College

HONORS, AWARDS

Post-doctoral Travel Fellowship to attend International Behavioral Neuroscience Society meeting, June 1999

Travel award to attend Midwest Teratology Association, May 1996

Omnitech Travel Fellowship to attend Society of Neuroscience, November 1995

Travel Fellowship to attend International Behavioral Neuroscience Society, April 1993

Graduated (B.S.), Magna Cum Laude, Wright State University, December 1990

Outstanding Achievement in Psychology, Belleville Area College, May 1987

EXTRAMURAL SUPPORT

Developmental interactions of methamphetamine and stress. (NIDA, 1 K01 DA14269-01, $577,690 over 5 years).

ADHD phenotype network: Animal model to clinical trial. (PI: Floyd R. Sallee, NIMH, 1 R21 MH66212-01, pending score 169).

PUBLICATIONS

Williams, M. T., Morford, L. L.,. Wood, S. L.,. Rock, S. L., McCrea, A. E., Fukumura, M., Wallace, T. L., Broening, H. W., Moran, M. S., & Vorhees, C. V. (in preparation). Learning and memory deficits in adulthood following administration of MDMA to rats from postnatal day 11-20: the use of large litter size to control for MDMA-induced weight decrement.

Williams, M. T., Morford, L. L., Wood, S. L., Wallace, T. L., Fukumura, M., Broening, H. W., and Vorhees, C. V. (submitted). Developmental d-methamphetamine treatment selectively induces spatial navigation impairments in reference memory in the Morris water maze while sparing working memory.

Williams, M. T., Morford, L. L., McCrea, A. E., Wood, S. L., and Vorhees, C. V. (submitted). Administration of d,l-fenfluramine to rats produces learning deficits in the Cincinnati water maze but not the Morris water maze: Relationship to adrenal cortical output.

Williams, M. T., Vorhees, C. V., Boon, F., Saber, A. J., and Cain, D. P. (provisionally accepted). Methamphetamine exposure from postnatal day 11 to 20 causes impairments in both behavioral strategies and spatial learning in adult rats.

Morford, L. L., Wood, S. L., Gudelsky, G. A., Williams, M. T., and Vorhees, C. V. (provisionally accepted). Impaired spatial and sequential learning in rats treated neonatally with d-fenfluramine.

Brown, C. A., Williams, M. T., and Vorhees, C. V. (In press). Long-term effects from developmental exposure to amphetamine, methamphetamine and MDMA. The Neuroscientist.

Williams, M. T., Morford, L. L., McCrea, A. E., Inman-Wood, S. L., & Vorhees, C. V. (2001). Elevations in plasmatic titers of corticosterone and aldosterone, in the absence of changes in ACTH, testosterone, or glial fibrillary acidic protein, 72 hours following d,l-fenfluramine or d-fenfluramine administration to rats. Neurotoxicology and Teratology 23 (1), 32-39.

Williams, M. T., Inman-Wood, S. L., Morford, L. L., McCrea, A. E., Ruttle, A. M., Moran, M. S., Rock, S. L., & Vorhees, C. V. (2000). Preweaning treatment with methamphetamine induces increases in both corticosterone and ACTH in rats. Neurotoxicology and Teratology, 22 (5), 751-759.

Inman-Wood, S. L., Williams, M. T., Morford, L. L., & Vorhees, C. V. (2000). Effects of prenatal cocaine on Morris and Barnes maze tests of spatial learning and memory in the offspring of C57BL/6J mice. Neurotoxicology and Teratology, 22, 547-557.

Hennessy, M. B., Davis, H. N., McCrea, A. E., Harvey, A. T., & Williams, M. T. (1999). Short- and long-term consequences of corticotropin-releasing factor in early development. Annals of the New York Academy of Sciences, 897, 76-91.

Williams, M. T., McCrea, A. E., Hennessy, M. B., &. Davis, H. N. (1999). Stress during pregnancy alters the offspring hypothalamic, pituitary, adrenal, and testicular response to isolation on the day of weaning. Neurotoxicology and Teratology, 21(6), 653-659.

Williams, M. T., Davis, H. N., McCrea, A. E., Long, S. J., & Hennessy, M. B. (1999). Changes in the hormonal concentrations of pregnant rats and their fetuses following multiple exposures to a stressor during the third trimester. Neurotoxicology and Teratology, 21(4), 403-414.

Hennessy, M. B., Williams, M. T., Miller, D. D., Douglas, C. W., & Voith, V. L. (1998). Influences of male and female petters on plasma cortisol and behaviour: Can human interaction reduce the stress of dogs in a public animal shelter? Applied Animal Behaviour Science, 61, 63-77.

Williams, M. T., Davis, H. N., McCrea, A. E., & Hennessy, M. B. (1998). The distribution of radiolabeled corticotropin-releasing factor in pregnant rats: An investigation of placental transfer to the fetuses. International Journal of Developmental Neuroscience, 16(3/4), 229-234.

Williams, M. T., Hennessy, M. B., & Davis, H. N. (1998). Stress during pregnancy alters rat offspring morphology and ultrasonic vocalizations. Physiology & Behavior, 63(3), 337-343.

Hennessy, M. B., Davis, H. N., Williams, M. T., Mellott, C., & Douglas, C. (1997). Plasma cortisol levels of dogs at a county animal shelter. Physiology & Behavior, 62(3), 485-490.

Williams, M. T., Hennessy, M. B., & Davis, H. N. (1995). CRF administered to pregnant rats alters offspring behavior and morphology. Pharmacology, Biochemistry, & Behavior, 52, 161-167.

Hennessy, M. B., Long, S. J., Nigh, C. K., Williams, M. T., & Nolan, D. J. (1995). Effects of peripherally administered corticotropin-releasing factor (CRF) and a CRF antagonist: Does peripheral CRF activity mediate behavior of guinea pig pups during isolation? Behavioral Neuroscience, 109, 1137-1145.

Hennessy, M. B., O'Neil, D. R., Becker, L. A., Jenkins, R., Williams, M. T., & Davis, H. N. (1992). Effects of centrally administered CRF and alpha-helical CRF on the vocalizations of isolated guinea pig pups. Pharmacology, Biochemistry, & Behavior, 43, 37-43.

PUBLISHED ABSTRACTS

Vorhees, C. V., Williams, M. T., Boon, F., Saber, A., and Cain, D. P. (2002, in press). An analysis of factors contributing to P11-20 methamphetamine-induced spatial learning deficits. Neurotoxicology and Teratology.

Williams, M. T., Morford, L. L., Inman-Wood, S. L., Rock, S. L., McCrea, A. E., Fukumura, M., Wallace, T.L., Broening, H. W., Moran, M. S., Berry, H.K. & Vorhees, C. V. (2001). Learning and memory deficits in adulthood following administration of MDMA to preweaning rats: consideration of undernutrition and stress. Society for Neuroscience Abstracts.

Faught M. R., Williams, M. T. & Vorhees, C. V. (2001) Long-term changes in gene expression in the brain due to developmental exposure to 3,4-methylenedioxymethamphetamine. Society for Neuroscience Abstracts

Vorhees, C. V., Morford, L .L., Broening, H. W., Fukumura, M., Inman-Wood, S. L., Wallace, T. L., &. Williams, M. T. (2001). P11-20 d-methamhetamine treatment induces reference memory-based learning deficits while sparing sequential and cued learning and working memory. Neurotoxicology and Teratology, (in press) & Society for Neuroscience Abstracts.

Rock, S. L., Vorhees, C. V., & Williams, M. T. (2000). Dopamine-1 receptor alteration following postnatal methamphetamine treatment. Society for Neuroscience Abstracts

Morford, L. L., Inman-Wood, S. L., McCrea, A. E., Vorhees, C. V., & Williams, M. T. (1999). Persistent increase in adrenal output without concurrent gonadal alterations in male rats three days following acute d,l-fenfluramine exposure. The Toxicologist

Inman, S. L., Morford, L. L., Williams, M. T., & Vorhees, C. V. (1998). Prenatal cocaine treatment in C57BL/6 mice affects Barnes maze performance. Neurotoxicology and Teratology, 20(3), 359.

Williams, M. T., McCrea, A. E., Hennessy, M. B., & Davis, H. N. (1996). Effects of variations in reproductive activity on hypothalamic, pituitary, adrenal, and testicular hormones in male rats. Society for Neuroscience Abstracts., 22(Part 1), 156.

McCrea, A. E. & Williams, M. T. (1996). Maintaining pregnant rats on a standard vs. reversed light/dark cycle: Implications for gestational stress. Society for Neuroscience Abstracts., 22(Part 1), 462.

Williams, M. T., Hennessy, M. B., & Davis, H. N. (1995). The pituitary-adrenal response to separation in a novel environment is attenuated in prenatally stressed, preweanling rat offspring. Society for Neuroscience Abstracts., 21(Part 1), 501. Also, poster session presented at Wright State University's International Neuroscience Symposium, Dayton, OH.

Davis, H. N., Williams, M. T., Benghuzzi, H. A., England, B. G., & Bajpai, P. K. (1992). Sustained release of testosterone and dihydrotestosterone by ALCAP ceramic implants in rats. Journal of Investigative Surgery, 5, 255.

INVITED TALKS

Williams, M. T. & Vorhees, C. V. Development of the hypothalamic-pituitary-adrenal axis: consequences of early drug exposure. Annual meeting of the Society of Toxicology (March, 2000). The Toxicologist 54(1) :414.

Williams, M. T. Research opportunities in Behavioral Neuroscience. Address to the Psi Chi Honor Society at Sinclair Community College, Dayton, OH (January, 2000) and Psychology Career Days (October 2001).

Williams, M. T. Behavioral and neuroendocrine effects of substituted amphetamines throughout development. Bio-Psy Seminar at Evansville College, Evansville, IN (December, 1999).

Williams, M. T. Environmental factors that may confound neurotoxicological studies. Neurotoxicology and Neurotoxicity Testing workshop, Argus Laboratories, Horsham, PA. (September, 1999).

PRESENTATIONS

Crawford, C. A., Williams, M. T., Newman, E. R., Zavala, A. R., McDougall, S. A., Vorhees, C. V. (2001, December). Long-term effects of neonatal methamphetamine on the striatal dopamine system in the adult rat. Poster session presented at the American College of Neuropsychopharmacology, HI

Williams, M. T.; Blankemeyer, T. L; Vorhees, C. V. (2001, April). Metyrapone inhibition of corticosterone production reverses d,l-fenfluramine-induced learning and memory deficits in the Cincinnati water maze. Poster session presented at the Tenth Annual meeting of the International Behavioral Neuroscience Society, Cancun, Mexico.

Johnson, J. R., Williams, M. T., & Becker, L. A. (2001, April). Increased dietary phytoestrogen intake during gestation and nursing alters anogenital distance, isolation-induced ultrasonic vocalizations, and adult testosterone titers of offspring. Poster session presented at the Tenth Annual meeting of the International Behavioral Neuroscience Society, Cancun, Mexico.

Williams, M.T., Klaber, F. L., Brown, C. A., & Vorhees, C. V. (2000, April). Performance in the Cincinnati water maze: relation to lighting conditions, strain differences, test order, and intertrial interval. Poster session presented at the Ninth annual meeting of the International Behavioral Neuroscience Society, Denver, CO.

Williams, M. T., Inman-Wood, S. L., Morford, L. L., McCrea, A. E., Ruttle, A. M., Moran, M. S., Rock, S. L., & Vorhees, C. V. (1999, June). A possible mechanism for Morris water maze deficits in adult rats which were administered methamphetamine during postnatal days 11-20. Paper presented at the Eighth annual meeting of the International Behavioral Neuroscience Society, Nancy, France.

Williams, M. T., Morford, L. L., McCrea, A. E., Inman-Wood, S. L., & Vorhees, C. V. (1999, June). Exposure of male rats to d,l-fenfluramine alters the hypothalamic-pituitary-adrenal axis and learning in the Cincinnati water maze. Poster session presented at the Eighth annual meeting of the International Behavioral Neuroscience Society, Nancy, France.

Hennessy, M. B., Williams, M. T., Mazzei, S. M., Douglas, C. W., & Davis, H. N. (1997, October). Behavior of isolated guinea pig pups after treatment with antisera to corticotropin-releasing factor. Poster session presented at the annual meeting of the International Society of Developmental Psychobiology, New Orleans.

Williams, M. T., Hennessy, M. B., Long, S., & Davis, H. N. (1996, May). The effects of stress during pregnancy on the response of the hypothalamic-pituitary-adrenal (HPA) axis in rats and their fetuses. Paper presented at the Fifth Annual International Behavioral Neuroscience Society Meeting, Cancun, Mexico.

McCrea, A. E., Williams, M. T., & Diana, J. N. (1996, May). Gestational stress (GS) applied during the light or the dark phase of the light/dark cycle has differential effects in rat offspring. Poster session presented at the Fifth Annual International Behavioral Neuroscience Society Meeting, Cancun, Mexico. Also, poster session presented at the Spring meeting of the Midwest Teratology Association, Perrysville, OH.

Hennessy, M. B., Davis, H. N., Williams, M. T., & Mellott, C. (1996, May). Plasma cortisol levels of dogs in an animal shelter. Paper presented at the Midwestern Psychological Association, Chicago, IL.

Williams, M. T., Hennessy, M. B., & Davis, H. N. (1995, May). Gestational stress alters preweanling offspring morphology and ultrasonic vocalization response to social isolation in rats. Poster session presented at the Annual Meeting of the International Behavioral Neuroscience Society, Santiago de Compostela, Spain.

Williams, M. T., Lyons, S., Hennessy, M. B., & Davis, H. N. (1994, May). Injection stress during pregnancy has lasting effects on offspring development and behavior in rats. Poster session presented at the Annual Meeting of the International Behavioral Neuroscience Society, Clearwater, FL.

Williams, M. T., Hennessy, M. B., & Davis, H. N. (1993, April). Administration of corticotropin releasing factor to pregnant rats has lasting effects on their preweanling offspring. Poster session presented at the Annual Meeting of the International Behavioral Neuroscience Society, Clearwater, FL.

Williams, M. T., Sims, M. L., Hennessy, M. B., & Davis, H. N. (1993, April). Postnatal administration of corticotropin releasing factor produces lasting effects on isolation vocalizations and basal corticosterone levels in preweanling rats. Paper presented at the Midwestern Psychological Association, Chicago, IL.

Williams, M. T., Becker, L. A., Nolan, D. J., & Hennessy, M. B. (1992, October). Corticotropin releasing factor (CRF): effects of peripheral administration on guinea pig pups during maternal separation. Poster session presented at the Annual Meeting of the International Society for Developmental Psychobiology, Newport Beach, CA.

Davis, H. N., Williams, M. T., Benghuzzi, H. A., England, B. G., & Bajpai, P. K. (1992, September) Sustained release of testosterone and dihydrotestosterone by ALCAP ceramic implants in rats. Paper presented at the Academy of Surgical Research, St. Charles, IL.

Hennessy, M. B., O'Neil, D. R., Becker, L. A., Jenkins, R., Williams, M. T., & Davis, H. N. (1991, November). Effects of centrally-injected CRH on the vocalizations of isolated guinea pig pups. Poster session presented at the Annual Meeting of the International Society for Developmental Psychobiology, New Orleans, LA.

THESIS AND DISSERTATION STUDENTS

Carrie A. Brown Committee member 2001-present. Molecular and Developmental Biology, University of Cincinnati.

PROFESSIONAL MEMBERSHIPS AND POSITIONS HELD

International Behavioral Neuroscience Society (IBNS)

1995-1996 Student representative for IBNS

1997-2000 Animal Use Committee for IBNS

1998-1999 co-chair Animal Use Committee for IBNS

1999-2000 chair Animal Use Committee for IBNS

Midwest Teratology Association

Neurobehavioral Teratology Society

Society for Neuroscience

OTHER PROFESSIONAL ACTIVITIES

Reviewer for Biological Psychology

Reviewer for Brain Research Bulletin

Reviewer for Environmental Health Perspectives

Reviewer for Neurotoxicology and Teratology

Reviewer for Pharmacology, Biochemistry and Behavior

TEACHING EXPERIENCE

Developmental Neuroscience, University of Cincinnati, Winter 2002. This is a team taught postgraduate seminar course for Pediatric Psychiatry Fellows. Responsible for the preparation and lecture for the section covering the development of neurotransmitter systems.

Teratology, University of Cincinnati, Winter 2000, Winter 2002. This is a team taught graduate course. Responsible for the preparation, lecture, and testing for the section covering drugs of abuse.

Introduction to Psychology (General Psychology II), Sinclair Community College, Winter 2001, Winter 2002. Complete responsibility for classroom preparation, lectures, testing, and student evaluations

Introduction to Psychology (General Psychology I), Sinclair Community College, Fall 2000, Spring 2001, Fall 2001, Winter 2002, Spring 2002. Complete responsibility for classroom preparation, lectures, testing, and student evaluations

Introduction to Psychology (The Science of Behavior II), Wright State University, Winter 1997 to Winter 1998, Fall 1998, Fall 1999, Winter 2000, Spring 2000. Complete responsibility for classroom preparation, lectures, testing, and student evaluations.

Introduction to Psychology (The Science of Behavior I), Wright State University, Winter 1999, Spring 1999. Complete responsibility for classroom preparation, lectures, testing, and student evaluations.

Hormones and Behavior, Wright State University, Spring 1998, Spring 1999, Spring 2000. Developed the course and had full responsibility for classroom preparation, lectures, testing, and student evaluations.

Biological Influences on Human Behavior, Antioch College, Spring 1998. Complete responsibility for classroom preparation, lectures, testing, and student evaluations.

Physiological Psychology, Wright State University, Fall 1997. Complete responsibility for classroom preparation, lectures, testing, and student evaluations.

Physiological Psychology Methods, Wright State University, Spring 1991 to Spring 1995 (Graduate Teaching Assistant). Responsibilities included: preparation of laboratory exercises, helping students during these exercises, demonstrating various techniques (i.e., stereotaxic procedures, histology)

Physiological Psychology Seminar, Wright State University, Winter 1994. Responsibilities included: preparation and presentation of advanced topics in physiological psychology concurrent with the formal class materials.

Laboratory for Introduction to Biology, Wright State University, Fall 1993 (Graduate Teaching Assistant). Responsibilities included: preparation of laboratory exercises and lectures, development of quizzes, and grading of students on their laboratory exercises.

Quantitative and Research Methods, Wright State University, Winter 1991 (Teaching Assistant). This was a graduate level course, and responsibilities included: tutoring students on the use of Statistical Analysis Systems (SAS) and grading SAS programs submitted by students.